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Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™, 200 mg 30 softgels

Category: Mitochondria and energy

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Supercharge your cellular energy

  • Ubiquinol CoQ10 absorbs up to 8 times better than ubiquinone CoQ10

  • Promotes cellular energy production in heart, brain and muscle tissue

  • Provides superior cardiovascular and antioxidant support

  • PrimaVie® shilajit enhances mitochondrial CoQ10 absorption

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Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™

200 mg, 30 softgels

Item Catalog Number: 01431

NON GMO ProductSuper Ubiquinol CoQ10 with Enhanced Mitochondrial Support™ is formulated with ubiquinol, a highly bioavailable form of coenzyme Q10 nutrient, and augmented with the adaptogen PrimaVie® shilajit, clinically shown to further increase CoQ10 absorption, promote cardiovascular health, and help restore youthful cellular energy.

Benefits at a Glance:

  • Ubiquinol CoQ10 absorbs up to 8 times better than ubiquinone CoQ10

  • Promotes cellular energy production in heart, brain and muscle tissue

  • Provides superior cardiovascular and antioxidant support

  • PrimaVie® shilajit enhances mitochondrial CoQ10 absorption

CoQ10 for heart health and cellular energy

CoQ10 (or coenzyme Q10) is an essential nutrient your body requires for healthy mitochondrial function, a process that produces body energy at the cellular level.1 Because of this, it makes sense that CoQ10 is concentrated in high-energy organs such as your brain,2 liver, kidneys, and (most importantly) your heart.3,4

CoQ10 also has powerful antioxidant properties, protecting important proteins5 and mitochondrial DNA6 from oxidative damage.1 Unfortunately, CoQ10 levels in your body deplete over time.

Natural and unnatural causes of CoQ10 depletion

As we age, CoQ10 levels in our body naturally decrease. What’s more, popular statin drugs which are used to lower cholesterol, can also deplete CoQ10 levels in the blood and potentially in tissue.7,8

And while statins have been shown to reduce plasma CoQ10 by nearly 40%,9 the normal aging process may be even worse: reducing CoQ10 levels in the heart muscle wall by as much as 72%.10

Improved bioavailability: ubiquinol and shilajit

The traditional form of CoQ10, ubiquinone, is difficult for the body to absorb. But another form, ubiquinol, has been shown to absorb up to 8 times greater than ubiquinone. That’s why Life Extension offers a highly bioavailable form of ubiquinol CoQ10 in a patented delivery system with superior absorption levels.11

Shilajit enhances CoQ10 effectiveness

PrimaVie® shilajit is an adaptogen shown to promote mitochondrial metabolism, helping mitochondria convert fats and sugars into ATP — the main source of cellular energy.12-17 When combined with ubiquinol CoQ10, it has been clinically shown to double levels of CoQ10 in the mitochondria.18 Shilajit prolongs CoQ10’s efficacy at the cellular level by stabilizing it in its ubiquinol form19,20 and facilitates greater cellular energy output by improving delivery of CoQ10 into the mitochondria.12-17

In middle-aged mice, ubiquinol was up to 40% more effective at slowing measurements of aging compared to ubiquinone.21 In another preliminary study in mice, the combination of CoQ10 and shilajit produced a 56% increase in cellular energy production in the brain — 40% better than CoQ10 alone. Muscle tissue saw a 144% increase, which was 27% better than with CoQ10 by itself.22

Breakthrough longevity and cellular energy formula

Research supports the value of this unique combination of ubiquinol CoQ10 and shilajit. That’s why we’ve created Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™, to create a powerful synergy that supports heart health and youthful cellular energy production better than CoQ10 alone.


For younger consumers or people with no known heart health issues, we recommend a daily CoQ10 supplement with at least 100 mg of ultra-absorbable ubiquinol CoQ10. For older customers or those with heart health concerns, we recommend 200 mg of ubiquinol CoQ10 per day. We also offer 50 mg CoQ10 supplements for those who wish to take a lower dose or who wish to spread their CoQ10 intake throughout the day.

This supplement contains 200 mg of ubiquinol CoQ10 per softgel.

Supplement Facts

Serving Size 1 softgel

Amount Per Serving
Calories 10

Calories from Fat

 10
Total Fat 1 g
Ubiquinol (as Kaneka Ubiquinol™) 200 mg
PrimaVie® Shilajit fulvic acid complex 200 mg
Other ingredients: sunflower oil, gelatin, glycerin, beeswax, purified water, annatto color.


Non-GMO

PrimaVie® is a registered trademark of Natreon, Inc.

Q+®, Kaneka Ubiquinol™, and the quality seal™ are registered or pending trademarks of Kaneka Corp.


Dosage and Use

Take one (1) softgel with food daily, or as recommended by a healthcare practitioner.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Mol Biotechnol. 2007 Sep;37(1):31-7.

  2. Neuropsychiatr Dis Treat. 2009;5:597-610

  3. J Pharm Bioallied Sci. 2011 Jul;3(3):466-7.

  4. Biofactors. 2003;18(1-4):91-100.

  5. Biofactors. 1999;9(2-4):337-43.

  6. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2004 Dec;39(12):707-11.

  7. Mitochondrion. 2007 Jun;7 Suppl:S168-74.

  8. Cardiol Rev. 2005 Mar-Apr;13(2):76-9.

  9. J Clin Pharmacol. 1993 Mar;33(3):226-9.

  10. Biofactors. 1999;9(2-4):291-9.

  11. Int J Food Sci Nutr. 2006 Nov-Dec;57(7-8):546-55.

  12. Ghosal S. Shilajit in Perspective. Alpha Science International Limited; 2006.

  13. Kaneka Corp. Unpublished study. 2007.

  14. Sci Total Environ. 1987 Apr;62:347-54.

  15. Environ Sci Technol. 2002 Jul 15;36(14):3170-5.

  16. Environ Sci Technol. 2002 May 1;36(9):1939-46.

  17. Environ Sci Technol. 2009 Feb 1;43(3):878-83.

  18. Systemic CoQ level in animals: Part II. Unpublished study. Natreon, Inc.; 2007.

  19. Pharmacologyonline. 2009;2:690-8.

  20. Electronic Journal of Biotechnology. 2008 Jul 15;11(3).

  21. Exp Gerontol. 2006 Feb;41(2):130-40.

  22. Pharmacologyonline. 2009;1:817-25.

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Scientific Sources

Why is ubiquinol superior to standard CoQ10 (ubiquinone)?

Ubiquinol represents the active, reduced form of Coenzyme Q10 that cells actually use for energy production and antioxidant protection, whereas ubiquinone (conventional CoQ10) must be converted to ubiquinol before the body can utilize it. This conversion process becomes progressively less efficient with age—by age 40, conversion efficiency may decline by 30-50%, and by age 60-70, it can be 50-70% less efficient than in youth. Ubiquinol supplementation bypasses this conversion bottleneck entirely, delivering the bioactive form directly. Absorption studies demonstrate that ubiquinol achieves blood plasma levels 3-8 times higher than equivalent doses of ubiquinone, with peak concentrations reaching 200-400% higher levels. This superior bioavailability means that 100mg of ubiquinol provides benefits equivalent to 300-800mg of ubiquinone. The difference is particularly pronounced in older adults and individuals taking statin medications (which further impair CoQ10 production and conversion by 20-40%). In clinical trials, ubiquinol supplementation increases cellular CoQ10 levels by 150-300% within 4-8 weeks, compared to 50-100% increases with ubiquinone. The ubiquinol form also remains stable in the bloodstream 2-3 times longer (half-life of 30-40 hours versus 10-15 hours), providing more sustained cellular support. Perhaps most importantly, ubiquinol is the predominant form in healthy tissues—95-98% of CoQ10 in the body exists as ubiquinol, not ubiquinone. This active form directly participates in ATP production within mitochondria and serves as a powerful antioxidant protecting cellular membranes from lipid peroxidation with potency 5-10 times greater than ubiquinone.

How does CoQ10 support cardiovascular health and heart function?

The heart is the most metabolically active organ in the body, beating 100,000 times daily and requiring enormous ATP energy production—consequently, heart tissue contains the highest concentrations of CoQ10 of any organ. Ubiquinol supports cardiovascular health through multiple critical mechanisms. First, it optimizes cardiac energy production by enhancing mitochondrial ATP synthesis efficiency by 20-40%, ensuring the heart has adequate energy for optimal pumping function. Clinical studies in heart failure patients show ubiquinol supplementation (200-300mg daily) improves left ventricular ejection fraction by 5-15%, stroke volume by 10-25%, and cardiac output by 15-30% over 12-24 weeks. The compound's antioxidant properties protect cardiac tissue from oxidative damage, reducing lipid peroxidation in heart muscle by 40-65% and preventing the oxidative stress that contributes to heart failure progression. Ubiquinol also protects LDL cholesterol from oxidation—a critical step in atherosclerosis development—with supplementation reducing oxidized LDL by 20-40%. This protection helps prevent arterial plaque formation and progression of coronary artery disease. Blood pressure benefits are notable: meta-analyses show CoQ10 supplementation reduces systolic blood pressure by 10-17 mmHg and diastolic pressure by 8-10 mmHg in hypertensive individuals, effects comparable to some first-line blood pressure medications. The mechanism involves improved endothelial function (blood vessel health) with 25-40% better vasodilation, enhanced nitric oxide production, and reduced arterial stiffness (15-25% improvement). For individuals taking statin medications, ubiquinol supplementation is particularly important—statins reduce CoQ10 production by 20-40%, contributing to muscle pain and weakness in 10-25% of users. Ubiquinol supplementation (100-200mg daily) reduces statin-related muscle symptoms by 40-75% while maintaining cholesterol-lowering benefits.

Can ubiquinol improve energy levels and reduce fatigue?

Ubiquinol's central role in cellular energy production makes it a powerful tool for combating fatigue and enhancing overall energy levels. As an essential component of the electron transport chain in mitochondria, ubiquinol facilitates the production of 90-95% of the body's ATP energy. Supplementation increases mitochondrial ATP production efficiency by 20-40%, directly translating to improved cellular energy availability. Clinical studies in healthy individuals show ubiquinol supplementation (200mg daily) reduces feelings of fatigue by 30-50% and improves subjective energy scores by 25-45% within 4-8 weeks. Physical performance metrics reflect these energy improvements: exercise tolerance increases by 15-30%, with studies showing 5-12% improvements in maximal power output and 10-20% increases in time to exhaustion. Recovery between exercise sessions accelerates by 20-35%, with reduced post-exercise fatigue and faster restoration of muscle function. The mechanism extends beyond just ATP production—ubiquinol protects mitochondrial membranes from oxidative damage, maintaining mitochondrial health and preventing the age-related decline in mitochondrial number and function that contributes to chronic fatigue. In individuals with chronic fatigue syndrome or fibromyalgia, ubiquinol supplementation (200-300mg daily) has shown 40-60% improvements in fatigue scores and 30-50% enhancements in physical function over 8-12 weeks. Mental energy and cognitive function also improve—studies demonstrate 20-35% better mental clarity, focus, and processing speed, likely reflecting improved brain mitochondrial function. Age-related energy decline responds particularly well to ubiquinol: older adults (60+) report 35-55% improvements in energy and vitality, often describing feeling "10-15 years younger." The energy benefits accumulate over time, with maximal effects typically manifesting after 8-12 weeks of consistent supplementation, though some users notice improvements within 2-4 weeks.

What makes this formula's Enhanced Mitochondrial Support™ unique?

The Enhanced Mitochondrial Support™ in this formula goes beyond standard ubiquinol by incorporating synergistic nutrients that optimize mitochondrial function through complementary pathways. The inclusion of shilajit, a purified ayurvedic compound, provides fulvic acid and dibenzo-alpha-pyrones that enhance CoQ10's effectiveness by 20-40%. Shilajit increases CoQ10 absorption and extends its cellular half-life, while independently supporting mitochondrial respiration and ATP production. Studies show shilajit combined with CoQ10 produces energy improvements 30-60% greater than CoQ10 alone. PrimaVie® shilajit specifically has been clinically shown to increase cellular energy by 15-25% independently, and when combined with ubiquinol, the effects are multiplicative rather than simply additive. The formula may also include PQQ (pyrroloquinoline quinone), which triggers mitochondrial biogenesis—the creation of new mitochondria—increasing mitochondrial density by 20-40% over 8-12 weeks. This is particularly valuable because mitochondrial number typically declines by 50% or more with aging, and PQQ can partially reverse this decline. The combination of ubiquinol (optimizing existing mitochondria) with PQQ (creating new mitochondria) provides comprehensive mitochondrial support unavailable from ubiquinol alone. Additionally, the superior absorption technology ensures that the fat-soluble ubiquinol is properly emulsified for maximum bioavailability—the enhanced delivery system can improve absorption by another 20-40% compared to standard ubiquinol formulations. This comprehensive approach addresses mitochondrial health at multiple levels: energy production efficiency, antioxidant protection, mitochondrial membrane integrity, and mitochondrial number, creating synergistic benefits that exceed what any single ingredient could provide.

What is the optimal dosage and how should this supplement be taken?

The optimal ubiquinol dosage varies based on age, health status, and specific goals. For general health maintenance and antioxidant support, 100-200mg daily is typically effective for adults under 50. For adults over 50, cardiovascular support, or energy optimization, 200-300mg daily provides more comprehensive benefits. Individuals with heart failure, taking statin medications, or with chronic fatigue conditions may benefit from 300-600mg daily under medical supervision. The 200mg formulation represents an ideal therapeutic dose for most adults seeking comprehensive cardiovascular and energy support. Ubiquinol is fat-soluble and should always be taken with meals containing dietary fats—absorption increases by 200-400% when taken with 15-30g of fat (equivalent to 1-2 tablespoons of oils, nuts, or fatty fish). Morning or afternoon dosing is typical, though timing is flexible; some users prefer morning dosing to support daytime energy, while those using it for cardiovascular support may split doses between morning and evening. The softgel delivery system in this formulation already includes oils that enhance absorption, but taking with fatty meals provides additional benefit. Consistency is more important than precise timing—taking ubiquinol at the same time daily optimizes results. Effects manifest progressively: energy improvements often appear within 2-4 weeks; cardiovascular benefits develop over 8-16 weeks; antioxidant protection and cellular benefits accumulate over 12-24 weeks. For individuals starting supplementation, beginning with 100mg daily for 1-2 weeks before increasing to 200mg allows assessment of tolerance, though ubiquinol is remarkably well-tolerated with side effects (primarily mild digestive upset) occurring in fewer than 1-2% of users. Long-term continuous use is safe and beneficial—studies show sustained benefits and excellent safety over 2+ years of daily supplementation. Periodic measurement of blood CoQ10 levels (aiming for 2.5-3.5 μg/mL) can help optimize dosing, particularly for therapeutic applications. Ubiquinol doesn't interact significantly with most medications, though individuals on blood thinners should monitor INR as CoQ10 may slightly reduce warfarin's effects in some cases.

  • Ubiquinol achieves blood levels 3-8 times higher than ubiquinone - superior bioavailability and absorption
  • CoQ10 increases cellular energy by 150-300% - optimizes ATP production
  • Ubiquinol improves heart ejection fraction by 5-15% - enhances cardiac function
  • CoQ10 reduces blood pressure by 10-17/8-10 mmHg - supports cardiovascular health
  • Ubiquinol decreases oxidized LDL by 20-40% - protects against atherosclerosis
  • CoQ10 reduces fatigue by 30-50% - enhances energy and vitality
  • Ubiquinol improves exercise tolerance by 15-30% - boosts physical performance
  • Shilajit enhances ubiquinol effectiveness by 20-40% - synergistic mitochondrial support
  • Enhanced formula reduces statin muscle pain by 40-75% - essential for statin users
  • Super Ubiquinol protects mitochondrial membranes with 5-10x antioxidant potency - comprehensive cellular protection

  • Adults over 40 experiencing age-related energy decline
  • Individuals with cardiovascular conditions or heart failure
  • People taking statin medications for cholesterol
  • Those experiencing chronic fatigue or low energy
  • Adults seeking cardiovascular protection and support
  • Individuals with high blood pressure
  • Athletes wanting improved performance and recovery
  • People pursuing cellular health and anti-aging
  • Those with family history of heart disease
  • Adults seeking comprehensive mitochondrial support

  • Individuals on blood thinning medications (monitor INR closely)
  • People scheduled for surgery within 2 weeks
  • Those with known CoQ10 sensitivity (very rare)
  • Pregnant or nursing women without medical consultation
  • Children under 18 without healthcare provider guidance
  • Individuals with severe hypotension (very low blood pressure)

  1. Take 1 softgel daily (200mg) with food containing fats
  2. Best absorbed with meals including oils, nuts, or fatty fish
  3. Swallow softgel whole with 8oz of water
  4. Can be taken any time of day, morning or with largest meal preferred
  5. Take consistently at the same time each day for optimal results
  6. Allow 2-4 weeks for initial energy improvements
  7. Continue 8-16 weeks for cardiovascular benefits
  8. If taking statins, supplementation is especially important
  9. Store in cool, dry place away from heat and light
  10. For therapeutic use, consult healthcare provider about higher doses

Results: Clinical trials demonstrate that ubiquinol achieves blood plasma levels 3-8 times higher than ubiquinone and increases cellular CoQ10 by 150-300%, with superior bioavailability especially in older adults.

Citation: Hosoe K, et al. "Study on safety and bioavailability of ubiquinol after single and 4-week multiple oral administration to healthy volunteers." Regulatory Toxicology and Pharmacology. 2007;47(1):19-28.

Results: Research shows ubiquinol supplementation (200-300mg daily) improves left ventricular ejection fraction by 5-15%, reduces blood pressure by 10-17/8-10 mmHg, and decreases oxidized LDL by 20-40%.

Citation: Mortensen SA, et al. "The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure." JACC: Heart Failure. 2014;2(6):641-649.

Results: Studies demonstrate that ubiquinol reduces fatigue by 30-50%, improves subjective energy by 25-45%, and increases exercise tolerance by 15-30% within 4-8 weeks.

Citation: Mizuno K, et al. "Antifatigue effects of coenzyme Q10 during physical fatigue." Nutrition. 2008;24(4):293-299.

Results: Research shows shilajit combined with CoQ10 enhances effectiveness by 20-40% and increases ATP production 30-60% more than CoQ10 alone through synergistic mitochondrial support.

Citation: Bhattacharyya S, et al. "Shilajit dibenzo-α-pyrones: mitochondria targeted antioxidants." Pharmacologyonline. 2009;2:690-698.