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Super R-Lipoic Acid EU

Category: Mitochondria and energy

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Protects against oxidative stress

  • Potent antioxidant that achieves healthy plasma levels already within normal range

  • Helps protect against oxidative stress

  • Supports healthy mitochondrial function

  • Preserves youthful cellular energy

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Super R-Lipoic Acid

240 mg, 60 vegetarian capsules

Item Catalog Number: 01208EU

NON GMO ProductPublished studies have shown the critical importance of lipoic acid in preserving youthful cellular energy by supporting healthy mitochondrial function. Unlike other forms of lipoic acid, Super R-Lipoic Acid is more bioavailable, stable, and potent, achieving 10–30 times higher peak blood levels than pure R-lipoic acid. This unique sodium-R-lipoate can help you reach peak plasma concentrations within just 10–20 minutes of supplementation. Super R-Lipoic Acid provides more of the active "R" form than conventional alpha-lipoic acid products. Try this next-generation lipoic acid today!

Benefits at a Glance

  • Potent antioxidant that achieves healthy plasma levels already within normal range

  • Helps protect against oxidative stress

  • Supports healthy mitochondrial function

  • Preserves youthful cellular energy

Potent Antioxidant that Achieves Peak Plasma Levels

Super R-Lipoic Acid is a potent antioxidant that supports healthy mitochondria, preserves youthful cellular energy, and helps protect against oxidative stress.. Unlike other forms of lipoic acid, Super R-Lipoic Acid is more bioavailable, stable, and potent, achieving 10–30 times higher peak blood levels than pure R-lipoic acid.

This unique sodium-R-lipoate can help you reach peak plasma concentrations within just 10–20 minutes of supplementation. Super R-Lipoic Acid provides more of the active "R" form of lipoic acid than any other supplement.


“R” Lipoic Acid is Biologically Active

Alpha-lipoic acid, the universal antioxidant, consists of two different forms (isomers) — R and S — that have vastly different properties. The “R” form is the biologically active component (native to the body) that is responsible for lipoic acid’s phenomenal antioxidant effect. The “S” form is produced from chemical manufacture and is not very biologically active. Alpha-lipoic acid supplements typically consist of the "R" and "S" form in a 50/50 ratio. That means a 100 mg alpha-lipoic acid supplement is providing 50 mg of the biologically active "R" form.

The human body normally produces and uses the "R" form of lipoic acid. This active form, R-lipoic acid, significantly supports healthy inflammatory response, is a potent free radical scavenger, and has been shown to be more potent than the combined "R" and "S" forms that ordinarily comprise alpha-lipoic acid supplements.1-11


Unique Sodium-R-Lipoate is the “Next-Generation” Antioxidant

Through dedicated research and development, a newer form of R-lipoic acid has been discovered and is being seen as the "next-generation" antioxidant powerhouse. R-lipoic acid already has demonstrated superior bioavailability, stability, and potency for a variety of health benefits.

But a breakthrough process converts the biologically active "R" form of lipoic acid to sodium-R-lipoate, which, in a recent human study achieved higher peak blood levels than pure R-lipoic acid.12

Not only does this newer lipoic acid formulation reach higher peak blood levels,13 it also achieves them sooner, ensuring rapid uptake from the plasma into the tissues.12 A study showed that oral ingestion of Super R-Lipoic Acid, after converting to sodium-R-lipoate, reached peak plasma concentrations within just 10–20 minutes of supplementation.13


Enhanced Antioxidant Activity through Stability and High Potency

Unlike other forms of lipoic acid, Super R-Lipoic Acid is more stable in the body. The increased stability of this enhanced formulation is the reason for its greater absorption and bioavailability compared with R-lipoic acid.

The superior antioxidant effects of R-lipoic acid are already well-known for supporting healthy mitochondrial function. Now, Super R-Lipoic Acid provides even more potent benefits for preserving youthful cellular energy levels.

Supplement Facts

Serving Size 1 vegetarian capsule

Amount Per Day (1 capsule)
R-Lipoic acid from Bio-Enhanced™ Stabilized Na-RALA sodium R-lipoate 240 mg
Ingredients: sodium R-lipoate, anti-caking agents (magnesium salts of fatty acids, fatty acids, calcium silicate), purified water, capsule (hydroxypropyl methyl cellulose)


Non-GMO


Dosage and Use

Take one (1) capsule daily, preferably on an empty stomach.


Caution

If you are taking glucose lowering medication, consult your healthcare provider before taking this product.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.


  1. Pharmacol Res. 2011 Jan;63(1):23-9.

  2. Ann N Y Acad Sci. 2010 Aug;1203:151-9.

  3. Wien Klin Wochenschr. 2006 Mar;118(3-4):100-7.

  4. Free Radic Res. 2004 Oct;38(10):1083-92.

  5. Nutrition. 2001 Oct;17(10):888-95.

  6. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1463-70.

  7. Arch Pharm (Weinheim). 2010 Mar;343(3):133-42.

  8. Metabolism. 2008 Oct;57(10):1465-72.

  9. Brain Res. 2000 Feb 14;855(2):292-7.

  10. Ann N Y Acad Sci. 2002 Apr;959:491-507.

  11. Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R587-97.

  12. Carlson DA, et al. Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects. Taylor & Francis Publishers; 2008:235-70.

  13. Altern Med Rev. 2007 Dec;12(4):343-51.

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Scientific Sources

What is R-Lipoic Acid and how does it differ from regular alpha-lipoic acid?

R-Lipoic Acid is the naturally occurring, biologically active form of alpha-lipoic acid found in the body and food sources. Standard alpha-lipoic acid supplements contain a 50/50 mixture of R and S forms, but only the R form is produced naturally by human cells and utilized by mitochondria. R-Lipoic Acid is significantly more bioavailable and potent than the synthetic S form, with studies showing it achieves 10-30 times higher blood levels. This superior absorption means R-Lipoic Acid delivers more powerful antioxidant protection and metabolic support at lower doses than standard lipoic acid supplements.

How does R-Lipoic Acid support cellular energy and mitochondrial function?

R-Lipoic Acid is a critical cofactor for mitochondrial enzymes involved in energy production from glucose and fats. It works within mitochondria to support efficient conversion of nutrients into ATP, the cellular energy currency. As we age, mitochondrial function declines and R-lipoic acid levels decrease, contributing to reduced energy and increased oxidative stress. Supplementation helps restore optimal mitochondrial function, supporting healthy energy metabolism throughout the body. R-Lipoic Acid also chelates metals and recycles other antioxidants like vitamins C and E, glutathione, and CoQ10, creating a comprehensive antioxidant network that protects mitochondria from damage.

What are the primary health benefits of R-Lipoic Acid supplementation?

R-Lipoic Acid provides comprehensive metabolic and antioxidant support. It helps maintain healthy blood sugar metabolism by enhancing insulin sensitivity and glucose uptake into cells. As a universal antioxidant working in both water and fat-soluble environments, it protects cells throughout the body from oxidative damage. R-Lipoic Acid supports cardiovascular health, cognitive function, and healthy aging by protecting against glycation and oxidative stress. It supports nerve health and comfortable nerve function, particularly beneficial for peripheral nerves. The compound also supports liver detoxification, healthy inflammatory responses, and helps maintain healthy weight management through improved metabolic efficiency.

Why is R-Lipoic Acid particularly important for blood sugar support?

R-Lipoic Acid enhances insulin function and glucose metabolism through multiple mechanisms. It activates AMPK, an enzyme that signals cells to increase glucose uptake and utilization. Studies show it improves insulin sensitivity, helping the body use insulin more efficiently to maintain healthy blood sugar levels already within normal range. R-Lipoic Acid also protects against oxidative stress caused by elevated blood sugar, preventing glycation damage to proteins and tissues. Clinical research demonstrates significant improvements in glucose metabolism markers with R-lipoic acid supplementation, making it valuable for metabolic health support and maintaining healthy hemoglobin A1c levels.

How should I take Super R-Lipoic Acid for maximum benefits?

For optimal absorption, take R-Lipoic Acid on an empty stomach at least 30 minutes before meals, as food can significantly reduce absorption. However, if you experience stomach upset, taking with a small amount of food is acceptable. The short half-life of R-lipoic acid means splitting doses throughout the day maintains more stable blood levels, though once-daily dosing still provides benefits. Start with recommended doses and increase gradually if needed. Take consistently at the same times daily for best metabolic support. R-Lipoic Acid works synergistically with other mitochondrial nutrients like CoQ10, acetyl-L-carnitine, and B vitamins for comprehensive cellular energy support.

  • Provides R-form lipoic acid the only naturally occurring biologically active form - superior bioavailability
  • R-Lipoic Acid supports healthy blood sugar metabolism and insulin sensitivity naturally - glucose support
  • Acts as universal antioxidant with lipoic acid protecting water and fat-soluble environments - comprehensive protection
  • R-Lipoic Acid supports mitochondrial function and healthy cellular energy production - energy support
  • Helps recycle and regenerate other antioxidants with R-lipoic acid including vitamins C E - antioxidant network
  • R-Lipoic Acid supports comfortable nerve function and peripheral nerve health naturally - nerve support
  • Promotes healthy inflammatory response with R-lipoic acid and protects against oxidative stress - inflammation balance
  • R-Lipoic Acid supports cardiovascular health and healthy blood vessel function - heart health
  • Helps protect against glycation with R-lipoic acid and advanced glycation end products - anti-glycation
  • R-Lipoic Acid supports liver detoxification and healthy weight management efforts - metabolic support

  • Individuals seeking to support healthy blood sugar metabolism and insulin sensitivity naturally
  • People wanting comprehensive antioxidant protection and mitochondrial energy support throughout body
  • Those interested in supporting comfortable nerve function and peripheral nerve health
  • Adults concerned about healthy aging and protection against oxidative cellular damage
  • Individuals seeking superior bioavailable R-form lipoic acid for maximum effectiveness

  • People with diabetes taking medications should monitor blood sugar closely with doctor
  • Those with thyroid disorders should consult healthcare provider before supplementation
  • Individuals undergoing chemotherapy should verify compatibility with oncologist first
  • Pregnant or nursing women should seek medical advice before using R-lipoic acid
  • People taking high doses should monitor for potential biotininterference effects

  1. Take on empty stomach at least 30 minutes before meals for optimal absorption
  2. If stomach upset occurs take with small amount of food to minimize discomfort
  3. Consider splitting daily dose throughout day to maintain more stable blood levels
  4. Take consistently at same times each day for best metabolic support results
  5. Combine with biotin supplementation if taking high doses long-term as precaution
  6. Works synergistically with CoQ10 carnitine and B vitamins for mitochondrial support
  7. Monitor blood sugar levels if diabetic and work with doctor to adjust medications
  8. Store in cool dry place away from light and moisture to preserve potency

Results: Clinical studies demonstrate R-Lipoic Acid is significantly more bioavailable than racemic alpha-lipoic acid, achieving plasma concentrations 10-30 times higher than S-lipoic acid, providing superior antioxidant protection and metabolic benefits at equivalent or lower doses.

Citation: Carlson DA, et al. Altern Med Rev. 2007 Dec;12(4):343-51.

Results: Research shows R-lipoic acid supplementation improves insulin sensitivity and glucose disposal by 20-30% in clinical trials, supporting healthy blood sugar metabolism through enhanced GLUT4 transporter activation and increased cellular glucose uptake.

Citation: Kamenova P. Arzneimittelforschung. 2006;56(10):635-8.

Results: Studies indicate R-lipoic acid provides neuroprotection and supports comfortable nerve function, with clinical trials showing improvements in nerve conduction velocity and reductions in discomfort associated with peripheral nerve concerns after 3-5 weeks supplementation.

Citation: Ziegler D, et al. Diabetes Care. 2006 Nov;29(11):2365-70.

Results: Clinical research demonstrates R-lipoic acid acts as universal antioxidant scavenging multiple reactive oxygen species while recycling vitamins C and E and regenerating glutathione, creating comprehensive cellular antioxidant defense network protecting against oxidative damage.

Citation: Packer L, et al. Free Radic Biol Med. 1997;22(1-2):359-78.