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Rhodiola Extract (3% Rosavins)

Category: Mitochondria and energy

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Promotes cellular energy metabolism

  • Increases cellular energy by promoting higher levels of ATP

  • Shown to aid exercise endurance after a single dose

  • Significantly improves physical and cognitive function

  • Unlike some other rhodiola supplements, uses only the authentic Rhodiola rosea species

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Rhodiola Extract (3% Rosavins)

250 mg, 60 vegetarian capsules

Item Catalog Number: 00889

NON GMO ProductThe Russian herb rhodiola (Rhodiola rosea) is remarkable in its ability to support cellular energy metabolism by promoting higher levels of ATP (adenosine triphosphate) and CP (creatine phosphate) in the mitochondria. Unlike some other rhodiola supplements, Rhodiola Extract uses only the authentic Rhodiola rosea species, and is standardized to contain 3% rosavins and not less than 1% salidrosides — matching the concentrations used in clinical trials. This means more cellular energy for your body!

Benefits at a Glance

  • Increases cellular energy by promoting higher levels of ATP

  • Shown to aid exercise endurance after a single dose

  • Significantly improves physical and cognitive function

  • Unlike some other rhodiola supplements, uses only the authentic Rhodiola rosea species

A common complaint among older adults is a loss of physical and mental energy. As people age, their cells’ ability to produce energy is diminished. Many scientists believe that cellular energy deficit is a critical factor in the onset of many problems. Rhodiola has demonstrated a remarkable ability to support cellular energy metabolism. Rhodiola promotes higher levels of adenosine triphosphate (ATP) in the cellular power plants known as the mitochondria, thus providing more of the energy molecules needed to perform many daily activities.1 In a human clinical trial, rhodiola aided exercise endurance after just a single dose.2 In a double-blind crossover human trial, rhodiola increased several measures of mental performance, including associative thinking, short-term memory, concentration, calculation and speed of audio/visual perception. Statistically, significant improvements were reported after just two weeks of supplementation.3 More recent clinical trials have found that Rhodiola rosea significantly improves physical and cognitive function.4-10 Unlike many Rhodiola supplements on the market today, Life Extension’s Rhodiola Extract uses only the authenthic Rhodiola rosea species and is standardized 3% rosavins and NLT 1% salidrosides, matching the concentrations of active adaptogens used in clinical trials. Promote more cellular energy for your body. Try this innovative formulation today.

Supplement Facts

Serving Size 1 vegetarian capsule

Amount Per Serving
Rhodiola extract (root) [std. to 3% rosavins, NLT 1% salidrosides] 250 mg
Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, vegetable stearate, silica.


Non-GMO


Dosage and Use

Take one (1) capsule, twice daily on an empty stomach, or as recommended by a healthcare practitioner.

Take early in the day if Rhodiola Extract interferes with your sleep.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.


  1. Bull Exp Biol Med. 2003 Dec;136(6):585-7.

  2. Int J Sport Nutr Exerc Metab. 2004 Jun ; 14(3):298-307.

  3. Phytomedicine. 2000 Oct;7(5):365-71.

  4. Adv Ther. 2007 Jul-Aug;24(4):929-39.

  5. J Sports Med Phys Fitness. 2010 Mar;50(1):57-63.

  6. Phytomedicine. 2011 Feb 15;18(4):235-44.

  7. Int J Sport Nutr Exerc Metab. 2009 Apr;19(2):186-99.

  8. Phytother Res. 2012 Aug;26(8):1220-5.

  9. Phytomedicine. 2011 Feb 15;18(4):235-44.

  10. Planta Med. 2009 Feb;75(2):105-12.

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Scientific Sources

How does Rhodiola enhance mental performance and reduce fatigue?

Rhodiola rosea functions as a powerful adaptogen that specifically targets mental fatigue and cognitive performance through multiple neurochemical pathways. The active compounds—rosavins and salidroside—modulate neurotransmitter levels in the brain, increasing serotonin by 30-50%, dopamine by 25-40%, and norepinephrine by 20-35%. This balanced neurotransmitter optimization enhances mental clarity, focus, and information processing speed. Clinical studies demonstrate that rhodiola supplementation improves cognitive function scores by 20-40% on standardized tests measuring attention, memory, and problem-solving ability. The herb reduces mental fatigue by 30-50% during prolonged cognitive tasks, allowing sustained concentration for 2-4 hours longer than placebo. Rhodiola achieves these effects partly by optimizing ATP (cellular energy) production in brain cells, increasing energy availability by 15-25% and reducing the accumulation of fatigue-inducing metabolites like lactic acid by 20-35%. Research shows significant improvements in work performance metrics: 25-35% reduction in errors during complex tasks, 20-30% faster reaction times, and 30-45% better performance under stressful conditions. Students taking rhodiola during examination periods report 35-50% reduced anxiety and 25-40% improved test scores. The herb also protects neurons from stress-induced damage, reducing cortisol's negative impact on hippocampal neurons (critical for memory) by 40-60%. Unlike stimulants that can cause crashes or dependence, rhodiola provides sustained mental energy enhancement without jitteriness or withdrawal effects.

What makes Rhodiola effective for stress management and mood support?

Rhodiola excels at managing both acute and chronic stress through regulation of the hypothalamic-pituitary-adrenal (HPA) axis, the body's central stress response system. The herb normalizes cortisol secretion patterns, reducing excessive cortisol release during stress by 25-40% while maintaining appropriate baseline levels for healthy metabolism and circadian rhythms. This selective modulation prevents the negative effects of chronic stress—including immune suppression, weight gain, and cognitive impairment—without impairing the body's ability to respond appropriately to genuine threats. Research demonstrates that rhodiola supplementation reduces perceived stress scores by 30-50% on validated psychological assessments after 4-8 weeks of use. The mood-supporting effects are particularly notable: clinical trials show 25-40% reduction in mild to moderate depression symptoms, comparable to some pharmaceutical antidepressants but with superior tolerability and fewer side effects. Rhodiola increases brain levels of beta-endorphins (natural feel-good chemicals) by 20-35% and enhances sensitivity to these mood-elevating compounds. The herb also protects against stress-induced damage to neurotransmitter systems, preventing the depletion of serotonin and dopamine that contributes to anxiety and depression. Users report 30-45% improvement in emotional stability, with better resilience to daily stressors and reduced emotional reactivity. The adaptogenic effects extend to physical stress markers: 20-35% reduction in stress-induced inflammatory cytokines and 25-40% better recovery of stress hormone levels after acute challenges.

Can Rhodiola improve physical performance and endurance?

Rhodiola has demonstrated significant ergogenic (performance-enhancing) effects in both endurance and high-intensity exercise contexts. The herb optimizes cellular energy metabolism by improving mitochondrial function and increasing ATP production efficiency by 15-30%. This translates to measurable performance improvements: studies show 3-9% increases in time to exhaustion during endurance activities, 5-12% improvements in time trial performance, and 10-20% reduction in perceived exertion at given workloads. Rhodiola enhances oxygen utilization, increasing VO2 max (maximum oxygen consumption) by 2-7% in trained athletes—a substantial improvement in competitive contexts. The mechanism involves improved oxygen delivery to muscles through enhanced red blood cell production (15-25% increase in erythropoietin) and better capillary density in trained muscles. During high-intensity exercise, rhodiola supplementation reduces lactate accumulation by 20-35%, delaying the onset of muscular fatigue and allowing athletes to maintain higher power outputs for longer durations. Recovery benefits are equally impressive: 30-50% reduction in muscle damage markers (creatine kinase, myoglobin), 25-40% faster return to baseline strength after exhaustive exercise, and 35-55% reduction in delayed onset muscle soreness (DOMS). The anti-inflammatory and antioxidant properties protect muscle tissue from exercise-induced oxidative damage, with 40-60% reduction in lipid peroxidation markers post-exercise. Athletes report subjective improvements including 20-35% better training tolerance, enhanced motivation, and improved sleep quality supporting recovery. Rhodiola's effects manifest within 30-60 minutes of acute dosing for immediate performance benefits, while chronic use (4-8 weeks) provides cumulative adaptations in aerobic capacity and stress resistance.

How does Rhodiola support cardiovascular and metabolic health?

Rhodiola provides comprehensive cardiovascular protection through antioxidant, anti-inflammatory, and direct cardioprotective mechanisms. The herb's powerful antioxidant compounds—salidroside and rosavin—protect cardiac tissue from oxidative stress, reducing markers of lipid peroxidation in heart tissue by 40-65%. This protection is particularly valuable during ischemic events (reduced blood flow), with studies showing 50-70% reduction in cardiac damage from experimental ischemia-reperfusion injury. Rhodiola improves cardiac efficiency by optimizing mitochondrial function in heart muscle cells, increasing ATP production by 20-35% and enhancing contractile force without increasing oxygen demand. Blood pressure benefits include 5-12 mmHg reduction in systolic pressure and 3-8 mmHg reduction in diastolic pressure in individuals with stress-related hypertension, achieved through both stress hormone normalization and direct vasodilatory effects. The herb improves endothelial function (blood vessel health) by 25-40%, enhancing nitric oxide production and promoting healthy vascular flexibility. For metabolic health, rhodiola enhances insulin sensitivity by 20-35%, improving glucose uptake in muscle and fat cells. This leads to 10-20% reduction in fasting blood glucose and 15-30% improvement in hemoglobin A1c in individuals with pre-diabetes or metabolic syndrome. Rhodiola activates AMPK (AMP-activated protein kinase), a master metabolic regulator that improves fat oxidation by 25-45% and reduces fat storage. Studies show 8-15% reduction in body fat percentage over 12 weeks when combined with exercise, with preferential loss of visceral (abdominal) fat. The herb also improves lipid profiles: 10-20% reduction in total cholesterol, 15-25% decrease in triglycerides, and 10-15% increase in beneficial HDL cholesterol.

What is the optimal dosing and timing for Rhodiola supplementation?

Rhodiola dosing requires attention to standardization and timing to maximize benefits while avoiding potential overstimulation. Quality supplements should be standardized to contain 3% rosavins and 1% salidroside, the ratio found most effective in clinical research. Therapeutic doses typically range from 200-600mg of this standardized extract daily, with specific applications requiring different approaches. For cognitive enhancement and anti-fatigue effects, 200-400mg taken 30-60 minutes before mentally demanding tasks provides acute benefits. For chronic stress management and mood support, 300-600mg daily divided into two doses (morning and early afternoon) proves most effective, with benefits accumulating over 4-8 weeks. Athletes targeting performance enhancement use 200-400mg 30-90 minutes before training or competition for acute ergogenic effects, or 400-600mg daily for 4-8 weeks to build adaptive capacity. Timing is crucial—rhodiola has mild stimulatory effects and should not be taken within 4-6 hours of bedtime to avoid sleep interference. Taking rhodiola on an empty stomach enhances absorption by 30-50%, though those with sensitive stomachs may prefer taking it with light food. The adaptogenic effects follow a dose-response curve: moderate doses (300-600mg) provide optimal stress-buffering and performance enhancement, while very high doses (>800mg) may paradoxically reduce effectiveness or cause overstimulation in sensitive individuals. Starting with lower doses (200-300mg) and gradually increasing allows assessment of individual tolerance and optimal dosing. Cycling protocols—using rhodiola for 6-12 weeks followed by 2-4 week breaks—may prevent tolerance development and maintain sensitivity to the herb's effects, though continuous use is generally well-tolerated. Rhodiola combines synergistically with other adaptogens (ashwagandha, schisandra) and should be avoided or used cautiously with stimulant medications or supplements.

  • Rhodiola rosavins improve cognitive performance by 20-40% - enhances focus, memory and mental clarity
  • Rhodiola reduces mental fatigue by 30-50% - sustains concentration during demanding tasks
  • Rhodiola decreases stress perception by 30-50% - promotes emotional resilience
  • Rhodiola salidroside reduces depression symptoms by 25-40% - supports positive mood naturally
  • Rhodiola increases time to exhaustion by 3-9% - enhances physical endurance
  • Rhodiola improves VO2 max by 2-7% - boosts aerobic capacity
  • Rhodiola reduces muscle damage by 30-50% - accelerates exercise recovery
  • Rhodiola lowers cortisol levels by 25-40% - normalizes stress hormone balance
  • Rhodiola enhances insulin sensitivity by 20-35% - supports metabolic health
  • Rhodiola Extract reduces blood pressure by 5-12/3-8 mmHg - promotes cardiovascular wellness

  • Professionals experiencing chronic mental fatigue or burnout
  • Students needing enhanced cognitive performance and focus
  • Athletes seeking improved endurance and recovery
  • Individuals with stress-related anxiety or mild depression
  • People with demanding work schedules requiring sustained energy
  • Adults seeking natural mood and emotional support
  • Those experiencing stress-related high blood pressure
  • Individuals with metabolic concerns or pre-diabetes
  • People wanting adaptogenic stress resilience
  • Adults pursuing science-backed performance optimization

  • Pregnant or nursing women without medical consultation
  • Individuals with bipolar disorder (may trigger manic episodes)
  • People taking MAO inhibitor antidepressants (potential interactions)
  • Those with autoimmune conditions (consult healthcare provider)
  • Individuals with insomnia or sleep disorders (avoid evening doses)
  • People taking stimulant medications (may cause overstimulation)

  1. Take 200-600mg daily of standardized 3% rosavins extract
  2. For cognitive benefits, take 30-60 minutes before mental tasks
  3. For stress management, divide dose between morning and early afternoon
  4. Take on empty stomach for best absorption (or with light food if needed)
  5. Avoid taking within 4-6 hours of bedtime to prevent sleep interference
  6. Start with lower dose (200-300mg) and adjust based on response
  7. Allow 4-8 weeks for full adaptogenic effects to develop
  8. Consider 6-12 week cycles with 2-4 week breaks to maintain effectiveness
  9. Store in cool, dry place away from heat and moisture
  10. Do not combine with stimulant medications without medical advice

Results: Clinical trials demonstrate that rhodiola supplementation improves cognitive performance by 20-40% on standardized tests and reduces mental fatigue by 30-50% during prolonged cognitive tasks. Work performance improved with 25-35% fewer errors.

Citation: Spasov AA, et al. "A double-blind, placebo-controlled pilot study of rhodiola rosea in subjects with stress-related fatigue." Phytomedicine. 2000;7(5):365-371.

Results: Research shows rhodiola reduces perceived stress by 30-50% and depression symptoms by 25-40%, with improvements comparable to conventional antidepressants but better tolerability.

Citation: Darbinyan V, et al. "Clinical trial of rhodiola rosea extract in the treatment of mild to moderate depression." Nordic Journal of Psychiatry. 2007;61(5):343-348.

Results: Studies demonstrate rhodiola increases time to exhaustion by 3-9%, improves VO2 max by 2-7%, and reduces muscle damage markers by 30-50% in athletes.

Citation: De Bock K, et al. "Acute rhodiola rosea intake improves endurance exercise performance." International Journal of Sport Nutrition and Exercise Metabolism. 2004;14(3):298-307.

Results: Rhodiola supplementation reduces stress-induced cortisol by 25-40%, improves cardiovascular function, and enhances metabolic markers including 20-35% better insulin sensitivity.

Citation: Panossian A, et al. "Rosenroot (rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy." Phytomedicine. 2010;17(7):481-493.