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Science-based food supplements
Manufacturer: Life Extension
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NAD+ Cell Formula
300 mg, 30 vegetarian capsules
Item Catalog Number: 02344EU
NAD+ is a cellular coenzyme that’s found in every cell of our bodies and is necessary to create adenosine triphosphate (ATP), which the body uses for fuel. NAD+ Cell Formula can promote NAD+ levels in aging cells, thereby contributing to maintaining vitality and healthy energy levels.Benefits at a Glance:
First of all, what is NAD+? It's a cellular coenzyme that’s found in every cell of our bodies.
NAD+ is necessary to create adenosine triphosphate (ATP), the compound the body uses for fuel. The levels of NAD+ decline with age.
Many older people are experiencing fatigue and lack of motivation which might be because of an age-related decline in NAD+ levels [1] which can impair healthy cellular metabolism [2].
The active ingredient in this formula boosts NAD+ which promotes systemic youthful functions and can be found in every cell in the body [3].
As the body undergoes natural aging, one may experience having less energy and motivation to do different everyday tasks.
This may be due to declining levels of NAD (nicotinamide adenine dinucleotide). NAD+ Cell Formula can promote systemic youthful functions by providing nicotinamide riboside — a patented compound which plays a role in reversing age-related decline of NAD+ levels.
Found in every cell in the body, this enzyme plays a role in helping to maintain healthy cell metabolism. With the highly innovative NAD+ Cell Formula, there is finally a product designed to promote higher NAD+ enzyme levels for refreshed vitality.
Nicotinamide riboside can increase cellular levels of NAD+ in the body [4,5]. Nicotinamide riboside has been shown to help replenish cellular NAD+ and can:
Serving Size 1 vegetarian capsule
| Amount Per Serving | |
|---|---|
| Niacin From NIAGEN® Nicotinamide Riboside (300 mg) | 126 mg |
| Ingredients: Nicotinamide riboside chloride, bulking agent (microcrystalline cellulose/cellulose gel), capsule (hydroxypropylmethylcellulose), anti-caking agents (silicon dioxide [nano], magnesium salts of fatty acids) | |
Non-GMO
NIAGEN® is a registered trademark of ChromaDex, Inc., Patents see: www.ChromaDexPatents.com.
Dosage and Use
Take one (1) capsule daily with or without food
Caution
For adults only. Do not use in case of pregnancy or breastfeeding.
Warnings
KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell that is essential for energy production, DNA repair, and cellular communication. NAD+ levels decline significantly with age, dropping by up to 50% by age 60, contributing to many age-related health concerns. This coenzyme is critical for mitochondrial function and ATP production, the cell's energy currency. NAD+ also activates sirtuins, longevity proteins that regulate cellular health, stress resistance, and metabolic function. Declining NAD+ levels are associated with reduced cellular energy, impaired DNA repair, mitochondrial dysfunction, and accelerated aging processes throughout the body.
NAD+ Cell Formula provides nicotinamide riboside (NR), a precursor that cells efficiently convert into NAD+. Unlike direct NAD+ supplementation which is poorly absorbed, NR is readily taken up by cells and converted through the salvage pathway into active NAD+. Clinical studies show NR supplementation can increase NAD+ levels by 40-60% within weeks. The 300 mg dose provides clinically effective amounts shown in research to elevate cellular NAD+ concentrations. Once converted to NAD+, this coenzyme supports mitochondrial function, activates sirtuins, enhances DNA repair mechanisms, and promotes healthy cellular metabolism throughout the body.
Elevating NAD+ levels supports multiple aspects of health and healthy aging. Many users report increased energy and reduced fatigue as mitochondrial function improves. NAD+ supports cardiovascular health by promoting healthy blood vessel function and cellular energy in heart muscle. Cognitive function and mental clarity may improve through enhanced neuronal energy production and neuroprotection. NAD+ supports healthy metabolic function including blood sugar metabolism and weight management. The coenzyme promotes cellular repair and resilience to stress. Research suggests NAD+ elevation may support muscle function, exercise performance, and recovery. Long-term NAD+ support may help maintain cellular health and promote healthy longevity.
Sirtuins are a family of seven proteins (SIRT1-7) that regulate cellular health, stress resistance, and longevity. These proteins require NAD+ to function—without adequate NAD+, sirtuins cannot perform their protective roles. Sirtuins regulate gene expression, DNA repair, inflammation, mitochondrial function, and cellular metabolism. Research shows sirtuin activation mimics benefits of caloric restriction, a proven longevity intervention. By boosting NAD+ levels, you provide sirtuins with the fuel they need to protect cells, maintain metabolic health, support cardiovascular function, and promote healthy aging. This NAD+-sirtuin axis is considered one of the most important cellular pathways for longevity and healthspan.
For best results, take NAD+ Cell Formula in the morning with or without food, as NAD+ supports energy metabolism and some people find it energizing. The 300 mg dose has been shown in clinical studies to effectively elevate NAD+ levels when taken daily. Consistency is key—maintain daily supplementation for at least 4-8 weeks to experience full benefits as cellular NAD+ pools replenish. Some people split the dose, taking half in morning and half early afternoon. Avoid taking late in the day if you're sensitive to energy-supporting supplements. NAD+ Cell Formula works synergistically with other longevity nutrients like resveratrol, pterostilbene, and CoQ10 for comprehensive cellular support.
Results: Clinical trials demonstrate nicotinamide riboside supplementation increases NAD+ levels by 40-60% in human subjects within 2-4 weeks, with sustained elevation maintained during continued supplementation, effectively restoring age-related NAD+ decline.
Citation: Martens CR, et al. Nat Commun. 2018 Mar;9(1):1286.
Results: Research shows NAD+ boosting activates sirtuins and improves mitochondrial function, with studies demonstrating enhanced cellular energy production, improved insulin sensitivity, and better metabolic health markers in supplemented individuals compared to placebo groups.
Citation: Rajman L, et al. Cell Metab. 2018 Mar;27(3):529-547.
Results: Studies indicate NAD+ elevation supports cardiovascular health, with clinical trials showing improvements in blood vessel function, arterial stiffness, and blood pressure in middle-aged and older adults after 6-8 weeks of nicotinamide riboside supplementation.
Citation: Elhassan YS, et al. NPJ Aging Mech Dis. 2019 Nov;5:16.
Results: Clinical research demonstrates NAD+ precursor supplementation supports cognitive function and neuroprotection, with animal studies showing preserved neuronal NAD+ levels, improved mitochondrial function in brain tissue, and enhanced cognitive performance with aging.
Citation: Gong B, et al. Proc Natl Acad Sci USA. 2013 Jun;110(24):9781-6.