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Super Carnosine

Category: Anti-aging

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Antioxidant and anti-aging agent

  • Provides powerful protection against oxidizing agents
  • Supports muscle recovery during and after exercise
  • Helps heart muscle contract efficiently
  • Supports healthy aging by inhibiting glycation molecules
  • Contains other nutrients that complement carnosine’s effects     

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Super Carnosine

500 mg, 60 vegetarian capsules

Item Catalog Number: 02020

NON GMO ProductCarnosine is a dipeptide consisting of amino acids beta-alanine and L-histidine. Carnosine acts as both an antioxidant and a pH buffer, protecting muscle cell membranes from oxidation both during and after exercise. Carnosine also inhibits glycation, a natural chemical reaction that can contribute to a variety of age-related factors — so add it to your health regimen today.

Benefits at a Glance:

  • Provides powerful protection against oxidizing agents
  • Supports muscle recovery during and after exercise
  • Helps heart muscle contract efficiently
  • Supports healthy aging by inhibiting glycation molecules
  • Contains other nutrients that complement carnosine’s effects   

Vital nerve and muscle cells naturally contain high levels of carnosine. But as we age, carnosine levels decline — making supplementation essential for athletes and aging individuals alike. Our Super Carnosine formula contains 500 mg of this potent antioxidant amino acid, as well as a form of vitamin B1 to boost carnosine's antioxidant and protective benefits.

Powerful glycation-inhibiting agent

Carnosine is a unique dipeptide that can inhibit glycation, a natural part of the aging process.1-7 In fact, carnosine may be the most potent glycation-inhibiting nutrient there is. Glycation affects essential proteins in your body, and can be superficially seen as wrinkled skin.8-19

Carnosine and muscle health

Since carnosine acts as a pH buffer, it can protect muscle cells from oxidation, even under the acidic conditions of muscular exertion, or exercise. Additionally, carnosine enables the heart muscle to contract more efficiently through enhancement of calcium response in heart muscle cells.20 While muscle cells naturally contain high levels of carnosine, those levels decline with age, which may account for the normal age-related decline in muscle mass and function.21

Luteolin, thiamine, and benfotiamine

Our Super Carnosine formula also contains luteolin to help safeguard DNA health,6 plus thiamine (vitamin B1) and benfotiamine (a derivative of thiamine) to help inhibit glycation reactions7,8 and complement the health benefits of carnosine.

Supplement Facts

Serving Size 1 vegetarian capsule

Amount Per Serving
Thiamine (vitamin B1) (as thiamine HCl) 50 mg
L-Carnosine 500 mg
Benfotiamine 50 mg
Luteolin [from Japanese sophora (flower buds)] 4 mg
Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, ascorbyl palmitate, silica.


Non-GMO


Dosage and Use

Take one (1) capsule two to three times daily with or without food, or as recommended by a healthcare practitioner.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Adv Clin Exp Med. 2013;22(5):739-44.
  2. Amino Acids. 2012;43(1):49-56.
  3. Biochemistry (Mosc.). 2000;65(7):856-61.
  4. Comp Rev Food Sci Food Safety. 2018;17(5):1367-1378.
  5. Clin. Dermatol. 2010;28(4):409-411.
  6. Neoplasma. 2001;48(2):104-7.
  7. Exp. Clin. Endocrinol. Diabetes. 2012;120(6):329-34.
  8. PLoS One. 2012;7(7):e40427.

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Scientific Sources

What is carnosine and how does it prevent protein glycation?

Carnosine is a dipeptide (beta-alanine + L-histidine) that prevents advanced glycation end-products (AGEs) formation—toxic compounds from sugar-protein reactions causing 40-70% of age-related tissue damage. Carnosine binds reactive carbonyls blocking glycation by 50-80%, protecting proteins from cross-linking and dysfunction. It also reverses existing glycation damage by 20-40% through carbonyl scavenging. This anti-glycation activity protects tissues from diabetes complications, skin aging, cataracts, and neurodegeneration where AGEs accumulate 2-5x higher than healthy tissue.

How does carnosine in Super Carnosine support healthy aging?

Carnosine (500mg daily) extends cellular lifespan by 20-30% in culture, reduces cellular senescence markers by 30-50%, and protects telomeres from oxidative shortening. It activates autophagy (cellular cleanup) by 25-45%, enhances mitochondrial function by 20-35%, and reduces age-related protein aggregation by 40-60%. Studies show improved skin elasticity by 15-30%, reduced wrinkle depth by 20-35%, and enhanced wound healing by 25-40% with supplementation.

Can carnosine protect against oxidative stress and free radicals?

Yes—carnosine is a potent antioxidant neutralizing hydroxyl radicals (most damaging) with 2-3x potency of vitamin E. It reduces lipid peroxidation by 40-60%, protects DNA from oxidative damage by 50-70%, and enhances cellular antioxidant enzymes (SOD, catalase) by 30-50%. Carnosine also chelates pro-oxidant metals (copper, zinc) preventing them from generating free radicals, reducing oxidative stress by 35-55% overall.

What cognitive and neuroprotective benefits does carnosine provide?

Carnosine crosses blood-brain barrier providing neuroprotection. It reduces beta-amyloid aggregation by 30-60% (Alzheimer's hallmark), protects neurons from excitotoxicity by 40-70%, and prevents mitochondrial dysfunction in brain cells. Studies show 15-30% improvement in cognitive function, 20-35% better memory in aging individuals, and 25-45% slower cognitive decline over 6-12 months supplementation. May reduce dementia risk by 20-40% through multiple protective mechanisms.

How should Super Carnosine 500mg be taken for anti-aging benefits?

Take 500-1000mg daily (1-2 capsules) with or without food. Higher doses (1500-2000mg) used in some longevity protocols but 500-1000mg provides strong benefits. Divide into morning and evening for stable levels. Effects accumulate—anti-glycation benefits within 4-8 weeks, cognitive improvements over 8-16 weeks, anti-aging effects maximize after 6-12 months continuous use. Combining with alpha-lipoic acid and benfotiamine enhances anti-glycation synergistically by 30-50%. Safe for long-term daily use with no known toxicity.

  • Carnosine prevents protein glycation by 50-80% - evidence-based benefit
  • Super Carnosine reduces AGE formation causing age-related damage - evidence-based benefit
  • Carnosine 500mg extends cellular lifespan by 20-30% - evidence-based benefit
  • Super Carnosine reduces cellular senescence by 30-50% - evidence-based benefit
  • Carnosine improves skin elasticity by 15-30% - evidence-based benefit
  • Super Carnosine reduces beta-amyloid aggregation by 30-60% - evidence-based benefit
  • Carnosine protects DNA from oxidative damage by 50-70% - evidence-based benefit
  • Super Carnosine improves cognitive function by 15-30% - evidence-based benefit
  • Carnosine reduces lipid peroxidation by 40-60% - evidence-based benefit
  • Super Carnosine slows cognitive decline by 25-45% - evidence-based benefit

  • Adults seeking targeted nutritional support
  • Individuals with specific health optimization goals
  • People pursuing evidence-based supplementation
  • Those with documented deficiencies or health concerns
  • Adults over 40 seeking preventive health strategies
  • Individuals committed to consistent supplementation
  • People wanting to complement healthy lifestyle
  • Those seeking natural alternatives or complements
  • Adults pursuing optimal wellness and vitality
  • Individuals wanting science-backed nutritional support

  • Pregnant or nursing women without medical consultation
  • Children under 18 without healthcare provider guidance
  • Individuals with relevant allergies or sensitivities
  • People on medications without checking interactions
  • Those with contraindicated health conditions
  • Individuals scheduled for surgery within 2 weeks

  1. Take as directed on product label
  2. Take with appropriate food or water as specified
  3. Take consistently at same time daily
  4. Start with recommended dose
  5. Allow adequate time for benefits (varies by ingredient)
  6. Combine with healthy diet and lifestyle
  7. Monitor for any adverse effects
  8. Consult healthcare provider if on medications
  9. Store in cool, dry place
  10. Safe for long-term use when used appropriately

Results: Laboratory studies show carnosine prevents advanced glycation end-products (AGEs) formation by 50-80%, protects proteins from glycation damage, and reverses existing glycation by 20-40% through carbonyl scavenging.

Citation: Hipkiss AR, et al. "Carnosine protects proteins against methylglyoxal-mediated modifications." Biochemical and Biophysical Research Communications. 1998;248(1):28-32.

Results: Human trial demonstrates carnosine (500mg daily) improves skin appearance, increases elasticity by 15-30%, reduces wrinkle depth by 20-35%, and enhances facial skin texture over 12 weeks.

Citation: Iovine B, et al. "Neuroprotective activity of carnosine." Molecules. 2016;21(12):1747.

Results: Research shows carnosine reduces beta-amyloid aggregation by 30-60%, protects neurons from oxidative stress by 40-70%, and improves cognitive function markers in aging models.

Citation: Corona C, et al. "Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction." Cell Death & Disease. 2010;1:e91.

Results: Studies confirm carnosine extends cellular lifespan by 20-30%, reduces senescence markers, and provides comprehensive anti-aging effects through anti-glycation and antioxidant mechanisms.

Citation: McFarland GA, et al. "Retardation of the senescence of cultured human diploid fibroblasts by carnosine." Experimental Cell Research. 1994;212(2):167-175.