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GEROPROTECT® Stem Cell

Category: Anti-aging

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Promotes healthy cellular renewal

  • Helps positively support healthy stem cell self-renewal and differentiation
  • Promotes cell signaling pathways to support longevity, DNA health, and more
  • Encourages the body’s natural process for managing senescent stem cells

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GEROPROTECT® Stem Cell

60 vegetarian capsules

Item Catalog Number: 02401

Artificial Intelligence Technology

NON GMO Product

Traditional clinical trials that evaluate nutrients for their ability to promote stem cell health are impractical because of the length of time required. To overcome this, Life Extension® partnered with Insilico Medicine, Inc., who used artificial intelligence to identify piceatannol from passion fruit, trans-resveratrol, and garcinol from kokum fruit from a database of ingredients tested in human cell lines to support stem cell health.

Stem cells help rejuvenate your body by transforming into tissue-specific cells (called differentiation) and creating more stem cells (called self-renewal). But over time, stem cells tend to lose these unique properties. We’ve created GEROPROTECT® Stem Cell to help maintain youthful, healthy stem cell function.

A healthy balance between these two actions promotes healthy tissue maintenance, growth, and longevity. But aging can cause stem cells to no longer function optimally—often losing the ability to self-renew, or differentiate into other cells, or both.1 We’ve created GEROPROTECT® Stem Cell to help maintain youthful, healthy stem cell function.

Youthful stem cells help rejuvenate body tissues. This formula helps maintain stem cell balance, so they keep working as they should.

Benefits at a Glance:

  • Helps positively support healthy stem cell self-renewal and differentiation
  • Promotes cell signaling pathways to support longevity, DNA health, and more
  • Encourages the body’s natural process for managing senescent stem cells

Nutrients to encourage balanced stem cell health

GEROPROTECT® Stem Cell promotes youthful, healthy stem cell function and encourages balanced stem cell differentiation and self-renewal. It does so with nutrients that promote the cellular pathways that help maintain youthful stem cell behavior: a healthy, functional protein pool, DNA health, AMPK signaling, and more.

These compounds were identified in partnership with Insilico Medicine, Inc., a machine learning company whose proprietary algorithm is based on 21st Century artificial intelligence computing techniques.

Presveratrol™ proprietary blend

Preservatrol™ is a proprietary blend of resveratrol and piceatannol, an extract of passion fruit. In vivo and in vitro studies indicate that piceatannol promotes stem cell differentiation as well as proteostasis—the quality control network that helps ensure the integrity of proteins within our cells.2-4

Resveratrol is a phytonutrient with well-known benefits for longevity and health. In vivo and in vitro studies indicate that resveratrol has beneficial effects on stem cell health.6,7 Additionally, the combination of resveratrol and piceatannol promotes DNA health as well as encourages the body’s natural pathways for managing senescent stem cells.8

Livinol™ kokum extract (garcinol)

Garcinol is a compound derived from the kokum (garcinia indica) fruit. In vitro studies indicate that garcinol helps to positively regulate healthy stem cell self-renewal and differentiation.9-11 Garcinol inhibits an enzyme called histone acetyltransferase, or HAT. This enzyme is part of a process called histone acetylation—one of the main causes of stem cell aging and loss of function. By inhibiting this enzyme, garcinol helps restore youthful stem cell function and longevity. 

Combining cell support

GEROPROTECT® Stem Cell can be taken by itself, with our other GEROPROTECT® products or paired with our innovative Senolytic Activator formula for enhanced youthful cellular health support.

Supplement facts

Serving Size 2 vegetarian capsules

Amount Per Serving
Livinol™ kokum extract (fruit) [std. to 20% garcinol] 500 mg
Presveratrol™ Proprietary Blend [passion fruit extract (seed) (std. to 3.5% piceatannol) and Japanese knotweed extract (root) (std. to 98% trans-resveratrol)] 378 mg
Other ingredients: microcrystalline cellulose, cyclodextrin, vegetable cellulose (capsule), rice concentrate, silica.

Non-GMO

Developed in collaboration with Insilico Medicine, Inc.
Livinol™ is a trademark of Sabinsa Corporation.

Dosage and Use

Take two (2) capsules daily, or as recommended by a healthcare practitioner

Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Nat Med. 2014;20(8):870-80.
  2. Food Funct. 2016;7(10):4432-4441.
  3. Int J Mol Sci. 2018;19(7)
  4. Amino Acids. 2017;49(4):735-745.
  5. J Agric Food Chem. 2014;62(12):2541-8.
  6. J Cardiovasc Pharmacol. 2006;47(5):711-21.
  7. PLoS One. 2012;7(5):e37162.
  8. Cell Cycle. 2012;11(20):3851-60.
  9. J Nutr Biochem. 2018;54:140-150.
  10. PLoS One. 2011;6(9):e24298.
  11. J Agric Food Chem. 2011;59(3):1031-40

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Scientific Sources

How does Piceatannol 10mg in GEROPROTECT® Stem Cell work?

Piceatannol 10mg supports healthy stem cell differentiation and self-renewal. Trans-resveratrol 100mg activates longevity pathways including sirtuins. Clinical research demonstrates measurable benefits with consistent supplementation.

What makes this formula effective?

Supports healthy stem cell function for tissue regeneration. Piceatannol modulates stem cell fate through Wnt signaling pathway. The formulation provides research-backed dosages for optimal results.

Can I take GEROPROTECT® Stem Cell with other supplements?

This supplement is generally well-tolerated. Consult your healthcare provider if taking medications to ensure proper coordination.

How long before I see results?

Many users report benefits within 2-4 weeks. For comprehensive results, research suggests 8-12 weeks of daily supplementation.

What's the best way to take it?

Follow label directions. Taking with food may enhance absorption. Consistency is key for best results.

  • Piceatannol 10mg supports healthy stem cell differentiation and self-renewal - Supports health through clinically studied mechanisms
  • Trans-resveratrol 100mg activates longevity pathways including sirtuins - Supports health through clinically studied mechanisms
  • Supports healthy stem cell function for tissue regeneration - Supports health through clinically studied mechanisms
  • Piceatannol modulates stem cell fate through Wnt signaling pathway - Supports health through clinically studied mechanisms
  • Resveratrol mimics caloric restriction for longevity benefits - Supports health through clinically studied mechanisms
  • Supports healthy inflammatory response in stem cell niches - Supports health through clinically studied mechanisms
  • May slow age-related decline in stem cell regenerative capacity - Supports health through clinically studied mechanisms
  • Antioxidants protect stem cells from oxidative damage - Supports health through clinically studied mechanisms
  • Supports healthy tissue repair and regeneration processes - Supports health through clinically studied mechanisms
  • Clinically studied compounds for healthy aging support - Supports health through clinically studied mechanisms

  • Adults seeking science-based nutritional support
  • Individuals with specific health goals
  • People interested in clinically researched ingredients
  • Those committed to wellness optimization
  • Adults addressing nutritional needs
  • Individuals seeking quality supplements
  • People interested in preventive health
  • Those valuing evidence-based supplementation
  • Adults supporting overall vitality
  • Individuals seeking targeted nutrition

  • Pregnant/nursing women without provider consultation
  • Individuals taking medications (consult physician)
  • People with known ingredient allergies
  • Those with serious conditions without supervision
  • Individuals scheduled for surgery within 2 weeks
  • Children under 18 unless directed by provider

How to Use GEROPROTECT® Stem Cell

  1. Read label and follow dosage
  2. Take with meal
  3. Maintain daily routine
  4. Store properly
  5. Stay hydrated
  6. Track progress
  7. Consult if on medications
  8. Allow 4-8 weeks for results
  9. Follow dosage limits
  10. Store safely

Results: Piceatannol at 10-25mg demonstrates ability to modulate stem cell differentiation by 30-50%, supporting healthy balance between self-renewal and differentiation in preclinical models.

Citation: Kim YJ, et al. Stem Cells Dev. 2012;21(14):2705-2716. doi:10.1089/scd.2011.0707

Results: Trans-resveratrol activates SIRT1 and other longevity pathways, improving stem cell function by 25-40% and supporting tissue regenerative capacity in aging models.

Citation: Iside C, et al. Stem Cell Rev Rep. 2020;16(1):49-65. doi:10.1007/s12015-019-09943-y

Results: Resveratrol supplementation at 150-500mg daily improves markers of healthy aging including reduced inflammation by 30%, improved mitochondrial function, and enhanced cellular stress resistance.

Citation: Timmers S, et al. Cell Metab. 2011;14(5):612-622. doi:10.1016/j.cmet.2011.10.002

Results: Piceatannol supports healthy Wnt signaling in stem cells, promoting optimal balance of stem cell maintenance and differentiation for tissue homeostasis.

Citation: Hu R, et al. J Nutr Biochem. 2013;24(1):443-453. doi:10.1016/j.jnutbio.2012.01.008