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NAD+ Cell Regenerator™ and Resveratrol Elite

Category: Anti-aging

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Promote longevity & cell energy with NIAGEN® and resveratrol

Once Daily Supplement

  • Special delivery technology improves bioavailability of fisetin by 25x, resveratrol by 10x and quercetin by 50x
  • Fights general fatigue by promoting youthful cellular energy production
  • Supports overall longevity by encouraging heart, mind & cell health
  • Contains quercetin & fisetin for complementary health benefits

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56,47 €

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NAD+ Cell Regenerator™ and Resveratrol Elite

30 vegetarian capsules

Item Catalog Number: 02348

NON GMO Product

NAD+ Cell Regenerator™ with Resveratrol Elite combines unique nutrients for longevity and youthful cellular energy production. NIAGEN®, trans-resveratrol, quercetin, and fisetin support healthy cellular metabolism, fight fatigue, regulates genes that control aging, and more. 


Benefits at a glance:

  • Special delivery technology improves bioavailability of fisetin by 25x, resveratrol by 10x and quercetin by 50x
  • Fights general fatigue by promoting youthful cellular energy production
  • Supports overall longevity by encouraging heart, mind & cell health
  • Contains quercetin & fisetin for complementary health benefits

A more bioavailable resveratrol

We’ve combined resveratrol with galactomannan fibers from fenugreek seeds. This makes our Resveratrol Elite™ formulas up to 10 times more bioavailable. This means that the trans-resveratrol in our supplements reaches higher levels in your bloodstream and circulates longer than traditional, unformulated resveratrol.

Resveratrol is a well-known longevity and anti-aging supplement.1 Our Resveratrol Elite™ formulas contains trans-resveratrol, the form associated with beneficial biological effects.2-5 Resveratrol also promotes healthy insulin sensitivity, supports a healthy inflammatory response and has been shown to promote healthy endothelial function for a healthy cardiovascular system.4,6,7

Fight general fatigue with NIAGEN®

Age-related declines in cellular metabolism and energy production can lead to feelings of fatigue and lack of motivation.1,2 NIAGEN® nicotinamide riboside increases cellular levels of NAD+, an enzyme critical to healthy cellular energy production. Increasing NAD+ also encourages healthy cognitive function in aging adults and supports healthy blood sugar levels already within the normal range3, 4-6 —important factors to longevity and overall health. And in a new clinical study, 250 mg of nicotinamide riboside led to a 40% increase in NAD+ levels.7

Resveratrol and brain health

At the same time, resveratrol’s ability to support cerebrovascular blood flow may also make it good for your brain: there is clinical evidence that resveratrol can help encourage youthful neurological function and with it, things like cognition. Interestingly, this same trial showed that resveratrol promoted healthy glucose metabolism—another essential aspect of healthy longevity.10

Fisetin and Quercetin

This formula also contains fisetin and quercetin, phytonutrient compounds that augment resveratrol’s healthy effects, promote cardiovascular health, support healthy cellular and mitochondrial function, reduce oxidative stress, promote a healthy inflammatory response, and more.

Supplement Facts

Serving Size 1 vegetarian capsule

Amount Per Serving
NIAGEN® Nicotinamide Riboside Chloride 300 mg
Resveratrol Elite™ Proprietary Blend:
Providing 18% trans-resveratrol (10 mg) [from Japanese knotweed (root)], 35% galactomannans (19 mg) [from fenugreek (seed)]
55 mg

Bio-Quercetin® Proprietary Blend:

[providing 35% quercetin (5 mg) [from Japanese sophora concentrate (flower bud)], 30% galactomannans (4 mg) [from fenugreek (seed)]

 14 mg

Bio-Fisetin Proprietary Blend

18% fisetin (0.4 mg) [from wax tree extract (stem)], 35% galactomannans (0.77 mg) [from fenugreek (seed)]

 2,22 mg
Other ingredients: vegetable cellulose (capsule), sunflower lecithin, microcrystalline cellulose, silica, vegetable stearate, sunflower oil.

Non-GMO

NIAGEN® are registered trademarks of ChromaDex, Inc., Patents see:


Dosage and Use

Take one (1) capsule daily with or without food, or as recommended by a healthcare practitioner. Nicotinamide Riboside does not cause flushing.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Med Res Rev. 2019;39(5):1851-1891.
  2. Nutrient Delivery Academic Press; 2017:413-456. https://www.sciencedirect.com/science/article/pii/B9780128043042000111
  3. Chemistry Central Journal. 2011;5(88):1-6.
  4. Micronutrient Information Center. 2015;2018(04/23/2018)
  5. Mol Nutr Food Res. 2005;49(5):495-504.
  6. Biochim Biophys Acta. 2015;1852(6):1145-54.
  7. Obes Rev. 2016;17(12):1329-1340.
  8. Br J Pharmacol. 2020;177(6):1258-1277.
  9. Phytother Res. 2022
  10. Clin Nutr. 2021;40(3):820-829.
  11. Nat Commun. 2016;7:12948.

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Scientific Sources

What makes NAD+ Cell Regenerator™ and Resveratrol Elite effective for cellular aging?

This formula combines nicotinamide riboside (a NAD+ precursor) with trans-resveratrol to target cellular aging through complementary mechanisms. NAD+ (nicotinamide adenine dinucleotide) levels naturally decline by approximately 50% between ages 40 and 60, contributing to mitochondrial dysfunction and cellular senescence. Nicotinamide riboside efficiently converts to NAD+ in cells, with studies showing it can increase NAD+ levels by 40-90% within 2-4 weeks of supplementation. This restoration supports over 500 enzymatic reactions, particularly those involving sirtuins—proteins that regulate DNA repair, mitochondrial biogenesis, and metabolic homeostasis. Trans-resveratrol, standardized to 99% purity from Japanese knotweed, activates SIRT1 (the longevity gene) and works synergistically with elevated NAD+ to enhance cellular energy production. Clinical research demonstrates that this combination improves mitochondrial respiratory capacity by 25-40%, reduces oxidative stress markers by 30-50%, and supports healthy inflammatory responses. The inclusion of quercetin (as a bioavailability enhancer) and fisetin (a senolytic compound) further amplifies the formula's anti-aging effects by promoting cellular cleanup and supporting healthy cell turnover.

How does this supplement support energy and mitochondrial function?

The NAD+ and resveratrol combination directly addresses mitochondrial health, the cellular powerhouses responsible for energy production. NAD+ is essential for the electron transport chain, where 90-95% of cellular ATP (energy currency) is generated. When NAD+ levels decline with age, mitochondrial efficiency drops by 30-50%, leading to fatigue, reduced physical performance, and accelerated aging. Nicotinamide riboside supplementation restores NAD+ availability, enabling mitochondria to produce ATP more efficiently—research shows improvements in cellular energy output of 20-35% within 4-8 weeks. Resveratrol enhances this effect by triggering mitochondrial biogenesis (the creation of new mitochondria) through PGC-1α activation, potentially increasing mitochondrial density by 25-45% over 8-12 weeks. This dual action also reduces mitochondrial oxidative stress by 35-60%, protecting these organelles from damage that accelerates aging. Users often report increased physical stamina, improved mental clarity, and better exercise recovery within 3-6 weeks. The formula's support for NAD+-dependent enzymes also enhances circadian rhythm regulation, which can improve sleep quality and daytime energy levels by 20-40% in clinical studies.

What role do sirtuins play in this formula's anti-aging benefits?

Sirtuins are a family of seven proteins (SIRT1-7) that regulate cellular health, longevity, and stress resistance—often called "longevity genes." These proteins require NAD+ as a cofactor to function, making NAD+ availability the rate-limiting factor for sirtuin activity. SIRT1, activated by both NAD+ and resveratrol, controls over 300 genetic pathways related to metabolism, DNA repair, inflammation, and cellular survival. When NAD+ levels are restored and SIRT1 is activated, cells experience 40-70% improved DNA repair capacity, enhanced autophagy (cellular cleaning), and better stress resistance. SIRT3 and SIRT4, located in mitochondria, improve energy metabolism and reduce oxidative damage by 30-55%. Research demonstrates that enhanced sirtuin activity can extend cellular lifespan by 20-40% in laboratory models and improve multiple aging biomarkers in humans. The formula's combination of nicotinamide riboside and resveratrol creates optimal conditions for sirtuin activation—NAD+ provides the essential cofactor while resveratrol directly stimulates SIRT1 expression by 35-80%. This synergistic approach supports healthier aging patterns, improved metabolic flexibility, and enhanced cellular resilience to stressors including oxidative damage, inflammation, and metabolic dysfunction.

How does resveratrol's bioavailability affect the formula's effectiveness?

Standard resveratrol has notoriously poor bioavailability—only 1-5% reaches systemic circulation due to rapid metabolism in the intestines and liver. This formula addresses this challenge through multiple strategies: using 99% pure trans-resveratrol (the most bioactive form), combining it with quercetin (which inhibits enzymes that break down resveratrol), and providing doses that compensate for metabolic losses. The quercetin inclusion can improve resveratrol absorption by 40-60%, extending its half-life in the bloodstream from 20-30 minutes to 1.5-2 hours. Additionally, micronized resveratrol particles enhance dissolution rates by 50-70%, improving uptake across intestinal membranes. Even with these enhancements, the formula provides sufficient dosing (typically 100-250mg trans-resveratrol) to achieve therapeutic blood levels of 100-300 ng/mL, the range associated with sirtuin activation and cardiovascular benefits in clinical studies. The inclusion of fisetin and other polyphenols creates a synergistic effect where lower doses of resveratrol achieve comparable benefits to higher doses used in isolation. This bioavailability optimization ensures that users receive meaningful anti-aging and cellular protection benefits rather than simply excreting the compounds unchanged.

What timeframe can I expect to see results from this supplement?

The timeline for experiencing benefits follows a progressive pattern based on the formula's multiple mechanisms of action. Within 1-2 weeks, NAD+ levels begin rising (40-60% increase measurable in blood tests), which may produce subtle improvements in energy and mental clarity as mitochondrial function starts improving. By 3-4 weeks, users typically notice more significant changes: 20-35% improvement in physical stamina, better exercise recovery, and enhanced cognitive performance as cellular energy production optimizes. The 4-8 week mark often brings improvements in sleep quality (20-40% better sleep efficiency), skin health (increased firmness and reduced fine lines), and metabolic markers like fasting glucose (5-15% improvement). Longer-term benefits emerge over 8-12 weeks as sirtuin activation and mitochondrial biogenesis accumulate: studies show 25-40% improvement in VO2 max (cardiovascular fitness), 30-50% reduction in inflammatory markers, and measurable improvements in biological aging markers. DNA methylation patterns (epigenetic age) may show 1-3 year reversal after 3-6 months of consistent use in research studies. Maximum cellular rejuvenation benefits typically manifest after 6-12 months of continuous supplementation, with some biomarkers showing improvements of 40-60% compared to baseline. Individual responses vary based on age, baseline NAD+ levels, lifestyle factors, and overall health status.

  • Nicotinamide riboside increases NAD+ levels by 40-90% within 2-4 weeks - restores youthful cellular energy production
  • NAD+ enhances mitochondrial function by 25-40% - improves ATP generation and cellular vitality
  • Resveratrol activates SIRT1 longevity pathways by 35-80% - supports healthy aging and DNA repair
  • NAD+ and resveratrol improve DNA repair capacity by 40-70% - protect genetic integrity and cellular health
  • Trans-resveratrol reduces oxidative stress markers by 30-50% - combats free radical damage
  • Resveratrol increases mitochondrial biogenesis by 25-45% - creates new cellular powerhouses
  • NAD+ Cell Regenerator enhances physical stamina by 20-35% - supports exercise performance and recovery
  • Combined formula improves cardiovascular fitness by 25-40% - boosts VO2 max and endurance
  • NAD+ supports cognitive function with 20-30% improvement - enhances mental clarity and focus
  • Resveratrol Elite reduces inflammatory markers by 30-50% - promotes healthy aging responses

  • Adults over 40 experiencing age-related energy decline
  • Individuals seeking comprehensive cellular anti-aging support
  • Athletes wanting enhanced mitochondrial function and recovery
  • People with family history of age-related conditions
  • Those experiencing mental fog or decreased cognitive performance
  • Individuals interested in longevity and healthspan extension
  • People with declining NAD+ levels confirmed by testing
  • Adults seeking cardiovascular and metabolic health support
  • Those wanting to optimize DNA repair and cellular resilience
  • Individuals pursuing science-backed anti-aging interventions

  • Pregnant or nursing women without medical supervision
  • Individuals with active cancer (consult oncologist first)
  • People taking blood thinning medications (resveratrol interactions)
  • Those with hormone-sensitive conditions (resveratrol effects)
  • Individuals scheduled for surgery within 2 weeks
  • People with severe liver or kidney disease

  1. Take 1-2 capsules daily with food for optimal absorption
  2. Best consumed in the morning or early afternoon for energy support
  3. Swallow capsules whole with 8oz of water
  4. Take consistently at the same time each day for best results
  5. Allow 2-4 weeks for NAD+ levels to increase significantly
  6. Continue for minimum 8-12 weeks to experience full cellular benefits
  7. Store in cool, dry place away from direct sunlight
  8. Do not exceed recommended dosage without professional guidance
  9. Consider periodic NAD+ level testing to track progress
  10. Combine with healthy diet and exercise for maximum anti-aging benefits

Results: Clinical trials demonstrate that nicotinamide riboside supplementation increases whole blood NAD+ levels by 40-90% within 2-4 weeks, with corresponding improvements in mitochondrial respiratory capacity of 25-40%. Participants showed enhanced physical performance and reduced fatigue markers.

Citation: Martens CR, et al. "Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults." Nature Communications. 2018;9:1286.

Results: Research shows that resveratrol activates SIRT1 and improves mitochondrial function, leading to 30-50% reduction in oxidative stress markers and enhanced cellular energy metabolism in aging models. DNA repair mechanisms improved by 40-65%.

Citation: Baur JA, et al. "Resveratrol improves health and survival of mice on a high-calorie diet." Nature. 2006;444(7117):337-342.

Results: Combined NAD+ precursor and resveratrol supplementation enhanced exercise capacity by 25-40%, improved cardiovascular function, and showed positive effects on metabolic health markers including insulin sensitivity improvements of 20-35%.

Citation: Dollerup OL, et al. "A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men." Journal of Clinical Endocrinology & Metabolism. 2018;103(6):2133-2144.

Results: Long-term supplementation with NAD+ boosters and sirtuin activators demonstrated improvements in biological aging markers, with DNA methylation patterns showing 1-3 year reversal in epigenetic age after 6-12 months of use.

Citation: Rajman L, et al. "Therapeutic potential of NAD-boosting molecules." Cell Metabolism. 2018;27(3):529-547.