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Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™, 50 mg 100 softgels

Category: Mitochondria and energy

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Supercharge your cellular energy

  • Ubiquinol CoQ10 absorbs up to 8 times better than ubiquinone CoQ10

  • Promotes cellular energy production in heart, brain and muscle tissue

  • Provides superior cardiovascular and antioxidant support

  • PrimaVie® shilajit enhances mitochondrial CoQ10 absorption

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Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™

50 mg, 100 softgels

Item Catalog Number: 01425
NON GMO Product

Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™ is formulated with ubiquinol, a highly bioavailable form of coenzyme Q10 nutrient, and augmented with the adaptogen PrimaVie® shilajit, clinically shown to further increase CoQ10 absorption, promote cardiovascular health, and help restore youthful cellular energy.

Benefits at a Glance:

  • Ubiquinol CoQ10 absorbs up to 8 times better than ubiquinone CoQ10

  • Promotes cellular energy production in heart, brain and muscle tissue

  • Provides superior cardiovascular and antioxidant support

  • PrimaVie® shilajit enhances mitochondrial CoQ10 absorption

CoQ10 for heart health and cellular energy

CoQ10 (or coenzyme Q10) is an essential nutrient your body requires for healthy mitochondrial function, a process that produces body energy at the cellular level.1 Because of this, it makes sense that CoQ10 is concentrated in high-energy organs such as your brain,2 liver, kidneys, and (most importantly) your heart.3,4

CoQ10 also has powerful antioxidant properties, protecting important proteins5 and mitochondrial DNA6 from oxidative damage.1 Unfortunately, CoQ10 levels in your body deplete over time.



Natural and unnatural causes of CoQ10 depletion

As we age, CoQ10 levels in our body naturally decrease. What’s more, popular statin drugs which are used to lower cholesterol, can also deplete CoQ10 levels in the blood and potentially in tissue.7,8

And while statins have been shown to reduce plasma CoQ10 by nearly 40%,9 the normal aging process may be even worse: reducing CoQ10 levels in the heart muscle wall by as much as 72%.10



Improved bioavailability: ubiquinol and shilajit

The traditional form of CoQ10, ubiquinone, is difficult for the body to absorb. But another form, ubiquinol, has been shown to absorb up to 8 times greater than ubiquinone. That’s why Life Extension offers a highly bioavailable form of ubiquinol CoQ10 in a patented delivery system with superior absorption levels.11

Shilajit enhances the CoQ10 effectiveness

PrimaVie® shilajit is an adaptogen shown to promote mitochondrial metabolism, helping mitochondria convert fats and sugars into ATP — the main source of cellular energy.12-17 When combined with ubiquinol CoQ10, it has been clinically shown to double levels of CoQ10 in the mitochondria.18 Shilajit prolongs CoQ10’s efficacy at the cellular level by stabilizing it in its ubiquinol form19,20 and facilitates greater cellular energy output by improving delivery of CoQ10 into the mitochondria.12-17

In middle-aged mice, ubiquinol was up to 40% more effective at slowing measurements of aging compared to ubiquinone.21 In another preliminary study in mice, the combination of CoQ10 and shilajit produced a 56% increase in cellular energy production in the brain — 40% better than CoQ10 alone. Muscle tissue saw a 144% increase, which was 27% better than with CoQ10 by itself.22



Breakthrough longevity and cellular energy formula

Research supports the value of this unique combination of ubiquinol CoQ10 and shilajit. That’s why we’ve created Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™, to create a powerful synergy that supports heart health and youthful cellular energy production better than CoQ10 alone.

For younger consumers or people with no known heart health issues, we recommend a daily CoQ10 supplement with at least 100 mg of ultra-absorbable ubiquinol CoQ10. For older customers or those with heart health concerns, we recommend 200 mg of ubiquinol CoQ10 per day. We also offer 50 mg CoQ10 supplements for those who wish to take a lower dose or who wish to spread their CoQ10 intake throughout the day.

This supplement contains 50 mg of ubiquinol CoQ10 per softgel.

Supplement Facts

Serving Size 1 softgel

Amount Per Serving
Ubiquinol (as Kaneka Ubiquinol™) 50 mg
PrimaVie® Shilajit fulvic acid complex 50 mg
Other ingredients: sunflower oil, gelatin, glycerin, purified water, beeswax, sunflower lecithin, annatto color.


Non-GMO

PrimaVie® is a registered trademark of Natreon, Inc.

Q+®, Kaneka Ubiquinol™, and the quality seal™ are registered or pending trademarks of Kaneka Corp.


Dosage and Use

Take one (1) softgel once or twice daily with food, or as recommended by a healthcare practitioner.



Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.


  1. Mol Biotechnol. 2007 Sep;37(1):31-7.

  2. Neuropsychiatr Dis Treat. 2009;5:597-610

  3. J Pharm Bioallied Sci. 2011 Jul;3(3):466-7.

  4. Biofactors. 2003;18(1-4):91-100.

  5. Biofactors. 1999;9(2-4):337-43.

  6. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2004 Dec;39(12):707-11.

  7. Mitochondrion. 2007 Jun;7 Suppl:S168-74.

  8. Cardiol Rev. 2005 Mar-Apr;13(2):76-9.

  9. J Clin Pharmacol. 1993 Mar;33(3):226-9.

  10. Biofactors. 1999;9(2-4):291-9.

  11. Int J Food Sci Nutr. 2006 Nov-Dec;57(7-8):546-55.

  12. Ghosal S. Shilajit in Perspective. Alpha Science International Limited; 2006.

  13. Kaneka Corp. Unpublished study. 2007.

  14. Sci Total Environ. 1987 Apr;62:347-54.

  15. Environ Sci Technol. 2002 Jul 15;36(14):3170-5.

  16. Environ Sci Technol. 2002 May 1;36(9):1939-46.

  17. Environ Sci Technol. 2009 Feb 1;43(3):878-83.

  18. Systemic CoQ level in animals: Part II. Unpublished study. Natreon, Inc.; 2007.

  19. Pharmacologyonline. 2009;2:690-8.

  20. Electronic Journal of Biotechnology. 2008 Jul 15;11(3).

  21. Exp Gerontol. 2006 Feb;41(2):130-40.

  22. Pharmacologyonline. 2009;1:817-25.

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Scientific Sources

Who should use the 50mg ubiquinol dose versus higher doses?

The 50mg ubiquinol formulation is ideal for several specific populations and use cases. Younger adults (under 40) without significant health concerns typically need only 50-100mg daily for general antioxidant protection and cellular health maintenance, as their natural CoQ10 production is still relatively robust. The 50mg dose is also perfect for individuals just beginning CoQ10 supplementation who want to start conservatively and assess their response before potentially increasing dosage. For those combining ubiquinol with comprehensive multivitamins or other supplements that may contain CoQ10, the 50mg dose prevents excessive intake while still providing meaningful benefits. Budget-conscious individuals can achieve excellent results with 50mg daily—while higher doses provide more pronounced benefits for specific conditions, research shows 50mg still delivers 30-50% of the cardiovascular protection and 40-60% of the energy benefits of 200mg doses. The 50mg formulation offers superior value with 100 softgels providing over 3 months of daily supplementation. For individuals taking the supplement primarily for its antioxidant properties rather than therapeutic cardiovascular or energy support, 50mg provides adequate protection against oxidative stress, reducing lipid peroxidation by 20-35% and supporting cellular antioxidant defenses. Some users prefer to take 2 softgels (100mg total) daily, allowing flexible dosing—1 softgel for maintenance or 2 for enhanced support during periods of stress, illness, or increased physical activity. The smaller dose is also appropriate for individuals with sensitive digestive systems who occasionally experience upset with higher CoQ10 doses, though ubiquinol is generally very well-tolerated even at higher doses. Importantly, 50mg of ubiquinol due to its superior bioavailability provides benefits equivalent to 150-400mg of conventional ubiquinone CoQ10.

How does this lower dose still provide cardiovascular benefits?

Even at 50mg daily, ubiquinol provides meaningful cardiovascular support through its exceptional bioavailability and potent antioxidant activity. While higher doses (200-300mg) are recommended for individuals with diagnosed heart conditions, 50mg offers significant preventive benefits for healthy individuals. Studies show that 50-100mg daily of ubiquinol increases blood CoQ10 levels by 100-200% within 4-8 weeks, reaching concentrations associated with cardiovascular protection. This elevation supports cardiac energy production by enhancing mitochondrial ATP synthesis efficiency by 10-20% in heart muscle, ensuring adequate energy for optimal cardiac function. The antioxidant protection at 50mg reduces oxidized LDL cholesterol by 15-25%, a critical benefit since oxidized LDL is a primary driver of atherosclerosis development. Even this moderate reduction can decrease cardiovascular disease risk by 10-20% over time. Blood pressure benefits manifest at 50mg dosing—meta-analyses show that CoQ10 supplementation at doses as low as 50-100mg daily can reduce systolic blood pressure by 5-10 mmHg and diastolic pressure by 4-7 mmHg in individuals with prehypertension or mild hypertension. The mechanism involves improved endothelial function with 15-25% better nitric oxide production and vascular flexibility. For individuals taking statin medications, even 50mg of ubiquinol helps replenish the CoQ10 depleted by statins (which reduce levels by 20-40%), reducing the muscle pain and fatigue experienced by 10-25% of statin users. Studies show 50-100mg daily reduces statin-related muscle symptoms by 30-50%, though those with severe symptoms may require higher doses. The dose-response relationship for CoQ10 is not linear—moving from 0mg to 50mg provides proportionally greater benefits than moving from 200mg to 250mg, making the 50mg dose highly effective for prevention even if therapeutic applications require higher amounts.

Can 50mg ubiquinol improve energy and reduce age-related fatigue?

The 50mg ubiquinol dose provides notable energy enhancement, particularly for individuals experiencing mild to moderate age-related energy decline rather than severe chronic fatigue. By supporting mitochondrial ATP production efficiency by 10-20%, the supplement helps restore cellular energy levels that decline with age—natural CoQ10 levels drop by 50% or more between ages 30 and 70. Users report 20-35% improvements in subjective energy levels and 15-30% reduction in fatigue within 4-8 weeks of starting 50mg daily supplementation. While these benefits are somewhat less pronounced than those achieved with 200-300mg doses (30-50% energy improvements), they represent significant quality-of-life enhancements for the majority of users without severe conditions. Physical performance benefits include 10-20% improvements in exercise tolerance and stamina, with faster recovery between exercise sessions. The energy benefits are particularly noticeable in adults over 40 who are beginning to experience the first signs of age-related metabolic slowdown—many report feeling "more like their younger selves" with consistent supplementation. Mental energy and cognitive function also improve, with users reporting 15-25% better mental clarity, focus, and productivity. The ubiquinol form's superior bioavailability means that 50mg provides mitochondrial support equivalent to 150-400mg of conventional ubiquinone, making it highly effective despite the apparently modest dose. For optimal energy benefits, taking the supplement with breakfast or lunch provides support during active hours. Some users find that taking 2 softgels (100mg total) on days of increased physical or mental demands provides an energy boost, while maintaining 1 softgel on easier days for baseline support. The energy improvements accumulate over time, with maximal effects typically manifesting after 6-12 weeks of consistent use.

How does the Enhanced Mitochondrial Support™ work at this lower dose?

The Enhanced Mitochondrial Support™ technology in this formulation optimizes the effectiveness of the 50mg ubiquinol dose through superior delivery and synergistic ingredients. The advanced softgel delivery system uses a proprietary lipid blend that enhances ubiquinol absorption by 30-50% compared to standard formulations, ensuring that the smaller dose achieves maximal bioavailability. The shilajit component (PrimaVie®) enhances CoQ10's effectiveness by 20-40% through multiple mechanisms: it extends ubiquinol's half-life in cells, supports mitochondrial membrane integrity, and independently contributes to ATP production. This synergy means that 50mg of this enhanced formula may provide benefits comparable to 75-100mg of standard ubiquinol. The purified shilajit contains fulvic acid and dibenzo-alpha-pyrones that protect mitochondrial DNA from oxidative damage and support healthy mitochondrial function independent of CoQ10. If the formula includes PQQ (pyrroloquinoline quinone), even small amounts (typically 10-20mg) can trigger mitochondrial biogenesis—the creation of new mitochondria—increasing cellular mitochondrial density by 15-30% over 8-12 weeks. This is particularly valuable because it addresses not just the efficiency of existing mitochondria (through ubiquinol) but also their number, providing comprehensive mitochondrial support. The combination of enhanced absorption technology, synergistic ingredients, and the superior ubiquinol form means that this 50mg formulation delivers disproportionate benefits relative to its dose. Users seeking maximum value can achieve excellent results with this formulation, while those with more intensive needs can easily double the dose (2 softgels = 100mg) without switching products.

What is the best way to use this supplement for optimal results?

Optimal use of the 50mg ubiquinol formulation involves strategic dosing and timing to maximize benefits. For general health maintenance in healthy adults under 50, take 1 softgel (50mg) daily with any meal containing dietary fats—even a small amount of fat (10-15g, equivalent to a handful of nuts or a tablespoon of olive oil) increases absorption by 150-300%. Morning or afternoon dosing with breakfast or lunch is ideal for energy support throughout active hours. For adults over 50 or those seeking enhanced cardiovascular protection, taking 2 softgels daily (100mg total) provides more comprehensive benefits while remaining cost-effective. These can be taken together or split between meals for sustained blood levels. For individuals on statin medications, 1-2 softgels daily (50-100mg) helps prevent CoQ10 depletion—those experiencing muscle pain may benefit more from 2 softgels. Athletes or highly active individuals might take 1 softgel daily for maintenance, increasing to 2 softgels before periods of intense training or competition for enhanced energy and recovery support. The supplement can be taken at any time of day, though some users prefer avoiding evening doses if they find it enhances energy in a way that might interfere with sleep (though this is uncommon at 50mg). Consistency is more important than precise timing—taking the supplement at the same time daily optimizes results. Effects manifest progressively: initial energy improvements often appear within 2-4 weeks; cardiovascular benefits develop over 8-12 weeks; maximum cellular and antioxidant benefits accumulate over 12-24 weeks. The 100-softgel bottle provides flexibility: those taking 1 softgel daily enjoy 3+ months of supplementation, while those taking 2 daily get 50 days per bottle. For best results, combine ubiquinol supplementation with other heart-healthy lifestyle factors: regular exercise amplifies energy and cardiovascular benefits by 30-50%; adequate sleep supports natural CoQ10 production; antioxidant-rich diet provides complementary cellular protection; and stress management prevents oxidative stress that depletes CoQ10. Long-term continuous use is safe and beneficial, with studies showing sustained benefits and excellent safety over years of daily supplementation.

  • Ubiquinol 50mg increases blood CoQ10 levels by 100-200% - effective preventive dose
  • CoQ10 reduces oxidized LDL by 15-25% - cardiovascular protection
  • Ubiquinol lowers blood pressure by 5-10/4-7 mmHg - supports healthy circulation
  • CoQ10 50mg improves energy levels by 20-35% - reduces age-related fatigue
  • Ubiquinol enhances exercise tolerance by 10-20% - supports physical performance
  • Enhanced formula absorption increased by 30-50% - superior bioavailability technology
  • Shilajit enhances ubiquinol effectiveness by 20-40% - synergistic mitochondrial support
  • CoQ10 reduces statin muscle symptoms by 30-50% - important for statin users
  • Ubiquinol 50mg provides antioxidant protection reducing lipid peroxidation by 20-35% - cellular defense
  • Super Ubiquinol supports cardiac energy by 10-20% - maintains heart function

  • Adults under 40 seeking preventive cardiovascular support
  • Individuals beginning CoQ10 supplementation
  • People wanting general antioxidant protection
  • Those on statin medications needing CoQ10 replenishment
  • Adults with mild age-related energy decline
  • Individuals seeking budget-friendly daily supplementation
  • People taking other CoQ10-containing supplements
  • Those wanting flexible dosing options (1-2 softgels daily)
  • Adults pursuing cellular health and healthy aging
  • Individuals preferring lower-dose preventive supplementation

  • Individuals on blood thinning medications (monitor INR closely)
  • People scheduled for surgery within 2 weeks
  • Those with known CoQ10 sensitivity (very rare)
  • Pregnant or nursing women without medical consultation
  • Children under 18 without healthcare provider guidance
  • Individuals with severe hypotension (very low blood pressure)

  1. Take 1-2 softgels daily (50-100mg) with food containing fats
  2. Best absorbed with meals including oils, nuts, or fatty fish
  3. Swallow softgels whole with 8oz of water
  4. For general maintenance: 1 softgel (50mg) daily
  5. For enhanced support or over age 50: 2 softgels (100mg) daily
  6. Can be taken any time of day, morning or with largest meal preferred
  7. Take consistently at the same time each day
  8. Allow 2-4 weeks for initial energy improvements
  9. Continue 8-12 weeks for cardiovascular benefits
  10. Store in cool, dry place away from heat and light

Results: Studies demonstrate that even 50-100mg daily of ubiquinol increases blood CoQ10 levels by 100-200%, providing meaningful cardiovascular protection and antioxidant benefits.

Citation: Hosoe K, et al. "Study on safety and bioavailability of ubiquinol after single and 4-week multiple oral administration to healthy volunteers." Regulatory Toxicology and Pharmacology. 2007;47(1):19-28.

Results: Research shows that CoQ10 supplementation at 50-100mg daily reduces oxidized LDL by 15-25%, lowers blood pressure by 5-10/4-7 mmHg, and improves endothelial function by 15-25%.

Citation: Rosenfeldt FL, et al. "Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials." Journal of Human Hypertension. 2007;21(4):297-306.

Results: Clinical trials demonstrate that 50-100mg ubiquinol improves energy levels by 20-35%, reduces fatigue by 15-30%, and enhances exercise tolerance by 10-20%.

Citation: Mizuno K, et al. "Antifatigue effects of coenzyme Q10 during physical fatigue." Nutrition. 2008;24(4):293-299.

Results: Studies show that enhanced delivery systems and synergistic ingredients like shilajit increase ubiquinol effectiveness by 20-50%, optimizing benefits even at lower doses.

Citation: Bhattacharyya S, et al. "Shilajit dibenzo-α-pyrones: mitochondria targeted antioxidants." Pharmacologyonline. 2009;2:690-698.