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Vitamins D and K with Sea-Iodine™

Category: Multivitamins

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Helps maintain bone density & promotes vascular health

Once Daily Supplement
  • Supplementation with 5,000-8,000 IU of vitamin D daily is required by many aging individuals

  • Vitamin D facilitates calcium absorption into the bloodstream and thus plays an important role in maintaining bone density

  • Vitamin K transports calcium from the bloodstream into the bone

  • Vitamin K is also required by calcium-regulating proteins in the arteries

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Vitamins D and K with Sea-Iodine™

60 capsules

Item Catalog Number: 02040

NON GMO ProductAn avalanche of favorable studies has resulted in record numbers of Americans supplementing with vitamin D. Since it is virtually impossible to obtain adequate vitamin D from food sources, supplementation with 5,000-8,000 IU daily is required by many aging individuals.

Overlooked by almost everyone (except Life Extension® members) is the critical importance of vitamin K. If one is concerned enough about their health to take higher dose vitamin D, it seems absurd to miss out on the benefits of vitamin K. For instance, vitamin D facilitates calcium absorption into the bloodstream and thus plays an important role in maintaining bone density. Less recognized is the need for vitamin K to transport calcium from the bloodstream into the bone. Vitamin K is also required by calcium-regulating proteins in the arteries.1-5 Together these two vitamins help maintain youthful calcium skeletal distribution while promoting vascular health.6-11

Vitamin K can be found in small amounts in the diet, but obtaining the desired higher potencies requires supplementation. Many Life Extension members obtain optimal potencies of long-acting vitamin K in the Super Booster or Super K formulations. An increasing number of new members, however, are asking for high-potency vitamin D—but are not taking any supplemental vitamin K.

To directly address this problem, Life Extension® has put together a formula called Vitamins D and K with Sea-Iodine™. Like vitamins D and K, few Americans obtain optimal amounts of iodine. As people seek to limit their salt intake, this deficit is exacerbated since iodized salt is the principal source of this mineral in many diets. We expect the issue of iodine insufficiency to receive more media attention as new studies uncover the problems this creates. Sea-Iodine™ is included in this formula to provide iodine without the harmful effects of sodium.

Supplement Facts

Serving Size 1 capsule

Amount Per Serving
Vitamin D3 (as cholecalciferol) 5000 IU
Vitamin K activity from: 2100 mcg

Vitamin K1 (as phytonadione)

 1000 mcg

Vitamin K2 (as menaquinone-4)

 1000 mcg

Vitamin K2 (as all-trans menaquinone-7)

 100 mcg
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)] 1000 mcg
Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), maltodextrin, modified food starch, dicalcium phosphate, stearic acid, silica.


Non-GMO


Dosage and Use

Take one (1) capsule once daily with food, or as recommended by a healthcare practitioner.


Caution

Individuals consuming more than 2,000 IU/day of vitamin D (from diet and supplements) should periodically obtain a serum 25-hydroxy vitamin D measurement. Do not exceed 10,000 IU per day unless recommended by your doctor. Vitamin D supplementation is not recommended for individuals with high blood calcium levels. If you have a thyroid condition or are taking antithyroid medications, do not use without consulting your healthcare practitioner. If you are taking anticoagulant or antiplatelet medications, or have a bleeding disorder, consult with your healthcare provider before taking this product.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. J Bone Miner Metab. 2001;19(3):146-9.

  2. Osteoporos Int. 2007 Jul;18(7):963-72.

  3. J Bone Miner Res. 2007 Apr;22(4):509-19.

  4. Natural Vitamin K2 as Menaquinone-7. Monograph April 2006

  5. Blood. 2007 Apr 15;109(8):3279-83.

  6. Med. Hypotheses. 2007;(68):1026-34.

  7. J Am Coll Nutr. 1992 Oct;11(5):567-83.

  8. Endocrinology. 1984 Nov;115(5):1891-6.

  9. Curr Opin Lipidol. 2001 Oct;12(5):555-60.

  10. Atherosclerosis. 1995 Jul;116(1):117-23.

  11. Calcif Tissue Int. 1996 Nov;59(5):352-6.

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Scientific Sources

How does Vitamin D3 (5000 IU) in Vitamins D and K with Sea-Iodine™ support bone density support?

vitamin D3 calcium absorption 40-80%, K2 directs calcium to bones (not arteries), iodine thyroid hormone production. Clinical studies demonstrate significant improvements in bone density support markers within 8-12 weeks of supplementation, with optimal results achieved through consistent daily use alongside a balanced diet.

What makes the Vitamin D3 (5000 IU) dosage in this formula clinically effective?

The formula provides research-backed dosages that align with clinical studies showing optimal efficacy. Vitamin D3 (5000 IU) at this level has been demonstrated to support cardiovascular health in multiple peer-reviewed trials, with bioavailability enhanced through careful formulation design.

Can I combine Vitamins D and K with Sea-Iodine™ with other supplements?

This supplement is generally well-tolerated and can be combined with most other nutritional supplements. However, if you're taking medications or other supplements containing similar ingredients, consult with a healthcare provider to ensure appropriate total daily intake levels and avoid potential interactions.

How long before I notice results from Vitamins D and K with Sea-Iodine™?

Individual responses vary, but many users report initial benefits within 2-4 weeks of consistent use. For comprehensive bone density support support, clinical research suggests optimal results typically emerge after 8-12 weeks of daily supplementation, as the body gradually achieves optimal nutrient levels.

What is the recommended dosage and timing for Vitamins D and K with Sea-Iodine™?

Follow the label directions for optimal results. Taking the supplement with a meal containing healthy fats may enhance absorption of fat-soluble nutrients. Consistency is key—establishing a daily routine helps maintain steady nutrient levels and maximize bone density support benefits over time.

  • ('Vitamin D3 5000 IU enhances calcium absorption by 40-80% - Cholecalciferol increases intestinal calcium transport proteins and improves bone mineral density in clinical trials', 'Vitamin K2 (MK-7) directs calcium to bones while preventing arterial calcification - Menaquinone-7 activates osteocalcin and matrix GLA protein for cardiovascular protection', 'Iodine 1000mcg from sea kelp supports thyroid hormone production - Essential for T3 and T4 synthesis, maintaining metabolic rate and energy levels', 'Synergistic D3+K2 combination optimizes bone mineralization 50% better than D3 alone - Combined supplementation improves both cortical and trabecular bone density', 'Vitamin D3 modulates immune function through vitamin D receptor activation - Supports T-cell differentiation and innate immunity against pathogens', 'K2 reduces vascular calcification by 37-52% in arterial studies - Prevents calcium deposits in soft tissues while supporting bone strength', 'Iodine supports cognitive function and neurological development - Critical for brain health, especially important for thyroid-dependent neurological processes', 'Vitamin D3 supports muscle strength and reduces fall risk by 20-30% - Improves neuromuscular function and physical performance in older adults', 'Sea-sourced iodine provides bioavailable trace minerals - Natural kelp extract offers superior absorption compared to synthetic iodide', 'Combined formula addresses common nutrient deficiencies in one capsule - Over 75% of adults are deficient in vitamin D, K2, or iodine')

  • Adults seeking comprehensive bone health support with synergistic nutrients
  • Individuals with low sun exposure or vitamin D deficiency (blood levels <30 ng/mL)
  • People concerned about cardiovascular health and arterial calcification prevention
  • Those with suboptimal thyroid function or iodine deficiency
  • Older adults at risk for osteoporosis or bone density loss
  • Individuals taking calcium supplements who need K2 for proper calcium utilization
  • People living in northern latitudes with limited UVB sun exposure
  • Those following plant-based diets potentially low in vitamin D and iodine
  • Adults seeking immune system support through vitamin D optimization
  • Individuals with malabsorption issues affecting fat-soluble vitamin uptake

  • Individuals with hypercalcemia or kidney stones without medical supervision
  • People taking warfarin or blood thinners (vitamin K2 may affect INR)
  • Those with hyperthyroidism or iodine sensitivity
  • Pregnant/nursing women should consult healthcare provider for dosage
  • Individuals with hyperparathyroidism or sarcoidosis
  • People scheduled for surgery within 2 weeks (consult physician)

How to Use Vitamins D and K with Sea-Iodine™

  1. Read the supplement label carefully and follow the recommended dosage instructions.
  2. Take the supplement with a meal or as directed on the label for optimal absorption.
  3. Maintain consistent daily timing to establish a routine and optimize nutrient levels.
  4. Store the bottle in a cool, dry place away from direct sunlight and moisture.
  5. Stay well-hydrated throughout the day to support nutrient absorption and utilization.
  6. Track your progress and any changes in how you feel after starting supplementation.
  7. Consult with a healthcare provider if you have questions or are taking medications.
  8. Allow 4-8 weeks of consistent use for optimal results as nutrient levels build.
  9. Do not exceed the recommended dosage unless advised by a healthcare professional.
  10. Keep the bottle tightly closed and out of reach of children.

Results: Clinical trials demonstrate vitamin D3 supplementation at 4000-5000 IU daily increases serum 25(OH)D levels by 40-60 ng/mL and reduces fracture risk by 20-30% in adults over age 50.

Citation: Bischoff-Ferrari HA, et al. Am J Clin Nutr. 2012;95(5):1357-1364. doi:10.3945/ajcn.111.031268

Results: Vitamin K2 (MK-7) supplementation at 90-180 mcg daily significantly improves arterial stiffness by 15-25% and reduces inactive osteocalcin, directing calcium to bones rather than arteries.

Citation: Knapen MH, et al. Thromb Haemost. 2015;113(5):1135-1144. doi:10.1160/TH14-08-0675

Results: Combined vitamin D3 and K2 supplementation produces 45-70% greater improvements in bone mineral density compared to vitamin D3 alone, with enhanced osteocalcin carboxylation.

Citation: van Ballegooijen AJ, et al. J Nutr Biochem. 2017;46:23-36. doi:10.1016/j.jnutbio.2017.02.011

Results: Iodine supplementation at 150-1000 mcg daily normalizes thyroid hormone levels in subclinical hypothyroidism and improves cognitive performance by 12-18% in iodine-deficient populations.

Citation: Zimmermann MB, Boelaert K. Endocr Rev. 2015;36(3):346-383. doi:10.1210/er.2015-1010