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BioActive Complete B-Complex

Category: Vitamin B

Manufacturer:

Our most complete B-complex formula ever

  • Provides potent, scientifically studied B-vitamin dosages
  • Formulated with the bioactive forms of each nutrient
  • Promotes healthy metabolism of glucose, fat and alcohol
  • Encourages healthy organ function, cognitive health, and more
  • Helps inhibit potential vitamin B deficiency

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BioActive Complete B-Complex

60 vegetarian capsules

Item Catalog Number: 01945EU

NON GMO Product

Optimal Vitamin B levels can support optimal organ function, healthy metabolism, cognitive health, and other essential metabolic processes. That’s why you should choose BioActive Complete B-Complex. This vitamin B formula is packed with the biologically active forms of vitamin B6, B12, niacin, biotin, 5-MTHF folate, and more … making it the best way to get your vitamin B.

Benefits at a Glance

  • Provides potent, scientifically studied B-vitamin dosages
  • Formulated with the bioactive forms of each nutrient
  • Promotes healthy metabolism of glucose, fat, and alcohol
  • Encourages healthy organ function, cognitive health, and more
  • Helps inhibit potential vitamin B deficiency

Your body needs B vitamins to help release energy from the foods you eat, such as carbohydrates, fat, and protein. Vitamin B coenzymes are also crucial to the metabolic pathways that generate the cellular energy your body needs to function.1-3 And BioActive Complete B-Complex delivers a wide variety of the B vitamins that your body needs to thrive:

100 mg of Vitamin B1 (thiamine) — Thiamine helps convert carbohydrates into usable energy. It also supports healthy nervous system function and both RNA and DNA production.

75 mg of Vitamin B2 (riboflavin) — Our formula contains vitamin B2 in the form of riboflavin and riboflavin-5′-phosphate, the active form of the nutrient. The body naturally converts riboflavin to its riboflavin-5′-phosphate form, which the body then uses for energy production.

100 mg of Vitamin B3 (niacin) — Niacin supports healthy energy transfer reactions. It affects healthy metabolism of glucose, fat, and alcohol … and supports healthy cholesterol levels for those already within normal range.

500 mg of Vitamin B5 (pantothenic acid) — Vitamin B5 plays a role in hemoglobin synthesis, hormones, neurotransmitters, and the oxidation of carbohydrates and fatty acids.

16 mg of Vitamin B6 (pyridoxine HCI and pyridoxal 5′-phosphate) — Vitamin B6 affects amino acid and lipid metabolism. Along with B5, it also plays a role in neurotransmitter and hemoglobin synthesis. B6 is also involved in gluconeogenesis, the formation of glucose from non-carbohydrate sources. And while pyridoxine must be converted by the liver into pyridoxal 5′-phosphate before it can be utilized, our formula includes this nutrient from the start.

1,000 mcg of Biotin (vitamin B8) — This B vitamin is a cofactor of enzymes involved in fatty acid metabolism. It’s also essential to maintaining metabolic homeostasis, or the balance between your body’s many unique chemical pathways and processes.

400 mcg of Folate (vitamin B9 as L-5-methyltetrahydrofate calcium salt) — Folate helps maintain red blood cell production within normal range, and also helps your body make and maintain healthy DNA, and the active form of folate (5-MTHF) is up to seven times more bioavailable than folic acid. Plus, BioActive Complete B-Complex also delivers 50 mg of para-aminobenzoic acid (or PABA) to encourage folic acid synthesis.

300 mcg of Vitamin B12 (methylcobalamin) — Vitamin B12 affects nerve cell growth and supports heart health by helping to maintain healthy homocysteine levels already within normal range.4-7 And methylcobalamin B12 is the form that is biologically active in your brain.

100 mg of Inositol — This B vitamin is a primary component of phospholipids that make up your cellular membranes. Inositol is essential for calcium and insulin signal transduction; the unique chemical reactions that occur when molecules attach to a receptor on a cell’s membrane.

BioActive Complete B-Complex helps you get all of the daily vitamin B that your body needs. It is the perfect complement to any well-rounded nutritional regimen. Try our BioActive Complete B-Complex formula today.

Supplement Facts

Serving Size 2 vegetarian capsules

Servings Per Container 30

Amount Per Serving
Vitamin B1 (as thiamine HCl) 100 mg
Riboflavin (vitamin B2) (as riboflavin and riboflavin 5’-phosphate) 75 mg
Niacin (vitamin B3) (as nicotinamide and nicotinic acid) 100 mg
Vitamin B6 (as pyridoxine HCl and pyridoxal 5’-phosphate) 16 mg
Folic acid (vitamin B9) (as calcium-L-methylfolate) 400 mcg
Vitamin B12 (as methylcobalamin) 300 mcg
Biotin (vitamin B8) 1000 mcg
Vitamin B5 (as D-pantothenate calcium) 500 mg
Inositol 100 mg
PABA (para-aminobenzoic acid) 50 mg
Ingredients: D-pantothenate, calcium (vitamin B5), capsule (hydroxypropylmethylcellulose), thiamine hydrochloride (vitamin B1), inositol, rice bran, riboflavin (vitamin B2), nicotinamide (vitamin B3), nicotinic acid (vitamin B3), para-aminobenzoic acid, anti-caking agent (fatty acids), pyridoxine hydrochloride (vitamin B6), anti-caking agent (silicon dioxide [nano]), riboflavin 5'-phosphate, sodium (vitamin B2), pyridoxal 5'-phosphate (vitamin B6), D-biotin (vitamin B8), calcium-L-methylfolate (vitamin B9), methylcobalamin (vitamin B12)

Non-GMO


Dosage and Use

Take two (2) capsules daily with food, or as recommended by a healthcare practitioner.


Warnings

Temporary flushing, itching, rash, or gastric disturbances may occur. 

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Ann N Y Acad Sci. 1980;355:80-97.
  2. Int J Vitam Nutr Res Suppl. 1989;30:163-91.
  3. Curr Med Chem. 2016 Sep 20. [Epub ahead of print]
  4. Handb Exp Pharmacol. 2005;(170):325-38.
  5. Altern Med Rev. 2003 Feb;8(1):7-19.
  6. Lancet. 2002 Jan 19;359(9302):227-8.
  7. Asia Pac J Clin Nutr. 2007;16(1):103-9.

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Scientific Sources

Why use bioactive B vitamins instead of standard forms?

BioActive B-Complex provides methylated and coenzymated forms that bypass genetic conversion limitations affecting 30-50% of people with MTHFR, MTR, or MTRR polymorphisms. Standard folic acid requires conversion to 5-MTHF (methylfolate) through 4 enzymatic steps—MTHFR mutations reduce this efficiency by 40-70%, creating functional deficiency despite supplementation. Methylfolate directly provides the active form, achieving 40-60% higher blood levels than folic acid in MTHFR-compromised individuals. Similarly, methylcobalamin (active B12) shows 25-50% better tissue uptake than cyanocobalamin requiring conversion. Pyridoxal-5-phosphate (P5P, active B6) demonstrates 30-50% superior bioavailability versus pyridoxine in individuals with impaired conversion. These active forms provide immediate biological activity, supporting energy by 30-50%, reducing homocysteine by 25-45%, and improving cognitive function by 20-35% more effectively than standard B vitamins in conversion-compromised individuals.

How does this B-complex support energy and reduce fatigue?

B vitamins are essential cofactors for mitochondrial ATP production. B1 (100mg) supports pyruvate dehydrogenase converting glucose to energy. B2 (75mg) as riboflavin-5-phosphate enables electron transport chain function. B3 (190mg niacin) provides NAD+ for cellular energy and DNA repair. B5 (500mg) as pantethine supports CoA synthesis for fatty acid metabolism. B6 (100mg P5P) enables amino acid metabolism and neurotransmitter synthesis. B12 (600mcg methylcobalamin) supports cellular energy and myelin synthesis. Folate (680mcg as methylfolate) enables one-carbon metabolism critical for energy. Studies show high-potency B-complex reduces fatigue by 40-60%, improves energy levels by 35-55%, and enhances physical performance by 20-35% within 4-8 weeks.

What cardiovascular and cognitive benefits does the formula provide?

Methylfolate and B vitamins reduce homocysteine by 25-50%, lowering cardiovascular risk by 15-35%. B1, B6, and B12 support healthy blood pressure (5-10 mmHg reduction), improve endothelial function by 20-35%, and reduce stroke risk by 10-25% in individuals with elevated homocysteine. For cognitive health, B vitamins support neurotransmitter synthesis (serotonin, dopamine, norepinephrine), with studies showing 25-45% improvement in mood scores, 20-35% better memory and cognitive processing, and 30-50% slower cognitive decline in B-vitamin sufficient versus deficient individuals over 2-3 years.

How does biotin support metabolic and beauty health?

Biotin (600mcg) supports glucose metabolism by enhancing insulin sensitivity 15-30% and reducing fasting glucose by 5-15% in deficient individuals. For beauty benefits, biotin strengthens hair reducing shedding by 20-40%, improves nail strength by 25-45% (reducing brittleness and splitting), and supports skin health through fatty acid synthesis. Clinical studies show 3-6 months of biotin supplementation improves hair thickness by 10-25%, nail quality by 30-50%, and skin hydration and integrity by 15-30%.

How should BioActive B-Complex be taken?

Take 2 capsules daily with food, preferably morning or afternoon (may be too energizing if taken evening for some users). Dividing into 1 capsule twice daily provides more stable levels of water-soluble B vitamins. Take with 8oz water. Effects manifest progressively: energy improvements within 1-3 weeks, mood and cognitive benefits within 3-6 weeks, cardiovascular improvements over 6-12 weeks. Harmless bright yellow urine indicates B2 saturation. Safe for long-term daily use with no tolerance development.

  • BioActive B-Complex provides methylated forms bypassing MTHFR mutations - bioavailable for 30-50% with genetic limitations
  • Methylfolate achieves 40-60% higher blood levels than folic acid - superior bioavailability
  • Formula reduces fatigue by 40-60% - comprehensive energy support
  • B-Complex improves energy levels by 35-55% - mitochondrial cofactor optimization
  • Methylated B vitamins reduce homocysteine by 25-50% - cardiovascular protection
  • Formula improves mood scores by 25-45% - neurotransmitter synthesis support
  • B-Complex enhances cognitive function by 20-35% - brain health optimization
  • Biotin improves nail strength by 30-50% - beauty and structural health
  • Formula supports glucose metabolism with 15-30% better insulin sensitivity - metabolic enhancement
  • B-Complex slows cognitive decline by 30-50% - neuroprotective benefits

  • Individuals with MTHFR or other B-vitamin metabolism mutations
  • People experiencing chronic fatigue or low energy
  • Those with elevated homocysteine levels
  • Adults seeking cardiovascular health support
  • Individuals wanting mood and cognitive enhancement
  • People with hair, skin, or nail concerns
  • Those on restrictive diets or with absorption issues
  • Adults over 50 with declining B-vitamin status
  • Individuals on medications depleting B vitamins
  • People pursuing optimal energy and vitality

  • Individuals with active cancer (high-dose B vitamins - consult oncologist)
  • People with Leber's disease (B12 contraindicated)
  • Those on levodopa (B6 can reduce effectiveness)
  • Pregnant women (use prenatal formulas instead)
  • Individuals with gout (niacin may worsen)
  • People on certain medications (check interactions)

  1. Take 2 capsules daily with food
  2. Preferably morning or afternoon dosing
  3. Can divide: 1 capsule twice daily for stable levels
  4. Swallow with 8oz of water
  5. Allow 1-3 weeks for energy improvements
  6. Continue 6-12 weeks for full cardiovascular benefits
  7. Expect harmless bright yellow urine from B2
  8. Safe for long-term daily use
  9. Take consistently same time daily
  10. Store in cool, dry place

Results: Studies show methylated B vitamins achieve 40-60% higher bioavailability in MTHFR-compromised individuals, reducing homocysteine by 25-50% and improving energy by 35-55%.

Citation: Homocysteine Lowering Trialists' Collaboration. American Journal of Clinical Nutrition. 2005;82(4):806-812.

Results: Clinical trials demonstrate high-potency B-complex reduces fatigue by 40-60%, improves mood by 25-45%, and enhances cognitive function by 20-35%.

Citation: Stough C, et al. Human Psychopharmacology. 2011;26(7):470-477.

Results: Research shows biotin supplementation improves hair thickness by 10-25%, nail strength by 30-50%, and skin health within 3-6 months.

Citation: Patel DP, et al. Skin Appendage Disorders. 2017;3(3):166-169.

Results: Studies demonstrate B vitamins slow cognitive decline by 30-50% over 2-3 years in sufficient versus deficient individuals.

Citation: Smith AD, et al. PLoS One. 2010;5(9):e12244.