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Vitamin B12 500 mcg EU

Category: Vitamin B

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Vitamin B12 support for brain and heart health

  • Support nervous system function, brain health, and cognition
  • Promote heart health by contributing to healthy homocysteine levels
  • Provide the bioactive B12 form methylcobalamin

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Vitamin B12

500 mcg, 100 lozenges

Item Catalog Number: 00361EU

NON GMO ProductVitamin B12 is present in foods of animal origin, including dairy products and eggs. Thus, vegetarians are more susceptible to a dietary deficiency of this important nutrient.1 Likewise, vitamin B12 serum concentrations are reported to be significantly lower in elderly population groups compared to younger groups.2-5
Benefits at a Glance:
  • Support nervous system function, brain health, and cognition
  • Promote heart health by contributing to healthy homocysteine levels
  • Provide the bioactive B12 form methylcobalamin

It is estimated that 10% to 30% of individuals over the age of 50 have low stomach acid secretion6-7 which results in decreased bioavailability of vitamin B12 from food. To overcome food-bound vitamin B12 malabsorption problems, the Institute of Medicine recommends that vitamin B12-fortified foods (such as fortified ready-to-eat breakfast cereals) or supplements containing vitamin B12 be used to meet much of the requirement.8

Vitamin B12, or cobalamin, works synergistically with vitamin B6 and folate to regenerate (methylate) the amino acid methionine, which helps to maintain already healthy homocysteine levels within normal range, which is important for heart health.9-12

Supplement Facts

Serving Size 1 lozenge

Amount Per Serving
Vitamin B12 (as methylcobalamin) 500 mcg
Other ingredients: mannitol, sorbitol, microcrystalline cellulose, vegetable stearate, croscarmellose sodium, natural strawberry flavor.



Non-GMO


Dosage and Use

Take one (1) lozenge one to four times daily with or without food, or as recommended by a healthcare practitioner.

Place lozenge in mouth and allow to dissolve, then swallow.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Exp Biol Med (Maywood). 2007 Nov;232(10):1266-74.

  2. Am J Clin Nutr. 2009 Feb;89(2):693S-6S.

  3. Prev Med. 2004 Dec;39(6):1256-66.

  4. Am J Clin Nutr. 1999;70:904-910.

  5. Am J Clin Nutr. 2008 Aug;88(2):348-55.

  6. JAMA. 1997 Aug 27;278(8):659-62.

  7. J Am Geriatr Soc. 1986 Nov;34(11):800-6.

  8. Epidemiology. 2007 May;18(3):367-8.

  9. Lancet. 2002 Jan 19;359(9302):227-8.

  10. Asia Pac J Clin Nutr. 2007;16(1):103-9.

  11. Handb Exp Pharmacol. 2005;(170):325-38.

  12. Altern Med Rev. 2003 Feb;8(1):7-19.

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Scientific Sources

What is Vitamin B12 and why is it essential for health?

Vitamin B12, also called cobalamin, is a water-soluble vitamin essential for numerous bodily functions. It plays critical roles in red blood cell formation, DNA synthesis, neurological function, and energy metabolism. B12 is unique among vitamins because it contains cobalt and is required for proper functioning of all cells, particularly affecting DNA synthesis and regulation, fatty acid synthesis, and energy production. The body cannot produce B12, so it must be obtained from diet or supplements. B12 deficiency can lead to anemia, neurological problems, fatigue, and cognitive issues, making adequate intake crucial for overall health and wellbeing.

Who is at risk for vitamin B12 deficiency?

Several groups face increased B12 deficiency risk. Vegetarians and especially vegans often lack adequate B12 since it's naturally found primarily in animal products. Adults over 50 frequently have reduced stomach acid production, impairing B12 absorption from food. People taking proton pump inhibitors or metformin for extended periods may have reduced B12 absorption. Individuals with digestive disorders like Crohn's disease, celiac disease, or those who've had gastric surgery often cannot absorb B12 properly. Those with pernicious anemia lack intrinsic factor needed for B12 absorption. Pregnant and nursing women have increased B12 requirements. These groups should consider B12 supplementation and regular monitoring of B12 levels.

What are the symptoms of vitamin B12 deficiency?

B12 deficiency symptoms can develop gradually and vary in severity. Common symptoms include persistent fatigue and weakness, shortness of breath, pale or yellowish skin, and smooth tongue. Neurological symptoms may include numbness or tingling in hands and feet, balance problems, depression, confusion, and memory difficulties. Some people experience mood changes, irritability, or difficulty concentrating. In severe cases, B12 deficiency can cause megaloblastic anemia, characterized by abnormally large red blood cells. Long-term deficiency may lead to irreversible nerve damage. Because symptoms can be subtle initially and overlap with other conditions, anyone experiencing these symptoms should have B12 levels tested, especially if they're in a high-risk group.

What are the benefits of vitamin B12 supplementation?

B12 supplementation provides numerous health benefits, particularly for those with deficiency or at risk. It supports energy production at the cellular level, helping reduce fatigue and improve physical performance. B12 is essential for healthy nervous system function, supporting nerve health and cognitive function including memory and concentration. It plays crucial roles in red blood cell formation, preventing anemia and supporting oxygen delivery throughout the body. B12 supports cardiovascular health by helping maintain healthy homocysteine levels. The vitamin supports mood regulation and may help maintain emotional wellbeing. B12 also supports DNA synthesis, cell division, and overall cellular health, making it fundamental for maintaining optimal health across all body systems.

How should I take Vitamin B12 500 mcg for best results?

For optimal absorption, take B12 supplements on an empty stomach if possible, as food can interfere with absorption. However, if you experience stomach upset, taking with food is acceptable. The 500 mcg dose is suitable for maintenance and mild deficiency. For sublingual or dissolving tablets, allow them to dissolve completely under the tongue for enhanced absorption directly into the bloodstream, bypassing digestive processes. Take B12 consistently at the same time each day, preferably in the morning as it supports energy production. If you have severe deficiency, your healthcare provider may recommend higher doses initially. B12 is water-soluble, so excess is excreted, making it very safe. Combine with other B vitamins for comprehensive B-complex support and optimal metabolic function.

  • Vitamin B12 essential for red blood cell formation preventing anemia and supporting oxygen delivery - blood health
  • B12 supports healthy nervous system function and nerve health throughout entire body - neurological support
  • Helps maintain cognitive function memory and mental clarity with vitamin B12 - brain support
  • Vitamin B12 supports cellular energy production reducing fatigue and boosting vitality - energy support
  • B12 plays critical role in DNA synthesis and healthy cell division processes - cellular health
  • Supports cardiovascular health with B12 helping maintain healthy homocysteine levels - heart support
  • Vitamin B12 supports mood regulation and emotional wellbeing naturally - mood support
  • Provides 500 mcg B12 suitable for maintenance and supplementation needs - effective dose
  • Essential for vegetarians vegans and those over 50 with vitamin B12 needs - at-risk groups
  • Water-soluble B12 vitamin with excellent safety profile for daily use - safe supplementation

  • Vegetarians and vegans who may not get adequate vitamin B12 from plant-based diets
  • Adults over 50 with reduced stomach acid production affecting B12 absorption from food
  • People taking medications like PPIs or metformin that interfere with B12 absorption
  • Individuals experiencing fatigue weakness or cognitive concerns potentially related to deficiency
  • Those with digestive disorders or previous gastric surgery affecting nutrient absorption

  • People with Leber disease rare hereditary eye condition should avoid B12 supplementation
  • Those allergic to cobalt or cobalamin should not take vitamin B12 supplements
  • Individuals with certain blood disorders should consult hematologist before supplementing
  • People receiving B12 injections should coordinate oral supplementation with doctor
  • Those with kidney disease should verify appropriate B12 dosing with physician

  1. Take 500 mcg daily preferably on empty stomach for optimal B12 absorption
  2. If using sublingual form allow tablet to dissolve completely under tongue
  3. Take in morning as B12 supports energy production and may affect sleep if taken late
  4. Maintain consistent daily use as B12 levels build gradually with regular supplementation
  5. If stomach upset occurs take with food though absorption may be slightly reduced
  6. Combine with other B vitamins for comprehensive B-complex metabolic support
  7. Allow 4-8 weeks of consistent use for noticeable energy and cognitive improvements
  8. Store in cool dry place away from light to preserve vitamin B12 potency

Results: Clinical studies demonstrate vitamin B12 supplementation effectively corrects deficiency and improves associated symptoms including fatigue, weakness, and neurological issues, with most patients showing significant improvements within 6-12 weeks of adequate supplementation.

Citation: Stabler SP. N Engl J Med. 2013 Jan;368(2):149-60.

Results: Research shows B12 plays essential role in homocysteine metabolism, with supplementation significantly reducing elevated homocysteine levels—an independent cardiovascular risk factor—by 20-30% in individuals with elevated levels or deficiency.

Citation: Selhub J, et al. JAMA. 1993 Dec;270(22):2693-8.

Results: Studies indicate B12 deficiency affects cognitive function, with supplementation improving memory, concentration, and mental clarity in deficient individuals, particularly beneficial for older adults with age-related cognitive decline.

Citation: Smith AD, et al. PLoS One. 2010 Sep;5(9):e12244.

Results: Clinical trials confirm oral B12 supplementation is effective even in individuals with absorption issues, with high oral doses (500-1000 mcg daily) achieving adequate B12 status comparable to injections in most cases.

Citation: Kuzminski AM, et al. Blood. 1998 Jan;92(4):1191-8.