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Vitamins D and K

Category: Multivitamins

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Supports healthy bones & cardiovascular health

  • Supplementation with 5,000-8,000 IU of vitamin D daily is required by many aging individuals
  • Vitamin D facilitates calcium absorption into the bloodstream and thus plays an important role in maintaining bone density
  • Vitamin K transports calcium from the bloodstream into the bone
  • Vitamin K is also required by calcium-regulating proteins in the arteries

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Vitamins D and K

60 capsules

Item Catalog Number: 02040EU

An avalanche of favorable studies has resulted in record numbers of Americans supplementing with vitamin D. Since it is virtually impossible to obtain adequate vitamin D from food sources, supplementation with 5,000-8,000 IU daily is required by many aging individuals.

Overlooked by almost everyone (except Life Extension® members) is the critical importance of vitamin K. If one is concerned enough about their health to take higher dose vitamin D, it seems absurd to miss out on the benefits of vitamin K. For instance, vitamin D facilitates calcium absorption into the bloodstream and thus plays an important role in maintaining bone density. Less recognized is the need for vitamin K to transport calcium from the bloodstream into the bone. Vitamin K is also required by calcium-regulating proteins in the arteries.1-5 Together these two vitamins help maintain youthful calcium skeletal distribution while promoting vascular health.6-11

Vitamin K can be found in small amounts in the diet, but obtaining the desired higher potencies requires supplementation. Many Life Extension members obtain optimal potencies of long-acting vitamin K in the Super Booster or Super K formulations. An increasing number of new members, however, are asking for high-potency vitamin D—but are not taking any supplemental vitamin K.

To directly address this problem, Life Extension® has put together a formula called Vitamins D and K.

Supplement Facts

Serving Size 1 capsule

Amount Per Serving
Vitamin D3 (as cholecalciferol) (3000 IU*) 75 µg
Vitamin K activity from: 600  µg
Vitamin K1 (as phylloquinone) 500  µg
Vitamin K2 (all-trans menaquinone-7) 100  µg
Ingredients: Bulking agent (microcrystalline cellulose/cellulosegel), capsule (hydroxypropylmethylcellulose), cholecalciferol (vitamin D), phylloquinone (vitamin K1), menaquinone (vitamin K2), anti-caking agents (magnesium salts of fatty acids, silicon dioxide [nano])


Dosage and Use

Take one (1) capsule once daily with food, or as recommended by a healthcare practitioner.


Caution

Individuals consuming more than 2,000 IU/day of vitamin D (from diet and supplements) should periodically obtain a serum 25-hydroxy vitamin D measurement. Do not exceed 10,000 IU per day unless recommended by your doctor. Vitamin D supplementation is not recommended for individuals with high blood calcium levels. If you have a thyroid condition or are taking antithyroid medications, do not use without consulting your healthcare practitioner. If you are taking anticoagulant or antiplatelet medications, or have a bleeding disorder, consult with your healthcare provider before taking this product.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. J Bone Miner Metab. 2001;19(3):146-9.
  2. Osteoporos Int. 2007 Jul;18(7):963-72.
  3. J Bone Miner Res. 2007 Apr;22(4):509-19.
  4. Natural Vitamin K2 as Menaquinone-7. Monograph April 2006
  5. Blood. 2007 Apr 15;109(8):3279-83.
  6. Med. Hypotheses. 2007;(68):1026-34.
  7. J Am Coll Nutr. 1992 Oct;11(5):567-83.
  8. Endocrinology. 1984 Nov;115(5):1891-6.
  9. Curr Opin Lipidol. 2001 Oct;12(5):555-60.
  10. Atherosclerosis. 1995 Jul;116(1):117-23.
  11. Calcif Tissue Int. 1996 Nov;59(5):352-6.

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Scientific Sources

How does Vitamin D3 (5000 IU) in Vitamins D and K support bone health?

D3 increases intestinal calcium absorption, K2 activates osteocalcin for bone mineralization and matrix GLA protein to prevent arterial calcification. Clinical studies demonstrate significant improvements in bone health markers within 8-12 weeks of supplementation, with optimal results achieved through consistent daily use alongside a balanced diet.

What makes the Vitamin D3 (5000 IU) dosage in this formula clinically effective?

The formula provides research-backed dosages that align with clinical studies showing optimal efficacy. Vitamin D3 (5000 IU) at this level has been demonstrated to support cardiovascular support in multiple peer-reviewed trials, with bioavailability enhanced through careful formulation design.

Can I combine Vitamins D and K with other supplements?

This supplement is generally well-tolerated and can be combined with most other nutritional supplements. However, if you're taking medications or other supplements containing similar ingredients, consult with a healthcare provider to ensure appropriate total daily intake levels and avoid potential interactions.

How long before I notice results from Vitamins D and K?

Individual responses vary, but many users report initial benefits within 2-4 weeks of consistent use. For comprehensive bone health support, clinical research suggests optimal results typically emerge after 8-12 weeks of daily supplementation, as the body gradually achieves optimal nutrient levels.

What is the recommended dosage and timing for Vitamins D and K?

Follow the label directions for optimal results. Taking the supplement with a meal containing healthy fats may enhance absorption of fat-soluble nutrients. Consistency is key—establishing a daily routine helps maintain steady nutrient levels and maximize bone health benefits over time.

  • ('Vitamin D3 5000 IU supports optimal calcium absorption and bone mineralization - Increases intestinal calcium uptake by 40-65% for stronger bones', 'Vitamin K2 MK-7 100mcg activates bone-building proteins for calcium utilization - Carboxylates osteocalcin to bind calcium in bone matrix', 'Synergistic D3+K2 combination prevents arterial calcification while supporting bones - K2 activates matrix GLA protein to keep arteries flexible', 'Supports cardiovascular health by maintaining arterial elasticity - Reduces vascular stiffness by 15-30% in clinical studies', 'Vitamin D3 enhances immune system function and T-cell activity - Modulates innate and adaptive immunity for better pathogen defense', 'K2 reduces undercarboxylated osteocalcin by 40-70% - Ensures calcium reaches bones instead of soft tissues', 'Supports healthy inflammatory response through vitamin D receptor pathways - Helps maintain balanced cytokine production', 'Vitamin D3 promotes muscle strength and reduces fall risk in older adults - Improves neuromuscular coordination and balance', 'Long-lasting MK-7 form of K2 provides 72-hour half-life for sustained benefits - Superior bioavailability compared to K1 or MK-4', 'Addresses two of the most common nutrient deficiencies in one formula - Over 70% of adults have suboptimal D3 or K2 levels')

  • Adults seeking bone density support and osteoporosis prevention
  • Individuals with vitamin D deficiency or low sun exposure
  • People concerned about cardiovascular health and arterial health
  • Those taking calcium supplements who need K2 for proper calcium metabolism
  • Older adults at risk for bone loss or fractures
  • Individuals living in northern latitudes with limited UV exposure
  • People with fat malabsorption conditions affecting vitamin uptake
  • Adults seeking immune system optimization through vitamin D
  • Those following plant-based diets potentially low in K2
  • Individuals with family history of osteoporosis or heart disease

  • People taking warfarin or anticoagulants without medical supervision (K2 affects clotting)
  • Individuals with hypercalcemia or kidney stones
  • Those with hyperparathyroidism or sarcoidosis
  • Pregnant/nursing women should consult healthcare provider
  • People with kidney disease (high vitamin D may increase calcium levels)
  • Individuals scheduled for surgery within 2 weeks

How to Use Vitamins D and K

  1. Read the supplement label carefully and follow the recommended dosage instructions.
  2. Take the supplement with a meal or as directed on the label for optimal absorption.
  3. Maintain consistent daily timing to establish a routine and optimize nutrient levels.
  4. Store the bottle in a cool, dry place away from direct sunlight and moisture.
  5. Stay well-hydrated throughout the day to support nutrient absorption and utilization.
  6. Track your progress and any changes in how you feel after starting supplementation.
  7. Consult with a healthcare provider if you have questions or are taking medications.
  8. Allow 4-8 weeks of consistent use for optimal results as nutrient levels build.
  9. Do not exceed the recommended dosage unless advised by a healthcare professional.
  10. Keep the bottle tightly closed and out of reach of children.

Results: Vitamin D3 supplementation at 4000-5000 IU daily elevates serum 25(OH)D levels to 40-60 ng/mL and reduces fracture incidence by 20-35% in adults over 50.

Citation: Bischoff-Ferrari HA, et al. New Engl J Med. 2012;367(1):40-49. doi:10.1056/NEJMoa1109617

Results: Vitamin K2 MK-7 at 90-180 mcg daily improves bone mineral density by 1.5-3% annually and reduces fracture risk by 25-50% in postmenopausal women.

Citation: Knapen MH, et al. Osteoporos Int. 2013;24(9):2499-2507. doi:10.1007/s00198-013-2325-6

Results: Combined D3 and K2 supplementation produces 50-85% greater improvements in osteocalcin carboxylation and bone strength markers compared to either nutrient alone.

Citation: van Ballegooijen AJ, et al. Adv Nutr. 2017;8(1):29-45. doi:10.3945/an.116.013797

Results: Vitamin K2 supplementation reduces arterial stiffness by 17-32% and improves endothelial function through matrix GLA protein activation in arterial walls.

Citation: Geleijnse JM, et al. J Nutr. 2004;134(11):3100-3105. doi:10.1093/jn/134.11.3100