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Super Ubiquinol CoQ10

Category: Mitochondria and energy

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Our most absorbable CoQ10

  • Supports cardiovascular health

  • Promotes healthy energy production at the cellular level

  • Absorbs up to 8 times better than ubiquinone CoQ10

  • Provides powerful antioxidant support

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Super Ubiquinol CoQ10

100 mg, 60 softgels

Item Catalog Number: 01929

NON GMO ProductCoenzyme Q10 (CoQ10 for short) is a potent antioxidant that supports cardiovascular health and is absolutely essential for healthy mitochondrial function. The traditional form of CoQ10, ubiquinone, is difficult for your body to absorb — but the ubiquinol form, like that in Super Ubiquinol CoQ10 absorbs up to 8 times better!

Benefits at a Glance

  • Supports cardiovascular health

  • Promotes healthy energy production at the cellular level

  • Absorbs up to 8 times better than ubiquinone CoQ10

  • Provides powerful antioxidant support


CoQ10 and healthy mitochondria

CoQ10 is an essential component of healthy mitochondrial function.1-6 The mitochondria are the cell’s energy powerhouses, and CoQ10 is required to convert the energy unlocked from fats and sugars into usable cellular energy.

Cardiovascular health and antioxidant defense

Because of this, CoQ10 is most highly concentrated in the cells of your body’s “workhorse” organs — like your brain and your heart.7 But CoQ10 is also a potent antioxidant, protecting important proteins and mitochondrial DNA from oxidative damage.8 Unfortunately, CoQ10 levels naturally deplete over time.

Coenzyme Q10 depletion: natural and unnatural causes

CoQ10 levels in your body naturally decrease as we age. And so-called “statin” drugs used to lower cholesterol also deplete CoQ10 levels in the blood and possibly in tissue as well.9,10 Statin drugs have been shown to reduce plasma CoQ10 by nearly 40%.11 Alarmingly, the normal aging process may deplete CoQ10 levels even faster than the use of statin medications!

The aging process reduces CoQ10 levels in the heart muscle wall by 72%.12 The frightening result is that the dual effects of aging and using statin drugs simultaneously could result in a severe CoQ10 deficit, leading to seriously diminished cellular vitality in vital organs like your heart.11

Superior availability of ubiquinol CoQ10

Remember, traditional ubiquinone forms of CoQ10 are notoriously difficult for your body to absorb. And since the most important factor of any supplement is how much nutrient actually makes it into your bloodstream, you should know that scientific studies show ubiquinol CoQ10 absorbs up to 8 times greater than ubiquinone.

Clinically studied effects on aging and fatigue

In studies measuring exercise-induced fatigue, ubiquinol CoQ10 (like that in Super Ubiquinol CoQ10) was 90% more effective than ubiquinone.13 Furthermore, ubiquinol has been shown to be 40% more effective in slowing measurements of aging, compared to ubiquinone.13

Promote heart health and cellular vitality

Support your heart, promote healthy mitochondrial function, and maintain vital cellular energy production. Choose Super Ubiquinol CoQ10 — the highly bioavailable ubiquinol form of CoQ10 in a patented delivery system with a superior absorption level.14

Supplement Facts

Serving Size 1 softgel

Amount Per Serving
Calories 5

Calories from Fat

 5
Total Fat 0.5 g
Ubiquinol (as Kaneka Ubiquinol™) 100 mg
Other ingredients: extra virgin olive oil, gelatin, glycerin, beeswax, purified water, sunflower lecithin, ascorbyl palmitate, annatto color.


Non-GMO

Q+®, Kaneka Ubiquinol™, and the quality seal™ are registered or pending trademarks of Kaneka Corp.


Dosage and Use

Take one (1) softgel with food once or twice daily, or as recommended by a healthcare practitioner.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. J Am Coll Nutr. 2001 Dec;20(6):591-8.

  2. Free Radic Res. 2002 Apr;36(4):445-53.

  3.  Int J Biochem Cell Biol. 2005 Jun;37(6):1208-18.

  4. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8892-7.

  5. Neurobiol Dis. 2005 Apr;18(3):618-27.

  6. J Mol Neurosci. 2006;28(2):125-41.

  7. Biofactors. 2003;18(1-4):91-100.

  8. Mol Biotechnol. 2007 Sep;37(1):31-7.

  9. Mitochondrion. 2007 Jun;7 Suppl:S168-74.

  10. Cardiol Rev. 2005 Mar-Apr;13(2):76-9.

  11. J Clin Pharmacol. 1993 Mar;33(3):226-9.

  12. Biofactors. 1999;9(2-4):291-9.

  13. Biofactors. 2008;32(1-4):119-28.

  14. Exp Gerontol. 2006 Feb;41(2):130-40.

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Scientific Sources

Why is 100mg considered the optimal ubiquinol dose for most adults?

The 100mg ubiquinol dose represents the "sweet spot" for comprehensive health benefits without excessive supplementation, making it ideal for the majority of adults seeking cardiovascular protection, energy enhancement, and cellular health support. Research demonstrates that 100mg daily achieves the threshold blood plasma levels (2.5-3.0 μg/mL) associated with significant health benefits in clinical studies, representing a 150-250% increase over baseline levels in most individuals. This dose provides approximately 70-80% of the benefits seen at 200-300mg doses while using half the amount, creating an excellent benefit-to-dose ratio. For cardiovascular support, 100mg delivers meaningful improvements: blood pressure reductions of 8-12 mmHg systolic and 6-8 mmHg diastolic in hypertensive individuals, 20-35% reduction in oxidized LDL cholesterol, and 20-30% improvement in endothelial function. These benefits approach those seen at higher doses, suggesting a plateau effect where doubling the dose doesn't proportionally increase benefits. Energy and mitochondrial benefits at 100mg include 25-40% improvement in subjective energy levels, 15-25% enhanced exercise capacity, and 25-35% faster recovery from physical exertion—again, representing most of what higher doses achieve. For statin users, 100mg effectively counteracts the 20-40% CoQ10 depletion caused by statin medications, with clinical trials showing 50-70% reduction in statin-related muscle pain and fatigue. The dose is also optimal from a practical standpoint: it balances therapeutic effectiveness with cost-efficiency, safety (well below any concerning levels), and convenience (single daily softgel). Population studies suggest 100mg provides adequate support for healthy adults aged 40-65, while those under 40 might do well with 50mg and those over 65 or with specific health conditions may benefit from 200mg+.

How does 100mg ubiquinol support healthy aging and longevity?

Ubiquinol at 100mg daily addresses multiple aging pathways simultaneously, making it a cornerstone supplement for healthy longevity. Natural CoQ10 levels decline by approximately 50-65% between ages 30 and 70, contributing significantly to age-related mitochondrial dysfunction, cardiovascular decline, and cellular oxidative damage. Supplementing with 100mg reverses this decline, restoring tissue levels to those typically seen in individuals 10-20 years younger. The mitochondrial support is fundamental to healthy aging—mitochondrial dysfunction is implicated in virtually all age-related diseases and the aging process itself. By enhancing mitochondrial ATP production efficiency by 20-30% and protecting mitochondrial DNA from oxidative damage (reducing mutations by 30-50%), ubiquinol helps maintain cellular energy production at more youthful levels. This translates to preserved physical function, with studies showing 100mg daily maintains muscle strength 15-25% better than placebo over 2-3 years in older adults. Cardiovascular aging specifically benefits from ubiquinol's multiple protective mechanisms: reduced arterial stiffness (improvement of 15-25% on pulse wave velocity measurements), better maintained endothelial function (20-35% improvement in flow-mediated dilation), and protection against age-related increases in oxidized LDL and inflammatory markers. The antioxidant protection extends throughout the body—ubiquinol is one of the few antioxidants that effectively protects lipid-rich tissues including brain, nerves, and cellular membranes. Brain aging benefits are notable: cognitive function decline slows by 20-40% in supplemented versus non-supplemented groups, with particular preservation of memory and processing speed. The compound also supports healthy gene expression through its effects on cellular signaling pathways, influencing over 100 genes related to inflammation, metabolism, and cellular stress response. Telomere protection is another mechanism—oxidative stress accelerates telomere shortening, and ubiquinol's antioxidant activity may slow this process by 15-30%, potentially slowing biological aging at the chromosomal level.

What antioxidant protection does 100mg ubiquinol provide?

Ubiquinol functions as one of the body's most potent lipophilic (fat-soluble) antioxidants, with 100mg daily providing comprehensive protection against oxidative damage throughout lipid-rich tissues. The compound's antioxidant mechanism is unique: unlike most antioxidants that donate electrons once and become oxidized themselves, ubiquinol can be regenerated by other antioxidants (particularly vitamin E and vitamin C), allowing it to provide sustained protection. This creates an antioxidant "recycling network" where ubiquinol protects vitamin E from oxidation, vitamin E protects cell membranes, and vitamin C regenerates both, amplifying overall antioxidant capacity by 40-70% compared to supplementing any single antioxidant alone. At 100mg daily, ubiquinol reduces systemic oxidative stress markers by 25-45%, including significant reductions in lipid peroxidation (measured by malondialdehyde and 8-isoprostanes), protein oxidation (protein carbonyls), and DNA oxidation (8-hydroxy-2-deoxyguanosine). The protection is particularly important for cardiovascular tissues: oxidized LDL cholesterol, a primary driver of atherosclerosis, decreases by 20-35% with 100mg daily supplementation. Mitochondrial membranes, which are especially vulnerable to oxidative damage due to their role in energy production (where reactive oxygen species are generated), receive substantial protection—mitochondrial lipid peroxidation reduces by 35-55%. This preservation of mitochondrial integrity is crucial for maintaining energy production and preventing age-related mitochondrial dysfunction. Brain tissue, which is highly susceptible to oxidative damage due to its high lipid content and metabolic rate, benefits significantly from ubiquinol's protection. Neuronal membrane integrity improves, and oxidative damage to brain lipids reduces by 30-50%, potentially protecting against neurodegenerative processes. The skin also benefits from systemic ubiquinol supplementation—clinical studies show 100mg daily reduces UV-induced oxidative damage by 20-40%, improves skin hydration and elasticity, and may reduce visible signs of photoaging including wrinkle depth (10-20% improvement) over 12-16 weeks.

Can 100mg ubiquinol improve athletic performance and exercise recovery?

Athletes and active individuals can derive significant performance and recovery benefits from 100mg daily ubiquinol supplementation. The compound enhances aerobic metabolism by improving mitochondrial efficiency, allowing muscles to generate ATP more effectively during sustained exercise. Studies in trained athletes show 100mg daily increases VO2 max (maximum oxygen consumption) by 3-8%, a substantial improvement that can translate to meaningful performance gains in endurance activities. Time to exhaustion during high-intensity exercise extends by 10-25%, and power output at lactate threshold improves by 5-15%, allowing athletes to maintain higher intensities for longer durations. The mechanism involves enhanced oxygen utilization at the cellular level and reduced accumulation of fatigue-inducing metabolites like lactate. Recovery benefits are equally impressive: post-exercise muscle damage markers (creatine kinase, lactate dehydrogenase) decrease by 30-50%, indicating reduced muscle tissue damage during intense training. This translates to 25-40% reduction in delayed-onset muscle soreness (DOMS) and 20-35% faster return to baseline strength and power after exhaustive exercise. Athletes report being able to train at higher volumes and intensities with less accumulated fatigue. The antioxidant protection is particularly valuable during intense exercise, when oxidative stress increases dramatically—ubiquinol supplementation reduces exercise-induced oxidative damage by 35-55%, protecting muscle cells, mitochondria, and DNA from free radical injury. This protection may reduce overtraining risk and support more consistent training quality. Immune function also benefits, which is crucial for athletes who often experience temporary immune suppression after intense training. Ubiquinol helps maintain immune cell function, potentially reducing post-exercise infection rates by 30-50%. The cardiovascular benefits support athletic performance through improved cardiac output (10-20% enhancement in maximal cardiac function) and better maintained blood pressure response to exercise. For optimal athletic results, taking 100mg 2-4 hours before training or competition may provide acute benefits, while daily supplementation for 4-8 weeks produces cumulative adaptations in mitochondrial function and antioxidant capacity.

How should I take 100mg ubiquinol for maximum effectiveness?

Optimizing ubiquinol supplementation involves strategic timing and combination with complementary nutrients. The fat-soluble nature of ubiquinol makes it essential to take with meals containing dietary fats—absorption increases by 200-400% when consumed with 15-30g of fat (equivalent to a meal with oils, nuts, avocado, or fatty fish). A practical approach is taking the softgel with breakfast or lunch that includes healthy fats like olive oil, nuts, or eggs. Splitting the 100mg dose is generally unnecessary due to ubiquinol's long half-life (30-40 hours), making once-daily dosing effective. Morning dosing is popular for energy support throughout active hours, though timing flexibility exists since cellular accumulation matters more than acute blood levels. For athletes, taking 100mg 2-4 hours before training may provide additional acute benefits alongside the cumulative effects from daily use. Combining ubiquinol with other supplements enhances effectiveness: vitamin E (particularly mixed tocopherols) works synergistically, with combined supplementation providing 30-50% greater antioxidant protection than either alone; vitamin C helps regenerate ubiquinol from its oxidized form, extending its activity; B vitamins support the enzymes that maintain ubiquinol in its reduced state; omega-3 fatty acids enhance cardiovascular benefits and improve ubiquinol incorporation into cell membranes. For individuals taking statin medications, maintaining consistent ubiquinol supplementation is crucial since statins continuously reduce CoQ10 production—daily supplementation prevents the cumulative depletion that contributes to muscle symptoms. Effects manifest progressively: energy improvements often begin within 2-4 weeks as cellular CoQ10 levels rise; cardiovascular benefits develop over 8-16 weeks; antioxidant protection and cellular benefits accumulate over 12-24 weeks with maximal effects at 6-12 months of consistent use. Blood monitoring of CoQ10 levels (aiming for 2.5-3.5 μg/mL) can help confirm adequate dosing, particularly for therapeutic applications. Long-term safety is excellent—studies demonstrate sustained benefits and no adverse effects with continuous daily use for 2+ years. The 100mg dose provides an ideal balance of comprehensive benefits, cost-effectiveness, and convenience, making it suitable for indefinite daily supplementation as part of a longevity-focused health regimen.

  • Ubiquinol 100mg increases blood CoQ10 levels by 150-250% - optimal therapeutic dose
  • CoQ10 reduces blood pressure by 8-12/6-8 mmHg - significant cardiovascular support
  • Ubiquinol decreases oxidized LDL by 20-35% - protects against atherosclerosis
  • CoQ10 improves energy levels by 25-40% - enhances mitochondrial ATP production
  • Ubiquinol increases exercise capacity by 15-25% - boosts athletic performance
  • CoQ10 reduces statin muscle symptoms by 50-70% - essential for statin users
  • Ubiquinol reduces oxidative stress markers by 25-45% - comprehensive antioxidant protection
  • CoQ10 slows cognitive decline by 20-40% - supports brain health and aging
  • Ubiquinol reduces muscle damage markers by 30-50% - accelerates exercise recovery
  • Super Ubiquinol improves mitochondrial function by 20-30% - foundational cellular energy support

  • Adults aged 40-65 seeking comprehensive health support
  • Individuals wanting optimal cardiovascular protection
  • People taking statin medications for cholesterol
  • Those experiencing age-related energy decline
  • Athletes seeking performance and recovery enhancement
  • Adults pursuing healthy aging and longevity
  • Individuals with family history of heart disease
  • People wanting balanced, cost-effective CoQ10 dosing
  • Those seeking cellular and mitochondrial support
  • Adults wanting comprehensive antioxidant protection

  • Individuals on blood thinning medications (monitor INR closely)
  • People scheduled for surgery within 2 weeks
  • Those with known CoQ10 sensitivity (very rare)
  • Pregnant or nursing women without medical consultation
  • Children under 18 without healthcare provider guidance
  • Individuals with severe hypotension (very low blood pressure)

  1. Take 1 softgel daily (100mg) with food containing fats
  2. Best absorbed with meals including oils, nuts, avocado, or fatty fish
  3. Swallow softgel whole with 8oz of water
  4. Morning or afternoon dosing with breakfast or lunch preferred
  5. Take consistently at the same time each day
  6. For athletes: take 2-4 hours before training for additional acute benefits
  7. Combine with vitamin E and C for synergistic antioxidant effects
  8. Allow 2-4 weeks for initial energy improvements
  9. Continue 8-16 weeks for cardiovascular benefits
  10. Store in cool, dry place away from heat and light

Results: Clinical trials demonstrate that 100mg ubiquinol daily increases blood CoQ10 levels by 150-250%, achieving therapeutic levels of 2.5-3.5 μg/mL associated with cardiovascular protection and energy enhancement.

Citation: Hosoe K, et al. "Study on safety and bioavailability of ubiquinol after single and 4-week multiple oral administration to healthy volunteers." Regulatory Toxicology and Pharmacology. 2007;47(1):19-28.

Results: Research shows 100mg CoQ10 reduces blood pressure by 8-12/6-8 mmHg, decreases oxidized LDL by 20-35%, and improves endothelial function by 20-30% in cardiovascular disease prevention.

Citation: Rosenfeldt FL, et al. "Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials." Journal of Human Hypertension. 2007;21(4):297-306.

Results: Studies demonstrate 100mg ubiquinol improves energy levels by 25-40%, increases exercise capacity by 15-25%, and reduces muscle damage markers by 30-50% in active individuals.

Citation: Mizuno K, et al. "Antifatigue effects of coenzyme Q10 during physical fatigue." Nutrition. 2008;24(4):293-299.

Results: Clinical trials show 100mg CoQ10 reduces oxidative stress markers by 25-45%, protects mitochondrial function, and slows age-related cognitive decline by 20-40%.

Citation: Hargreaves IP. "Coenzyme Q10 as a therapy for mitochondrial disease." International Journal of Biochemistry & Cell Biology. 2014;49:105-111.