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Extend-Release Magnesium EU

Category: Minerals

Manufacturer:

Essential magnesium nutrient in a 6-hour formula

  • Magnesium oxide for long term absorption

  • Magnesium citrate for immediate uptake

  • Essential for more than 300 biochemical reactions

  • Combats widespread magnesium insufficiency

  • Supports cardiovascular health, bone health, and more

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Extend-Release Magnesium

60 vegetarian capsules

Item Catalog Number: 02107EU

NON GMO ProductYour body needs the trace mineral magnesium for more than 300 essential biochemical reactions, but most of us don't get enough magnesium from dietary sources alone. Extend-Release Magnesium is formulated with magnesium oxide for extended release and magnesium citrate for immediate absorption. By combining magnesium optimized for immediate and prolonged uptake, this advanced formula provides more consistent results.

Benefits at a Glance:

  • Magnesium oxide for long term absorption

  • Magnesium citrate for immediate uptake

  • Essential for more than 300 biochemical reactions

  • Combats widespread magnesium insufficiency

  • Supports cardiovascular health, bone health, and more

Magnesium when and where you need it most

Life Extension customers have known about the health benefits of magnesium for years. Now, Life Extension offers Extend-Release Magnesium. Formulated with two kinds of magnesium, Extend-Release Magnesium is optimized for both immediate and prolonged dissolution and uptake. Extend-Release Magnesium ensures you get the maximum health benefits magnesium can provide, making it our most advanced magnesium supplement ever.

Cardiovascular health

Magnesium relaxes the smooth muscles within the blood vessels, promoting cardiovascular health.1-4 Magnesium promotes the synthesis of serotonin and nitric oxide.5-7

Bone health

Magnesium positively influences the bone mineral matrix and its ability to metabolize minerals needed for optimal bone health.8,9 Scientific literature documents the need for a number of minerals, including calcium and magnesium, to help maintain strong, healthy bones.

Whole body health

Dietary magnesium also improves metabolic profile,10-12 beneficially impact insulin resistance, serum lipid profiles, promote a healthy inflammatory response, support healthy endothelial function, and protect against oxidative stress.13,14



Supplement Facts

Serving Size 1 vegetarian capsule

Amount Per Serving
Magnesium (as ZümXR® magnesium oxide, magnesium citrate) 250 mg
Other ingredients:  rice concentrate, vegetable cellulose (capsule), microcrystalline cellulose, ethylcellulose, hydroxypropyl methylcellulose, medium chain triglycerides, oleic acid, silica.


Non-GMO

ZümXR® is a registered trademark and protected by patents. See www. ZümXR.com.


Dosage and Use

Take one (1) capsule once or twice daily, with or without food, or as recommended by a healthcare practitioner.


Caution

If taken in high doses, magnesium may have a laxative effect. If this occurs, divide dosing, reduce intake, or discontinue product.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. J Clin Hypertens (Greenwich). 2011 Nov;13(11):843-7.

  2. Br J Sports Med. 2006 Sep;40(9):773-8.

  3. Congest Heart Fail. 2006 Jan-Feb;12(1):9-13

  4. Magnes Res. 2010 Jun;23(2):60-72.

  5. Hypertension. 2004 Dec;44(6):897-902.

  6. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17;33(2):235-42.

  7. Amino Acids. 2002 Jun;22(4):381-9.

  8. J Clin Endocrinol Metab. 1998 Aug;83(8):2742-8.

  9. Biol Trace Elem Res. 2010 Feb;133(2):136-43.

  10. Magnes Res. 2007 Jun;20(2):107-29.

  11. Public Health Nutr. 2012 Apr;15(4):693-701.

  12. Clin Cardiol. 2000 Jun;23(6):433-6.

  13. Curr Opin Lipidol. 2008 Feb;19(1):50-6.

  14. Eur J Clin Invest. 2011 Apr;41(4):405-10.

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Scientific Sources

What is Extend-Release Magnesium and how does it differ from regular magnesium?

Extend-Release Magnesium uses advanced microencapsulation technology to deliver magnesium gradually over an extended period rather than all at once. This controlled-release formulation provides sustained magnesium absorption throughout the day, maintaining more stable blood levels compared to immediate-release forms. The extended release also significantly reduces the digestive discomfort and laxative effects that some people experience with standard magnesium supplements, particularly at higher doses. This makes it possible to achieve optimal magnesium intake without the unpleasant side effects, ensuring better compliance and more consistent health benefits.

Why is magnesium deficiency so common and how can I tell if I need supplementation?

Studies suggest nearly half of adults don't meet the recommended daily magnesium intake through diet alone. Modern soil depletion has reduced magnesium content in foods, while food processing further decreases levels. Certain medications like proton pump inhibitors and diuretics deplete magnesium stores. High stress, caffeine consumption, and intense exercise all increase magnesium requirements. Common signs of deficiency include muscle cramps or twitches, poor sleep quality, occasional fatigue, irritability, and difficulty managing stress. However, many people with suboptimal magnesium levels have no obvious symptoms, making supplementation beneficial for general health maintenance even without overt deficiency signs.

What health benefits can I expect from Extend-Release Magnesium?

Magnesium participates in over 300 enzymatic reactions, providing wide-ranging health benefits. It supports cardiovascular health by helping maintain healthy blood pressure and heart rhythm. Magnesium is essential for bone health, working with calcium and vitamin D for optimal bone density. It promotes muscle relaxation, reducing occasional cramps and supporting comfortable muscle function. Magnesium supports restful sleep by regulating neurotransmitters and promoting relaxation. It helps maintain healthy blood sugar metabolism and insulin sensitivity. The mineral supports nervous system function, helping manage stress responses and promoting calm mood. Energy production at the cellular level requires magnesium for ATP synthesis.

How does the extend-release formula minimize digestive side effects?

Standard magnesium supplements release all their magnesium quickly in the digestive tract, overwhelming absorption capacity and drawing water into the intestines, causing loose stools. The extend-release technology encapsulates magnesium in a special matrix that dissolves slowly over several hours. This gradual release means smaller amounts of magnesium are presented to the intestinal wall at any given time, allowing more complete absorption while minimizing the osmotic effect that causes digestive upset. The result is better tolerance, reduced laxative effects, and improved bioavailability, making it easier to achieve optimal magnesium levels without discomfort.

When is the best time to take Extend-Release Magnesium?

Timing depends on your primary health goals. For sleep support, take 1-2 hours before bedtime as magnesium promotes relaxation and supports healthy sleep patterns. For muscle relaxation and recovery, take after exercise or in the evening. For general health maintenance, taking with dinner works well as the extended release continues working overnight. For blood sugar support, split doses between meals if taking higher amounts. The extended-release formula means you have flexibility in timing since magnesium is released gradually. Consistency matters more than specific timing—choose a schedule you can maintain daily for optimal benefits.

  • Provides sustained gradual magnesium release over extended period for stable levels - extended release
  • Minimizes digestive discomfort with extended-release magnesium and laxative effects - better tolerance
  • Magnesium supports cardiovascular health including healthy blood pressure and heart rhythm - heart support
  • Promotes strong healthy bones with magnesium working synergistically with calcium vitamin D - bone health
  • Magnesium helps maintain comfortable muscle function and reduces occasional cramps - muscle support
  • Supports restful sleep quality with magnesium and promotes natural relaxation - sleep support
  • Magnesium essential for cellular energy production and ATP synthesis in mitochondria - energy support
  • Helps maintain healthy blood sugar metabolism with magnesium and insulin sensitivity - metabolic health
  • Magnesium supports nervous system function and healthy stress response management - stress support
  • Participates in over 300 enzymatic reactions with magnesium throughout entire body - foundational mineral

  • Adults not meeting dietary magnesium requirements who need convenient supplementation option
  • People experiencing digestive sensitivity with standard magnesium supplements needing gentler formula
  • Individuals with occasional muscle cramps tension or spasms seeking natural relief support
  • Those having difficulty with sleep quality wanting natural relaxation and rest support
  • Active individuals with increased magnesium needs from exercise and physical stress demands

  • People with kidney disease or impaired kidney function should avoid magnesium supplements
  • Those with heart block or certain cardiac arrhythmias should consult doctor first
  • Individuals taking antibiotics should space magnesium intake by several hours appropriately
  • People on bisphosphonate medications should verify proper timing with healthcare provider
  • Those experiencing chronic diarrhea should seek medical guidance before supplementation

  1. Take recommended dose with water preferably with meals for enhanced absorption
  2. For sleep support take 1-2 hours before bedtime to promote relaxation
  3. Swallow tablets whole without crushing to preserve extended-release technology benefits
  4. Space magnesium intake 2-3 hours from calcium zinc or iron supplements if taking
  5. Maintain consistent daily use at same time each day for optimal health benefits
  6. Stay well-hydrated throughout day when supplementing with magnesium
  7. Start with recommended dose as extended-release formula minimizes digestive effects
  8. Store in cool dry place away from moisture to maintain product quality

Results: Clinical studies demonstrate extended-release magnesium formulations provide more sustained blood magnesium levels over 8-12 hours compared to immediate-release forms, with significantly reduced gastrointestinal side effects and improved tolerance at equivalent or higher doses.

Citation: Firoz M, Graber M. Magnes Res. 2001 Dec;14(4):257-62.

Results: Research shows magnesium supplementation supports healthy blood pressure maintenance, with meta-analyses indicating 3-4 mmHg reductions in systolic and 2-3 mmHg reductions in diastolic pressure, particularly beneficial for individuals with borderline hypertension or metabolic concerns.

Citation: Zhang X, et al. Hypertension. 2016 Aug;68(2):324-33.

Results: Studies indicate magnesium plays crucial role in bone mineral density, with higher magnesium intake associated with increased bone mass and reduced fracture risk in longitudinal studies, working synergistically with calcium and vitamin D for optimal skeletal health.

Citation: Castiglioni S, et al. Nutrients. 2013 Aug;5(8):3022-33.

Results: Clinical trials demonstrate magnesium supplementation improves sleep quality and duration, reduces time to fall asleep, and increases sleep efficiency in individuals with occasional insomnia or inadequate magnesium status, supporting healthy circadian rhythm regulation.

Citation: Nielsen FH, et al. Magnes Res. 2010 Dec;23(4):158-68.