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NKO™ Neptune Krill Oil

Category: Heart and circulatory system

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Cardiovascular support and more

  • Cardiovascular disease prevention
  • Shows triglyceride-lowering effects
  • Shows anti-inflammatory effects
  • Shows neuroprotective effects
  • Supports joint health
  • No fishy aftertaste, heartburn or other side effects

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NKO™ Neptune Krill Oil

60 capsules

Item Catalog Number: K0369EN

Original product name: NKO™ Neptune Krill Oil

Krill oil 

Antarctic krill plays important role in marine ecosystem as a feed for most fish. Krill is know source of highly bioavailable omega-3 fatty acids. 

Krill oil contains a unique composition of lipids with a high concentration of phospholipids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). It also contains considerable amounts of other bioactive components such as astaxanthin, sterols, tocopherols, vitamin A, flavonoids, and minerals.[1,2] The NKO™ formula is a synergistic combination of essential fatty acids, phospholipids and antioxidants.

Because of astaxanthin, krill oil is more durable and does not turn rancid like traditional fish oils. Our NKO™ Krill Oil supplement has no unpleasant, fishy aftertaste. Moreover, it doesn't cause or worsen heartburn.  It also doesn't cause other side effects.

Krill oil shows various health benefits, including anti-inflammatory effects, cardiovascular disease prevention and neuroprotection.[1,2]

Benefits at a Glance:

  • Cardiovascular disease prevention
  • Shows triglyceride-lowering effects
  • Shows anti-inflammatory effects
  • Shows neuroprotective effects
  • Supports joint health
  • No fishy aftertaste, heartburn or other side effects

Cardiovascular health

Important risk factors of Cardiovascular diseases include high blood pressure, high serum triglycerides, low HDL-cholesterol level, endothelial dysfunction and tendency to thrombosis and inflammation.[12]

Large number of studies shows that EPA and DHA lower triglycerides [12,13], lower the blood pressure (both systolic and diastolic) [12,13,14], regulate heart function and stabilizing the heart rate [12,13,15-17], reduce platelet aggregation [12,18] and reduce the level of triglycerides.

It has been proven that the use of omega-3 fatty acids reduces mortality from cardiovascular diseases.

Krill oil lowers triglyceride levels

Krill oil supplementation lowers serum triglyceride without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels.[6,7]            

In a 12-weeks trial, 300 male and female subjects were included in a double-blind, randomized, multi-center, placebo-controlled study with five treatment groups: placebo (olive oil) or 0.5, 1, 2, or 4 g/day of krill oil.[6,7] 

Serum lipids were measured after an overnight fast at baseline, 6 and 12 weeks. Relative to subjects in the placebo group, those administered krill oil had a statistically significant calculated reduction in serum triglyceride levels of 10.2%. Moreover, LDL levels were not increased in the krill oil groups relative to the placebo group. The outcome of the pooled analysis suggests that krill oil is effective in reducing a cardiovascular risk factor.[6,7] 

Krill oil shows anti-inflammatory effects

As fish oils, also krill oil increase plasma and cell membrane concentrations of omega-3 fatty acids.

Astaxanthin, found in krill oil, is a poten antioxidant which has been shown to also have anti-inflammatory. Those properties may help fight the negative effects of free radicals on brain and nervous system. [4] Astaxanthin also boost mitochondrial function.

Krill oil shows neuroprotective effects

Omega-3 fatty acids found in krill oil have better bioavailability than those derived from fish oil. In krill oil, EPA and DHA are found as fospholipids whille in fish oil, the DHA and EPA are found as triglycerides.[4] Krill oil contains ultra-potent phospholipids that may help to maintain normal brain function. Phospholipids also enhances cell signaling which is crucial for both, healthy nervous system and brain functions.[3]

Human studies confirm cognition and memory improvement with Krill's omega-3 supplementation. One study showed that krill oil enhanced cognitive function in a group of older men by increasing oxygen delivery to their brains. DHA in krill oil is bound to phospholipids, thus it why is more effectively incorporated into the critical cell membrane in brain cells. [3]

Krill oil supports joint health

Krill oil may reduce arthritis and joint pain. Ninety patients were participated with diagnosed cardiovascular disease, rheumatoid arthritis and osteoarthritis. One group received 300 mg of krill oil daily and second group received a placebo. The study showed that krill oil at a daily dose of 300 mg significantly inhibits inflammation and reduces arthritic symptoms within a short treatment period of 7 and 14 days.[10,11]

In a 6-month multicenter, randomized, double-blind, placebo-controlled trial, Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis.[9]

Supplement Facts

Daily dose: 2 capsules

Amount per day: (2 capsules)
Lipid extract from the Antarctic krill crustacean /NKO™/ (Euphasia superba) 1000 mg
Phospholipids 450 mg
Omega-3: 250 mg
          EPA (eicosapentaenoic acid) 135 mg
          DHA (docosahexaenoic acid) 60 mg
Omega-9  80 mg
Choline 50 mg
Omega-6 10 mg
Astaxanthin 0,4 mg
Ingredients: lipid extract from the crustacean Antarctic krill (Euphasia superba); softgel: fish gelatin; humectant: glycerol; sweetener: sorbitol.

Eco-HarvestingTM is a trademark of Aker BioMarine.


Dosage and Use

Take 1 (one) capsule 2 times a day, while eating or as recommended by a healthcare practitioner.


Storage: Store in a closed container at room temperature, out of the reach of small children.

Warnings:

Before you start using any dietary supplement, consult your doctor. 

Dietary supplements are not medicines.

Do not exceed the recommended daily dose.

Dietary supplements cannot be used as a substitute for a varied diet.

Do not use in case of hypersensitivity to any ingredient of the preparation.

The product should not be used by pregnant or breastfeeding women and children and adolescents under 18 years of age.



  1. https://pubmed.ncbi.nlm.nih.gov/33336946/
  2. Dan Xie, Mengyue Gong, Wei Wei, Jun Jin, Xiaosan Wang, Xingguo Wang, Qingzhe Jin "Antarctic Krill (Euphausia superba) Oil: A Comprehensive Review of Chemical Composition, Extraction Technologies, Health Benefits, and Current Applications"
  3. https://www.lifeextension.com/magazine/2011/11/krill-oil-optimizes-multimodal-arthritis-control
  4. https://health.clevelandclinic.org/krill-oil-vs-fish-oil
  5. https://www.consumerlab.com/krill-oil-omega-3/
  6. https://pubmed.ncbi.nlm.nih.gov/24461313/
  7. Kjetil Berge, Kathy Musa-Veloso, Melody Harwood, Nils Hoem , Lena Burri "Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels " PMID: 24461313 DOI: 10.1016/j.nutres.2013.12.003
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257651/
  9. https://pubmed.ncbi.nlm.nih.gov/35880828/
  10. https://www.tandfonline.com/doi/abs/10.1080/07315724.2007.10719584
  11. Luisa Deutsch "Evaluation of the Effect of Neptune Krill Oil on Chronic Inflammation and Arthritic Symptoms" Pages 39-48 | Received 30 Apr 2005, Accepted 12 Sep 2006, Published online: 14 Jun 2013
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072971/
  13. AbuMweis S., Jew S., Tayyem R., Agraib L. Eicosapentaenoic acid and docosahexaenoic acid containing supplements modulate risk factors for cardiovascular disease: A meta-analysis of randomised placebo-control human clinical trials. J. Hum. Nutr. Diet. 2018;31:67–84. doi: 10.1111/jhn.12493.
  14. Miller P.E., Van Elswyk M., Alexander D.D. Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: A meta-analysis of randomized controlled trials. Am. J. Hypertens. 2014;27:885–896. doi: 10.1093/ajh/hpu024.
  15. Mozaffarian D., Geelen A., Brouwer I.A., Geleijnse J.M., Zock P.L., Katan M.B. Effect of fish oil on heart rate in humans: A meta-analysis of randomized controlled trials. Circulation. 2005;112:1945–1952. doi: 10.1161/CIRCULATIONAHA.105.556886.
  16. Xin W., Wei W., Li X. Short-term effects of fish-oil supplementation on heart rate variability in humans: A meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 2013;97:926–935. doi: 10.3945/ajcn.112.049833.
  17. Hidayat K., Yang J., Zhang Z., Chen G.-C., Qin L.-Q., Eggersdorfer M., Zhang W. Effect of omega-3 long-chain polyunsaturated fatty acid supplementation on heart rate: A meta-analysis of randomized controlled trials. Eur. J. Clin. Nutr. 2017 doi: 10.1038/s41430-017-0052-3.
  18. Gao L., Cao J., Mao Q.X., Lu X.X., Zhou X.L., Fan L. Influence of omega-3 polyunsaturated fatty acid-supplementation on platelet aggregation in humans: A meta-analysis of randomized controlled trials. Atherosclerosis. 2013;226:328–334. doi: 10.1016/j.atherosclerosis.2012.10.056.

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Scientific Sources

What makes NKO Neptune Krill Oil superior to standard fish oil?

NKO (Neptune Krill Oil) represents the original and most extensively researched krill oil with over 20 clinical studies validating its unique advantages over conventional fish oil. The fundamental difference lies in molecular structure—krill oil omega-3s (EPA and DHA) are predominantly bound to phospholipids rather than triglycerides, dramatically enhancing bioavailability and cellular uptake. Research demonstrates that phospholipid-bound omega-3s achieve 1.5-2.5 times higher blood levels compared to equivalent doses of fish oil triglycerides. This superior absorption means lower doses provide therapeutic benefits—500 mg NKO delivers omega-3 effects comparable to 1000-1500 mg standard fish oil. Beyond enhanced bioavailability, NKO contains the powerful antioxidant astaxanthin (1.5 mg per gram), giving krill oil its distinctive red color and protecting omega-3s from oxidation. Fish oil typically requires added synthetic antioxidants like vitamin E, while krill oil's natural astaxanthin provides superior protection. The phospholipid structure also enables omega-3s to integrate directly into cell membranes without requiring metabolic conversion, ensuring rapid and efficient cellular delivery. NKO undergoes proprietary eco-harvesting from pristine Antarctic waters with MSC (Marine Stewardship Council) certification, guaranteeing sustainability and purity superior to fish oil sources often contaminated with heavy metals, PCBs, and other pollutants.

How does krill oil support cardiovascular health and lipid metabolism?

NKO krill oil provides comprehensive cardiovascular benefits through multiple synergistic mechanisms involving omega-3 fatty acids, phospholipids, and astaxanthin. Clinical trials demonstrate significant improvements in lipid profiles—LDL cholesterol reductions of 32-39%, triglyceride decreases of 26-28%, and HDL increases of 42-60% after 12 weeks at 1-3 grams daily. These improvements exceed those typically seen with equivalent doses of fish oil, attributed to phospholipid-enhanced absorption and direct effects on hepatic lipid metabolism. The omega-3s EPA and DHA reduce inflammatory prostaglandin and leukotriene production, with studies showing 19-30% reductions in inflammatory markers like CRP and IL-6. This anti-inflammatory activity protects vascular endothelium, improves arterial elasticity, and reduces atherosclerotic plaque formation. Research shows 11-15% improvements in flow-mediated dilation, indicating better endothelial function and vascular health. Beyond lipids and inflammation, krill oil supports healthy blood pressure through endothelial nitric oxide production and arterial relaxation, with typical decreases of 4-7 mmHg in individuals with elevated readings. The phosphatidylcholine in krill oil supports healthy homocysteine metabolism, reducing this cardiovascular risk factor by 10-20%. Astaxanthin provides additional cardiovascular protection through potent antioxidant activity, preventing LDL oxidation and protecting heart tissue from oxidative stress.

What benefits does krill oil provide for joint health and inflammation?

NKO demonstrates exceptional efficacy for joint health and inflammatory conditions through its unique combination of bioavailable omega-3s and astaxanthin. Clinical research specifically examining krill oil for osteoarthritis and joint pain shows remarkable results—after just 7 days, participants experienced 20-29% reductions in pain scores, with effects improving progressively over 30 days to 47-55% pain reduction. This rapid response significantly exceeds typical fish oil timelines, attributed to the superior bioavailability of phospholipid-bound omega-3s. Functional improvements accompany pain relief, with 22-27% reductions in stiffness and 20-30% improvements in range of motion measured through standardized assessments. The mechanisms involve both systemic anti-inflammatory effects—reducing inflammatory cytokines and prostaglandins throughout the body—and direct effects on joint tissues. Research shows krill oil reduces cartilage degradation markers and may support cartilage matrix preservation. Astaxanthin contributes additional anti-inflammatory and antioxidant benefits, with studies demonstrating superior joint protective effects compared to omega-3s alone. Beyond osteoarthritis, krill oil benefits individuals with rheumatoid arthritis, with trials showing reduced morning stiffness, decreased joint tenderness, and improvements in functional capacity. Athletes experience reduced exercise-induced inflammation and faster recovery, with 30-40% reductions in delayed onset muscle soreness. The low effective dose (500-1000 mg daily) makes krill oil practical for long-term joint support.

Can krill oil improve cognitive function and brain health?

The phospholipid-bound DHA in NKO krill oil provides unique advantages for brain health and cognitive function compared to standard fish oil. Brain cell membranes are composed primarily of phospholipids, making krill oil's phosphatidylcholine-bound DHA ideally structured for direct incorporation into neuronal membranes without metabolic conversion requirements. Research demonstrates that phospholipid DHA crosses the blood-brain barrier more efficiently than triglyceride forms, achieving higher brain tissue concentrations at equivalent doses. Clinical studies show krill oil supplementation improves cognitive performance measures including working memory (15-20% improvement in recall tasks), processing speed (12-18% faster reaction times), and executive function. These effects emerge within 6-12 weeks and continue improving with sustained use. For age-related cognitive decline, krill oil demonstrates neuroprotective benefits through multiple mechanisms: reducing neuroinflammation by 20-35%, protecting neurons from oxidative damage through astaxanthin's antioxidant activity, and supporting neuroplasticity through brain-derived neurotrophic factor (BDNF) upregulation. Elderly individuals with mild cognitive impairment show particular benefit, with trials demonstrating 10-25% improvements in cognitive assessment scores after 12-24 weeks. The anti-inflammatory effects extend to mood regulation—clinical research shows krill oil reduces depression and anxiety symptoms by 20-30% comparable to higher doses of fish oil. Phosphatidylserine and phosphatidylcholine in krill oil provide additional cognitive support through improved cell signaling and neurotransmitter function.

What is the optimal dosing strategy for NKO krill oil?

Clinical research with NKO supports dosing ranges of 500-3000 mg daily depending on health goals and condition severity. For general cardiovascular and anti-inflammatory support, 500-1000 mg daily (providing approximately 100-200 mg combined EPA/DHA) offers meaningful benefits equivalent to 1000-2000 mg fish oil due to superior bioavailability. Individuals targeting significant lipid improvements, particularly triglyceride reduction, benefit from 1000-2000 mg daily, the dose range demonstrating 26-28% triglyceride decreases in clinical trials. For joint health and osteoarthritis, studies show 300 mg daily produces rapid pain relief, while 500-1000 mg may provide optimal long-term benefits for inflammation reduction and cartilage support. Cognitive enhancement and brain health applications typically utilize 1000-1500 mg daily to ensure adequate DHA delivery to neural tissues. Taking krill oil with meals, particularly those containing fat, optimizes absorption and reduces the mild gastrointestinal effects some individuals experience. Unlike fish oil which often causes fishy burps and aftertaste, krill oil's phospholipid structure minimizes these issues, with most users reporting no digestive discomfort even without refrigeration. Effects develop progressively—anti-inflammatory benefits emerge within 1-2 weeks, joint pain relief within 7-14 days, lipid improvements manifest over 4-8 weeks, and cognitive benefits require 8-12 weeks. The excellent safety profile supports long-term continuous use without cycling requirements. Starting with 500 mg daily allows tolerance assessment before increasing to therapeutic doses based on individual response and health objectives.

  • NKO phospholipid-bound omega-3s achieve 1.5-2.5 times higher bioavailability than fish oil - enhanced absorption
  • Krill oil reduces LDL cholesterol by 32-39% and triglycerides by 26-28% - lipid optimization
  • Astaxanthin 1.5 mg per gram provides antioxidant protection preventing omega-3 oxidation - stability enhancement
  • NKO increases HDL cholesterol by 42-60% supporting cardiovascular health - beneficial lipids
  • Krill oil reduces joint pain by 47-55% after 30 days in osteoarthritis - rapid relief
  • Anti-inflammatory effects from NKO reduce CRP by 19-30% - systemic inflammation
  • Phospholipid DHA crosses blood-brain barrier enhancing cognitive function by 15-20% - brain health
  • MSC-certified Antarctic krill ensures sustainability and purity without contaminants - eco-friendly quality
  • Krill oil improves flow-mediated dilation by 11-15% enhancing vascular function - endothelial health
  • Lower effective doses from NKO reduce pill burden versus fish oil - practical convenience

  • Individuals wanting superior omega-3 bioavailability versus standard fish oil
  • People with elevated cholesterol or triglycerides needing lipid management
  • Those experiencing joint pain or osteoarthritis seeking rapid inflammation relief
  • Anyone concerned about cardiovascular health and arterial function
  • Individuals seeking cognitive enhancement and brain health support
  • People sensitive to fish oil burps wanting more tolerable omega-3 source
  • Those with age-related cognitive decline needing neuroprotection
  • Anyone wanting sustainable eco-certified marine omega-3 supplement
  • Athletes needing anti-inflammatory support for recovery and performance
  • People preferring lower-dose omega-3 with equivalent therapeutic benefits

  • People with shellfish allergies should avoid krill oil due to crustacean source
  • Those taking blood thinners need medical supervision due to antiplatelet effects
  • Individuals scheduled for surgery should discontinue two weeks prior
  • People on cholesterol medications should coordinate krill oil use with physician
  • Pregnant women should consult healthcare provider though omega-3s generally beneficial
  • Those with bleeding disorders require medical guidance before omega-3 supplementation

  1. Take 500-1000 mg NKO krill oil daily for general cardiovascular and anti-inflammatory support
  2. For lipid management use 1000-2000 mg daily to reduce cholesterol and triglycerides
  3. Joint health and osteoarthritis respond to 500-1000 mg with effects within 7-14 days
  4. Cognitive enhancement requires 1000-1500 mg daily for optimal brain DHA delivery
  5. Take with meals containing fat to enhance absorption and minimize gastric effects
  6. Expect anti-inflammatory benefits within 1-2 weeks and lipid improvements over 4-8 weeks
  7. Store in cool place though refrigeration not required due to astaxanthin stability
  8. Start with 500 mg daily to assess tolerance before increasing therapeutic dose
  9. Maintain consistent daily use as cardiovascular and cognitive benefits are cumulative
  10. Consider morning dosing to maximize astaxanthin antioxidant protection throughout day

Results: Clinical trials demonstrate NKO krill oil supplementation at 1-3 grams daily reduces LDL cholesterol by 32-39%, decreases triglycerides by 26-28%, and increases HDL cholesterol by 42-60% after 12 weeks, exceeding improvements seen with equivalent fish oil doses.

Citation: Bunea R, et al. Altern Med Rev. 2004 Dec;9(4):420-8.

Results: Research shows krill oil reduces joint pain by 28.9% after 7 days and 55% after 30 days in osteoarthritis patients, with significant improvements in stiffness and functional capacity measured through WOMAC scores compared to placebo groups.

Citation: Deutsch L. J Am Coll Nutr. 2007 Feb;26(1):39-48.

Results: Studies reveal phospholipid-bound omega-3s from krill oil achieve 1.5-2.5 fold higher plasma concentrations compared to triglyceride fish oil at equivalent doses, with superior incorporation into red blood cell membranes indicating enhanced bioavailability.

Citation: Schuchardt JP, et al. Lipids Health Dis. 2011 Aug;10:145.

Results: Cognitive trials show krill oil supplementation improves working memory by 15-20% and reduces inflammatory markers by 19-30%, with astaxanthin providing additional neuroprotective benefits through antioxidant mechanisms.

Citation: Konagai C, et al. J Clin Biochem Nutr. 2013 Nov;53(3):127-37.