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Science-based food supplements
Manufacturer: Life Extension
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Forskolin 10 mg
60 vegetarian capsules
Item Catalog Number: 01544
Forskolin, a compound extracted from Coleus forskohlii, helps activate an enzyme that increases cAMP, which is crucial for healthy cellular function. Activating cAMP has been shown to help maintain cellular signaling, healthy cell energy, promote cardiovascular health, metabolism, healthy skin cell division and more.
Benefits at a Glance:
Maintaining healthy levels and function of cAMP promotes cardiovascular and metabolic health, encourages healthy cell division in skin and other tissues and may help maintain a healthy weight.*4-7
In clinical and laboratory research, forskolin has been shown to support cardiac muscle strength, normal blood vessel dilation and healthy cerebral blood flow.7-10
Extracts of Coleus forskohlii have also been found to support healthy fat metabolism and body composition, support normal immune activity in skin and stabilize airway openness.7,11,12
Serving Size 1 vegetarian capsule
| Amount Per Serving: | |
|---|---|
| Coleus forskohlii extract (root) [standardized to 10% forskolin (10 mg)] | 100 mg |
| Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), maltodextrin, vegetable stearate. | |
Non-GMO
Dosage and Use
Take one (1) capsule daily on an empty stomach, or as recommended by a healthcare practitioner.
Warnings
KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Forskolin is a bioactive compound extracted from the root of Coleus forskohlii, a plant traditionally used in Ayurvedic medicine. It works primarily by activating the enzyme adenylyl cyclase, which increases cellular levels of cyclic AMP (cAMP), a crucial messenger molecule involved in numerous cellular processes. Elevated cAMP levels trigger a cascade of beneficial metabolic effects including enhanced fat breakdown, increased metabolic rate, and improved cellular function. This unique mechanism makes forskolin distinct from other weight management supplements, as it works at the cellular level to support healthy body composition and metabolic function.
Forskolin supports weight management through multiple mechanisms. By increasing cAMP levels, it activates hormone-sensitive lipase, an enzyme that breaks down stored fat (lipolysis). This promotes the release of fatty acids from fat cells to be used for energy. Forskolin also supports thermogenesis, the body's heat production process that burns calories. Clinical studies show forskolin helps maintain lean body mass while supporting healthy fat metabolism, making it valuable for body composition goals. Additionally, forskolin may support healthy thyroid function, which plays a crucial role in metabolic rate and energy expenditure throughout the day.
Beyond weight management, forskolin offers several health benefits. It supports cardiovascular health by promoting healthy blood pressure already within normal range and supporting proper heart muscle function. Forskolin may support respiratory health by relaxing smooth muscle in airways. The compound supports eye health by helping maintain healthy intraocular pressure. Through cAMP elevation, forskolin supports cellular energy production and mitochondrial function. Some research suggests it may support cognitive function and memory. Forskolin also exhibits antioxidant properties, protecting cells from oxidative stress. These diverse benefits stem from cAMP's role as a master regulator of cellular function.
Results from forskolin supplementation vary by individual but clinical studies provide guidance. For weight management, research shows modest but consistent improvements in body composition over 8-12 weeks when combined with diet and exercise. Some users report increased energy and improved workout performance within 2-4 weeks. Cardiovascular benefits may manifest as improved exercise tolerance and cardiovascular comfort. The 10 mg dose with standardized 20% forskolin content (providing 2 mg active forskolin) matches amounts used in successful clinical trials. For best results, combine forskolin with a balanced diet, regular exercise, and healthy lifestyle habits. Patience is important as metabolic changes develop gradually over several weeks.
For optimal results, take one 10 mg capsule twice daily, preferably with meals to enhance absorption and minimize potential stomach upset. Most clinical studies used divided doses (morning and afternoon/evening) rather than a single large dose, as this maintains more stable cAMP levels throughout the day. Take consistently at the same times daily for at least 8-12 weeks to assess effectiveness, as metabolic changes require time. Combine forskolin supplementation with regular physical activity and a calorie-appropriate diet for best body composition results. Stay well-hydrated and monitor your body's response. If taking medications, particularly for blood pressure or diabetes, consult your healthcare provider about appropriate timing and monitoring.
Results: Clinical trials demonstrate forskolin supplementation supports favorable body composition changes, with studies showing significant decreases in body fat percentage and maintenance of lean body mass compared to placebo groups over 12 weeks in overweight men.
Citation: Godard MP, et al. Obes Res. 2005 Aug;13(8):1335-43.
Results: Research shows forskolin increases cellular cAMP levels by activating adenylyl cyclase, leading to enhanced lipolysis and fat breakdown, with in vitro studies demonstrating 300-400% increases in cAMP concentrations in adipocytes.
Citation: Litosch I, et al. J Cyclic Nucleotide Res. 1982;8(6):393-404.
Results: Studies indicate forskolin supports cardiovascular function including healthy blood pressure and cardiac muscle contractility, with clinical research showing improvements in cardiovascular parameters without adverse effects on heart rate in controlled trials.
Citation: Jagtap M, et al. Indian J Physiol Pharmacol. 2011 Jan-Mar;55(1):52-9.
Results: Clinical research demonstrates forskolin may help maintain healthy intraocular pressure in the eyes, with studies showing significant reductions in elevated intraocular pressure in glaucoma patients supplementing with forskolin.
Citation: Caprioli J, Sears M. Lancet. 1983 Apr;1(8331):958-60.