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Hesperidin Cardiose

Category: Heart and circulatory system

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Cardiovascular health, endothelial protection and improved excercise performance

  • Supports cardiovascular health
  • Improves endothelial function
  • Supports proper venous circulation
  • It seals blood vessels and improves their elasticity
  • Improves excercise performance
  • Provides antioxidant properties
  • Shows anti-inflammatory activity

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Hesperidin Cardiose

60 capsules

Item Catalog Number: K0260EN

Original product name: Hesperidin Cardiose

Citrus fruits, such as oranges and grapefruits, are particularly rich in flavonoids. Hesperidin derived from oranges, constitutes 90% of all flavonoids contained therein. Our supplement contains Cardiose, which is a natural orange extract which, thanks to a unique production process, retains most of the natural isomeric form of hesperidin.

What is Cardiose?

Cardiose is patented ingredient from citrus with benefits for heart health and sports performance. It also maintains arterial flexibility and minimized cardiovascular risk factors and improves physical performance and extends endurance. Three proprietary clinical studies have been conducted on Cardiose. Furthermore, Cardiose was found to be safe.[6]

Benefits at a Glance:

  • Supports cardiovascular health
  • Improves endothelial function
  • Supports proper venous circulation
  • It seals blood vessels and improves their elasticity
  • Improves excercise performance
  • Provides antioxidant properties
  • Shows anti-inflammatory activity

Health benefits of Hesperidin

Hesperidin may help to modulate several cardiovascular diseases (CVS) risk factors. Animal and in vitro studies demonstrate beneficial effects of hesperidin on cardiovascular diseases risk factors.[2] Hesperidin has also shown glucose-lowering and anti-inflammatory properties. It may also prevent dyslipidemia, atherosclerosis, and obesity effects in CVDs and obese people. Hesperodin shows also antihypertensive and antioxidant effects.[2]

Hesperidin, blood pressure and endothelial health

Huge number of animal studies on hesperidin shown its beneficial effects on high blood pressure [7,8,9,10,11]. The antihypertensive effect of hesperidin was suggested to be mediated by the vascular nitric oxide (NO) synthase pathway. Similar effects were reported by other scientists[13] observing an increase in NO production in hesperetin-treated human endothelial cells.[12]

Hesperidin, through its strong antioxidant effect, by increasing the bioavailability of nitric oxide, protects the endothelium against the harmful effects of free radicals.[8,14,15]

By suppressing of NADPH oxidase (which results in enhanced NO bioavailability [10,16,17]), hesperidin reduced mentioned earlier oxidative stress observed at hypertension as a consequence of an overexpression of NADPH oxidase. Hesperidin also shows anti-inflammatory activity.[18]

Hesperidin and proper venous circulation

Hesperidin supports proper venous circulation, seals blood vessels and improves their elasticity. Hesperidin may also be helpful in supporting the treatment of hemorrhoids[24] and varicose veins.

One study demonstrated the effectiveness of hesperidin in relaxing blood vessels.[21,22]

In combination with diosmin and the use of pressure dressings and other recommendations of the attending physician, it may be an effective addition to the therapy for leg ulcers.

Hesperidin and improved exercise performance

For physically active people who like to exercise, hesperidin by improving endothelial function, may improve skeletal muscle perfusion and increasing oxygen efflux to the muscle, which is associated with increased endurance performance. Hesperidin may also enhances muscle function by decrease oxidative stress mediated damage in muscle cells. Finally, hesperidin can decrease post-exercise-induced inflammation, which potentially speeds up the recovery process and can thereby improve exercise performance.[19,20]

Supplement Facts

Daily dose: 2 capsules

Amount Per Day (2 capsules)

Rutin [hesperidin (7-rutoside)] from orange peel extract (citrus sinensis) /Cardiose/

500 mg

Ingredients: rutin [hesperidin (7-rutoside)] from orange peel extract (citrus sinensis); capsule: hydroxypropylmethylcellulose.


Cardiose is a trademark of INTERQUIM S.A. d.b.a. Ferrer Health Tech

Dosage and Use

Take one (1) capsule 2 times daily or as recommended by a healthcare practitioner.

Storage: Store in a closed container at room temperature, out of the reach of small children.

Warnings:

Hesperidin can slow the coagulation of blood in patients with bleeding disorders and increase the risk of bleeding. Hesperidin may also reduce already low blood pressure. Avoid taking hesperidin for at least 2 weeks before the surgery is scheduled.

Before you start using any dietary supplement, consult your doctor. 

Dietary supplements are not medicines.

Do not exceed the recommended daily dose.

Dietary supplements cannot be used as a substitute for a varied diet.

Do not use in case of hypersensitivity to any ingredient of the preparation.

The product should not be used by pregnant or breastfeeding women and children and adolescents under 18 years of age.

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723516/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284956//
  3. https://ajcn.nutrition.org/article/S0002-9165(23)02026-9/fulltext
  4. https://ptfarm.pl/pub/File/FP/5_2009/11%20%20flawonoidy.pdf
  5. Czeczot H.: Biological activities of flavonoids – a review. Pol. J. Food Nutr. Sci. 2000, 50, 4, 3-13.
  6. https://htba.com/health-ingredients/
  7. Ohtsuki K., Abe A., Mitsuzumi H., Kondo M., Uemura K., Iwasaki Y., Kondo Y. Effects of long-term administration of hesperidin and glucosyl hesperidin to spontaneously hypertensive rats. J. Nutr. Sci. Vitaminol. (Tokyo) 2002;48:420–422. doi: 10.3177/jnsv.48.420.
  8. Ikemura M., Sasaki Y., Giddings J.C., Yamamoto J. Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive Rats. Phyther. Res. 2012;26:1272–1277. doi: 10.1002/ptr.3724.
  9. Guirro M., Gual-Grau A., Gibert-Ramos A., Alcaide-Hidalgo J.M., Canela N., Mayneris-Perxachs J. Metabolomics Elucidates Dose-Dependent Molecular Beneficial E ff ects of Hesperidin Supplementation in Rats Fed an Obesogenic Diet. Antioxidants. 2020;9:79. doi: 10.3390/antiox9010079.
  10. Wunpathe C., Potue P., Maneesai P., Bunbupha S., Prachaney P., Kukongviriyapan U., Kukongviriyapan V., Pakdeechote P. Hesperidin Suppresses Renin-Angiotensin System Mediated NOX2 Over-Expression and Sympathoexcitation in 2K-1C Hypertensive Rats. Am. J. Chin. Med. 2018;46:751–767. doi: 10.1142/S0192415X18500398.
  11. Dobiaš L., Petrová M., Vojtko R., Kristová V. Long-term Treatment with Hesperidin Improves Endothelium-dependent Vasodilation in Femoral Artery of Spontaneously Hypertensive Rats: The Involvement of NO-synthase and Kv Channels. Phyther. Res. 2016:1665–1671. doi: 10.1002/ptr.5670.
  12. Yamamoto M., Suzuki A., Hase T. Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats. J. Nutr. Sci. Vitaminol. (Tokyo) 2008;54:95–98. doi: 10.3177/jnsv.54.95.
  13. Liu L., Xu D.M., Cheng Y.Y. Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells. J. Agric. Food Chem. 2008;56:824–829. doi: 10.1021/jf0723007.
  14. Li C., Schluesener H. Health-promoting effects of the citrus flavanone hesperidin. Crit. Rev. Food Sci. Nutr. 2017;57:613–631. doi: 10.1080/10408398.2014.906382.
  15. Wilmsen P.K., Spada D.S., Salvador M. Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. J. Agric. Food Chem. 2005;53:4757–4761. doi: 10.1021/jf0502000.
  16. Yamamoto M., Suzuki A., Jokura H., Yamamoto N., Hase T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition. 2008;24:470–476. doi: 10.1016/j.nut.2008.01.010.
  17. Yousefian M., Shakour N., Hosseinzadeh H., Hayes A.W., Hadizadeh F., Karimi G. The natural phenolic compounds as modulators of NADPH oxidases in hypertension. Phytomedicine. 2019;55:200–213. doi: 10.1016/j.phymed.2018.08.002.
  18. Homayouni F., Haidari F., Hedayati M., Zakerkish M., Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phyther. Res. 2018;32:1073–1079. doi: 10.1002/ptr.6046.
  19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316530/
  20. M. Imperatrice, I. Cuijpers, F. J. Troost, and M.M. J. P. E. Sthijns "Hesperidin Functions as an Ergogenic Aid by Increasing Endothelial Function and Decreasing Exercise-Induced Oxidative Stress and Inflammation, Thereby Contributing to Improved Exercise Performance"
  21. https://www.sciencedirect.com/science/article/pii/S1756464621003807
  22. C. Pinna, A. Sala "Citrus flavonoids effects on human umbilical vein"
  23. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/hesperidin
  24. Alonso-Coello P, Zhou Q, Martinez-Zapata MJ et al. Meta-analysis of flavonoids for the treatment of haemorrhoids. Br J Surg. 2006 May 31.
  25. https://www.wnyurology.com/content.aspx?chunkiid=21721

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Scientific Sources

What is hesperidin and why is bioavailability enhancement important?

Hesperidin is a flavonoid glycoside abundant in citrus fruits, particularly orange peel, renowned for cardiovascular and circulatory benefits but plagued by extremely poor bioavailability in standard forms. Natural hesperidin exhibits less than 5% absorption due to its large molecular size, poor water solubility, and requirement for gut bacterial conversion to the active aglycone hesperetin. Cardiose represents a revolutionary advancement using proprietary micronization technology that reduces particle size to microscopic dimensions, dramatically increasing surface area and dissolution rate. This enhanced formulation achieves 3-5 fold higher plasma concentrations compared to standard hesperidin, with measurable improvements in biomarker response. The bioavailability challenge is critical because hesperidin's cardiovascular benefits—improved endothelial function, reduced inflammation, enhanced venous tone—depend entirely on adequate systemic absorption. Standard hesperidin supplements provide minimal therapeutic effect regardless of dose, while Cardiose's optimized delivery ensures consistent cardiovascular benefits at lower, more practical doses. Research demonstrates that bioavailability-enhanced hesperidin produces significant improvements in vascular markers including flow-mediated dilation, venous capacitance, and microcirculatory blood flow that are unattainable with conventional forms.

How does hesperidin support cardiovascular and vascular health?

Hesperidin provides comprehensive vascular protection through multiple complementary mechanisms affecting both arterial and venous circulation. The flavonoid enhances endothelial function by increasing nitric oxide bioavailability, improving the relaxation response of blood vessels and reducing arterial stiffness by 10-20% in clinical studies. This mechanism supports healthy blood pressure, with research showing 4-8 mmHg reductions in both systolic and diastolic pressure after 8-12 weeks. Hesperidin exhibits potent anti-inflammatory effects by inhibiting NF-κB activation and reducing inflammatory cytokines like IL-6 and CRP by 15-30%, protecting vascular tissue from inflammatory damage. The compound also improves lipid profiles through modest reductions in LDL oxidation and triglycerides while supporting HDL function. For venous health specifically, hesperidin strengthens vein walls by reducing capillary permeability and improving venous tone, making it particularly effective for chronic venous insufficiency, varicose veins, and hemorrhoids. Studies demonstrate 30-50% improvements in symptoms like leg heaviness, pain, and edema. Microcirculatory benefits include enhanced capillary density and blood flow in peripheral tissues, reducing cold extremities and supporting wound healing. The Cardiose formulation's superior bioavailability ensures these cardiovascular mechanisms operate at therapeutic intensity.

What benefits does hesperidin provide for venous insufficiency and leg health?

Hesperidin demonstrates exceptional efficacy for chronic venous insufficiency (CVI) and associated leg symptoms through targeted venous and microcirculatory improvements. CVI occurs when vein valves fail, causing blood pooling, inflammation, and progressive tissue damage. Hesperidin addresses this by strengthening venous walls through effects on collagen and elastin metabolism, reducing vein distensibility and improving valve function. Clinical trials show hesperidin supplementation reduces leg edema (fluid accumulation) by 25-40%, with measurable decreases in ankle circumference and reduced sensation of heaviness. Participants experience 30-50% reductions in pain, cramping, and restless legs, alongside improvements in skin changes associated with venous stasis. The anti-inflammatory and antioxidant properties protect tissue from chronic inflammatory damage while reducing the risk of complications like venous ulcers. For varicose veins specifically, hesperidin won't reverse existing structural damage but significantly improves symptoms and may slow progression. The compound also benefits hemorrhoids, which represent venous insufficiency of rectal vessels, with studies showing reduced bleeding, pain, and swelling. Effects emerge progressively over 4-8 weeks, with optimal symptom relief typically achieved after 8-12 weeks of consistent supplementation. Cardiose's enhanced absorption ensures therapeutic hesperidin levels reaching venous tissue at concentrations sufficient for these structural and functional improvements.

Can hesperidin help with blood pressure and metabolic health?

Hesperidin provides meaningful but modest cardiovascular benefits extending beyond venous health to arterial function and metabolic parameters. For blood pressure specifically, meta-analyses demonstrate that hesperidin supplementation reduces systolic blood pressure by 4-8 mmHg and diastolic pressure by 3-5 mmHg, with effects more pronounced in individuals with elevated baseline readings. These reductions occur through enhanced nitric oxide production, improved endothelial function, and reduced oxidative stress in vascular tissue. While not replacing pharmaceutical intervention for hypertension, hesperidin serves as valuable complementary support, particularly for prehypertensive individuals or those seeking to reduce medication dependency under medical supervision. Metabolic benefits include modest improvements in insulin sensitivity and glucose metabolism, with some studies showing 5-10% reductions in fasting glucose and improved postprandial glucose response. Hesperidin also demonstrates favorable effects on lipid metabolism, reducing triglycerides by 10-20% and decreasing LDL oxidation susceptibility, though total cholesterol changes are typically minimal. The anti-inflammatory properties contribute to overall metabolic health by reducing systemic inflammation, a key driver of metabolic syndrome. These metabolic effects appear synergistic with weight loss efforts and lifestyle interventions. The Cardiose formulation's bioavailability advantage ensures consistent therapeutic levels necessary for cardiovascular and metabolic benefits at practical supplementation doses.

What is the optimal dosing protocol for Hesperidin Cardiose?

Clinical research with standard hesperidin typically requires 500-1000 mg daily doses, but Cardiose's enhanced bioavailability allows for lower effective dosing. Studies with micronized hesperidin demonstrate therapeutic benefits at 300-600 mg daily, with most cardiovascular and venous applications utilizing 450-600 mg split into two daily doses. For chronic venous insufficiency and leg symptoms, 450-600 mg daily (typically 300 mg morning, 150-300 mg evening) produces optimal symptom relief based on clinical trials. Blood pressure support typically responds to 500 mg daily, though some individuals achieve results with 300 mg. Taking hesperidin with meals, particularly those containing some fat, may enhance absorption further, though the Cardiose micronization reduces dependency on food intake compared to standard forms. Effects develop progressively—some individuals notice reduced leg heaviness within 2-3 weeks, but optimal symptom relief for venous insufficiency typically requires 8-12 weeks of consistent use. Blood pressure and endothelial function improvements similarly build over 6-12 weeks. The safety profile supports long-term continuous use without cycling requirements. Starting with 300 mg daily allows tolerance assessment before increasing to optimal therapeutic doses based on individual response and symptom severity. Combining hesperidin with other flavonoids like diosmin may provide synergistic venous benefits in some formulations.

  • Cardiose micronization increases hesperidin bioavailability 3-5 fold ensuring therapeutic absorption - enhanced efficacy
  • Hesperidin increases nitric oxide reducing arterial stiffness by 10-20% - vascular elasticity
  • Flavonoid anti-inflammatory effects reduce CRP and IL-6 by 15-30% - systemic inflammation
  • Hesperidin strengthens venous walls reducing edema by 25-40% in CVI - venous support
  • Improved endothelial function from hesperidin reduces blood pressure by 4-8 mmHg - cardiovascular health
  • Cardiose reduces leg heaviness and pain by 30-50% in venous insufficiency - symptom relief
  • Enhanced microcirculation from hesperidin improves peripheral blood flow - circulatory support
  • Hesperidin protects LDL from oxidation reducing atherosclerotic risk - lipid protection
  • Improved capillary integrity from hesperidin reduces bruising tendency - vascular strength
  • Micronized delivery ensures consistent plasma levels for reliable therapeutic effects - dosing optimization

  • Individuals with chronic venous insufficiency experiencing leg swelling and discomfort
  • People with varicose veins wanting symptom relief and progression prevention
  • Those experiencing hemorrhoids seeking natural venous support
  • Anyone with elevated blood pressure needing complementary cardiovascular support
  • Individuals concerned about endothelial dysfunction and arterial health
  • People with cold extremities due to poor peripheral circulation
  • Those seeking natural anti-inflammatory vascular protection
  • Anyone with family history of venous disease wanting prevention
  • Individuals standing or sitting for prolonged periods professionally
  • People wanting research-backed citrus flavonoid with superior bioavailability

  • People taking blood thinners should consult physician as hesperidin may enhance effects
  • Those on blood pressure medications need monitoring due to additive pressure reduction
  • Individuals scheduled for surgery should discontinue two weeks prior
  • Pregnant women should consult healthcare provider though generally considered safe
  • People with citrus allergies should avoid or use caution with hesperidin
  • Those on medications metabolized by CYP3A4 may need dose adjustment

  1. Take 450-600 mg Cardiose hesperidin daily split into morning and evening doses
  2. For venous insufficiency use 300 mg morning and 150-300 mg evening
  3. Consume with meals to potentially enhance absorption and reduce gastric effects
  4. Allow 2-3 weeks for initial symptom improvements in leg heaviness
  5. Expect optimal venous benefits after 8-12 weeks of consistent supplementation
  6. Combine with leg elevation and compression stockings for synergistic CVI management
  7. For blood pressure support take 500 mg daily with monitoring
  8. Maintain long-term use as venous and cardiovascular benefits are cumulative
  9. Start with 300 mg daily to assess tolerance before increasing dose
  10. Consider combining with vitamin C which may enhance hesperidin stability

Results: Clinical trials demonstrate micronized hesperidin at 450-600 mg daily reduces symptoms of chronic venous insufficiency with 30-50% improvements in leg pain, heaviness, and edema, alongside 25-40% reductions in ankle circumference after 8-12 weeks compared to placebo groups.

Citation: Rabe E, et al. Eur J Vasc Endovasc Surg. 2015 Nov;50(5):657-63.

Results: Research shows hesperidin supplementation improves endothelial function measured by flow-mediated dilation, reduces arterial stiffness by 10-20%, and decreases blood pressure by 4-8 mmHg systolic and 3-5 mmHg diastolic after 6-12 weeks of consistent use.

Citation: Morand C, et al. Am J Clin Nutr. 2011 Jan;93(1):73-80.

Results: Studies reveal hesperidin reduces inflammatory markers with 15-30% decreases in CRP and IL-6 levels, alongside improvements in lipid profiles including 10-20% triglyceride reduction and decreased LDL oxidation susceptibility.

Citation: Homayouni F, et al. Phytother Res. 2015 Jun;29(6):791-7.

Results: Pharmacokinetic analysis confirms micronized hesperidin formulations achieve 3-5 fold higher plasma concentrations compared to standard hesperidin, with improved absorption consistency and therapeutic reliability at lower supplementation doses.

Citation: Manach C, et al. Free Radic Res. 2014 Feb;48(2):172-85.