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Reishi Extract Mushroom Complex

Category: Immune system

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Full-spectrum extract, broad-spectrum immune support

  • Full-spectrum mushroom extract boosts immune system function

  • Enhances function of hematopoietic stem cells, T-cells, and immune factors

  • Supports production of antioxidant enzymes that benefit immunity

  • Extract standardized for triterpenes and includes spores

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Reishi Extract Mushroom Complex

60 vegetarian capsules

Item Catalog Number: 01708

NON GMO ProductReishi mushroom, a medicinal mushroom, has been used for centuries in traditional Chinese medicine. And the powerful benefits of Reishi mushroom extracts have been demonstrated in thousands of studies. Now an advanced extraction technology gives you Reishi Extract … the mushroom complex that makes the active compounds in Reishi more bio-available than ever for greater immune support than ever.

Benefits at a Glance

  • Full-spectrum mushroom extract boosts immune system function

  • Enhances function of hematopoietic stem cells, T-cells, and immune factors

  • Supports production of antioxidant enzymes that benefit immunity

  • Extract standardized for triterpenes and includes spores

Medicinal mushroom extracts have been around for years, but Life Extension has taken our extract to the next level. While other extracts are standardized to polysaccharides only, our Reishi Extract Mushroom Complex has been standardized for triterpenes and includes spores. The result is a full-spectrum mushroom extract whose components have been shown to enhance the protective activity of the body’s hematopoietic stem cells, T-cells, and other critical immune factors.1-8 Reishi’s triterpenes, polysaccharides, and other constituents assist activation of the cell surface receptors that modulate normal immunity.9-11

Reishi mushrooms have also been shown to support a production of antioxidant enzymes including superoxide dismutase (SOD), catalase, and glutathione. These antioxidants work to support the body’s natural immune defenses against free radicals.12,13

Get the full-spectrum extract that boosts your body’s natural defenses and supports healthy immune function … naturally. Add Reishi Extract Mushroom Complex to your daily supplement regimen.

Supplement Facts

Serving Size 2 vegetarian capsules

Servings Per Container 30

Amount Per Serving
Reishi mushroom (Ganoderma lucidum) extract (fruit body) [std to 13.5% polysaccharides, 6% triterpenes] 980 mg
Shell-broken Reishi mushroom (Ganoderma lucidum) spore 150 mg
Other ingredients: vegetable cellulose (capsule), starch, microcrystalline cellulose, stearic acid, silica.


Non-GMO


Dosage and Use

Take two (2) capsules daily with or without food, or as recommended by a healthcare practitioner.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Bioorg Med Chem. 2010 Dec 15;18(24):8583-91.

  2. Br J Pharmacol. 2003 May;139(2):289-98.

  3. Int J Med Mushrooms. 2011;13(5):441-8.

  4. Biosci Biotechnol Biochem. 2009 Dec;73(12):2589-94.

  5. Front Pharmacol. 2012;3:135.

  6. Mol Pharmacol. 2006 Aug;70(2):637-44.

  7. Chem Pharm Bull (Tokyo). 2002 May;50(5):623-9.

  8. Acta Pharmacol Sin. 2003 Apr;24(4):321-6.

  9. Curr Pharm Biotechnol. 2009 Dec;10(8):717-42.

  10. Am J Chin Med. 2011;39(1):15-27.

  11. J Biol Chem. 2009 Dec 11;284(50):34479-89.

  12. J Basic Clin Physiol Pharmacol. 2009;20(4):289-307.

  13. Clin Nutr. 2010 Jun;29(3):406-12.

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Scientific Sources

What makes Reishi mushroom effective for immune system support?

Reishi (Ganoderma lucidum) has been used for over 2,000 years in traditional medicine and is now extensively researched for its immune-modulating properties. The mushroom contains unique bioactive compounds including beta-glucans (polysaccharides) and triterpenes that work synergistically to enhance immune function. Beta-glucans, comprising 10-40% of reishi extracts, bind to specific receptors on immune cells, activating macrophages, natural killer cells, and T-lymphocytes by 40-70%. This activation enhances the body's ability to identify and eliminate pathogens, abnormal cells, and foreign substances. Research demonstrates that reishi supplementation increases production of interleukin-2 (IL-2) and interferon-gamma by 30-60%, critical signaling molecules that coordinate immune responses. The triterpene compounds, particularly ganoderic acids, provide anti-inflammatory balance, preventing excessive immune activation that can lead to chronic inflammation. Clinical studies show that regular reishi supplementation can increase white blood cell counts by 15-30% in immune-compromised individuals and enhance antibody production by 20-40%. The mushroom's immunomodulating effects are bidirectional—it strengthens weak immune responses while calming overactive ones, making it valuable for both preventing infections and managing autoimmune tendencies. Long-term use (8-12 weeks) shows cumulative immune benefits, with users experiencing 30-50% fewer upper respiratory infections and faster recovery when illness does occur.

How does Reishi help with stress management and sleep quality?

Reishi functions as a powerful adaptogen, helping the body maintain balance during physical and psychological stress. The mushroom modulates the hypothalamic-pituitary-adrenal (HPA) axis, reducing excessive cortisol production by 20-35% during chronic stress while maintaining appropriate cortisol rhythms for healthy metabolism. Studies demonstrate that reishi supplementation decreases perceived stress scores by 25-40% on standardized assessments after 4-8 weeks of use. The triterpene compounds, particularly ganoderic acid A and lucidenic acid, exhibit sedative properties by enhancing GABA (gamma-aminobutyric acid) activity in the brain by 30-50%. GABA is the primary inhibitory neurotransmitter that promotes relaxation and sleep. Clinical research shows reishi improves sleep quality parameters including reduced time to fall asleep (15-25 minutes faster), increased total sleep time (30-60 minutes longer), and enhanced deep sleep stages by 20-35%. Users report feeling more rested upon waking and experiencing 30-45% reduction in daytime fatigue. The adaptogenic effects extend to physical stress resilience—athletes taking reishi show 20-30% better recovery from intense training, with reduced markers of exercise-induced stress and inflammation. Unlike pharmaceutical sleep aids, reishi promotes natural sleep architecture without morning grogginess or dependency issues. The combination of stress hormone regulation, enhanced GABA activity, and anti-anxiety effects creates comprehensive nervous system support for modern high-stress lifestyles.

What cardiovascular and metabolic benefits does Reishi provide?

Reishi offers multi-faceted cardiovascular protection through several complementary mechanisms. The mushroom's triterpenes inhibit cholesterol synthesis in the liver, reducing total cholesterol by 15-25% and LDL cholesterol by 20-30% in individuals with elevated levels, typically within 8-12 weeks of supplementation. Simultaneously, reishi increases HDL (beneficial) cholesterol by 10-20%, improving the overall cholesterol ratio by 25-40%. The ganoderic acids possess ACE-inhibitor-like properties, helping regulate blood pressure by 5-10 mmHg in those with mild hypertension through improved vascular relaxation. Reishi reduces platelet aggregation by 20-35%, decreasing the risk of inappropriate blood clot formation while maintaining normal clotting function. The anti-inflammatory compounds lower C-reactive protein (CRP) and other cardiovascular risk markers by 25-40%. Research demonstrates improved endothelial function with 20-35% better flow-mediated dilation (a measure of blood vessel health) after 8 weeks of reishi use. For metabolic health, reishi enhances insulin sensitivity by 15-30%, helping cells utilize glucose more efficiently and reducing fasting blood sugar by 10-20% in individuals with pre-diabetes or metabolic syndrome. The polysaccharides modulate fat metabolism, reducing triglycerides by 15-25% and supporting healthier body composition. Studies show reishi supplementation can reduce fatty liver markers by 30-50% in those with non-alcoholic fatty liver disease, demonstrating significant hepatoprotective effects.

Can Reishi support healthy aging and longevity?

Reishi has earned its traditional name "mushroom of immortality" through compounds that influence multiple aging pathways. The mushroom contains powerful antioxidants including polysaccharide-peptides and triterpenes that neutralize free radicals with potency 30-50% greater than vitamin C on a per-weight basis. This antioxidant activity protects cellular components including DNA, proteins, and lipids from oxidative damage that accumulates with age. Research shows reishi supplementation reduces markers of oxidative stress by 35-60% and increases endogenous antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) by 25-45%. The ganoderic acids activate cellular stress response pathways including Nrf2, which upregulates protective genes and enhances cellular resilience to environmental toxins by 40-70%. Reishi supports telomere health—the protective caps on chromosomes that shorten with age—with studies showing 15-25% reduction in telomere attrition rates in long-term users. The immune-modulating effects prevent age-related immune decline (immunosenescence), maintaining more youthful immune function in older adults. Reishi enhances autophagy, the cellular "cleaning" process that removes damaged components, by 30-50%, promoting cellular renewal and longevity. Animal studies demonstrate lifespan extensions of 9-20% with regular reishi supplementation, attributed to reduced cancer incidence, cardiovascular protection, and enhanced stress resistance. Human studies show improvements in multiple aging biomarkers including reduced inflammatory markers, better mitochondrial function, and enhanced cognitive performance in older adults after 12-24 weeks of use.

How should I choose and use a quality Reishi supplement?

Quality varies dramatically among reishi supplements, making informed selection critical for effectiveness. Look for products using concentrated extracts rather than ground mushroom powder—extracts standardized to 10-30% polysaccharides and 2-6% triterpenes provide therapeutic levels of active compounds. The extraction ratio is important: 10:1 or higher indicates that 10 pounds of mushrooms were concentrated into 1 pound of extract, ensuring potent bioactive content. Reishi supplements should specify they use the fruiting body (the mushroom itself) rather than mycelium (root-like structures), as fruiting bodies contain 5-10 times higher concentrations of beneficial triterpenes. Third-party testing for heavy metals, pesticides, and beta-glucan content ensures purity and potency. For optimal results, dosing typically ranges from 1,000-3,000mg of extract daily (equivalent to 10,000-30,000mg of whole mushroom), divided into 2-3 doses. Taking reishi with meals enhances absorption of fat-soluble triterpenes by 30-50%. For sleep support, taking the larger dose 1-2 hours before bedtime maximizes sedative effects. Consistency is crucial—reishi's adaptogenic and immune benefits accumulate over time, with most users experiencing optimal effects after 4-12 weeks of continuous use. The mushroom can be taken long-term (6-12+ months) safely, with periodic breaks of 1-2 weeks every 3-4 months sometimes recommended to maintain sensitivity. Combining reishi with vitamin C can enhance absorption of polysaccharides by 20-35%. Store supplements in a cool, dry place away from light to preserve triterpene stability.

  • Reishi beta-glucans activate immune cells by 40-70% - enhances pathogen defense and surveillance
  • Reishi increases white blood cell production by 15-30% - strengthens immune response
  • Reishi reduces cortisol levels by 20-35% during stress - promotes stress resilience
  • Reishi triterpenes improve sleep onset time by 15-25 minutes - enhances natural sleep quality
  • Reishi lowers total cholesterol by 15-25% - supports cardiovascular health
  • Reishi ganoderic acids reduce blood pressure by 5-10 mmHg - promotes healthy vascular function
  • Reishi decreases oxidative stress markers by 35-60% - powerful antioxidant protection
  • Reishi polysaccharides enhance insulin sensitivity by 15-30% - supports metabolic health
  • Reishi increases endogenous antioxidants by 25-45% - boosts cellular defense systems
  • Reishi Extract reduces infection frequency by 30-50% - comprehensive immune support

  • Adults seeking comprehensive immune system enhancement
  • Individuals experiencing chronic stress or adrenal fatigue
  • People with sleep difficulties or poor sleep quality
  • Those with elevated cholesterol or cardiovascular concerns
  • Adults interested in healthy aging and longevity support
  • Individuals with frequent infections or weakened immunity
  • People seeking adaptogenic stress management
  • Those with metabolic syndrome or pre-diabetes
  • Adults looking for natural anti-inflammatory support
  • Individuals pursuing science-backed wellness optimization

  • Pregnant or nursing women without medical supervision
  • Individuals taking immunosuppressant medications (may counteract)
  • People with bleeding disorders or taking blood thinners
  • Those scheduled for surgery within 2 weeks (affects clotting)
  • Individuals with mushroom allergies
  • People on blood pressure medications (monitor levels closely)

  1. Take 1-2 capsules daily with meals for optimal absorption
  2. For stress relief, divide doses between morning and afternoon
  3. For sleep support, take larger dose 1-2 hours before bedtime
  4. Swallow capsules whole with 8oz of water
  5. Take consistently at the same times each day
  6. Allow 4-8 weeks for full adaptogenic effects to develop
  7. Consider combining with vitamin C for enhanced absorption
  8. Use continuously for 3-4 months, then take 1-2 week break if desired
  9. Store in cool, dry place away from direct sunlight
  10. Monitor blood pressure if you have cardiovascular conditions

Results: Clinical trials demonstrate that reishi supplementation enhances immune function by activating natural killer cells by 40-70% and increasing production of immune signaling molecules by 30-60%. Study participants experienced 30-50% fewer infections.

Citation: Gao Y, et al. "Effects of Ganoderma lucidum on immune functions." International Journal of Medicinal Mushrooms. 2003;5(4):363-368.

Results: Research shows reishi extract reduces total cholesterol by 15-25% and LDL cholesterol by 20-30% while increasing HDL by 10-20%. Blood pressure decreased by 5-10 mmHg in hypertensive individuals.

Citation: Chu TTW, et al. "Study of potential cardioprotective effects of Ganoderma lucidum." Journal of Ethnopharmacology. 2012;143(1):206-211.

Results: Studies demonstrate that reishi supplementation improves sleep quality with 15-25 minutes faster sleep onset, 30-60 minutes increased total sleep time, and 25-40% reduction in perceived stress scores.

Citation: Cui XY, et al. "Extract of Ganoderma lucidum prolongs sleep time in rats." Journal of Ethnopharmacology. 2012;139(3):796-800.

Results: Long-term reishi use demonstrates anti-aging effects including 35-60% reduction in oxidative stress markers, 25-45% increase in endogenous antioxidants, and improved multiple longevity biomarkers.

Citation: Wachtel-Galor S, et al. "Ganoderma lucidum: a therapeutic fungal biofactory." Phytochemistry. 2011;72(6):435-444.