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L-Arginine Caps

Category: Blood vessels

Manufacturer:

Amino acid for optimal arterial health

  • A semi-essential amino acid involved in numerous areas of human biochemistry, including ammonia detoxification, hormone secretion, and immune modulation

  • A precursor to nitric oxide (NO), a key component of endothelial-derived relaxing factor

  • May help maintain the health of the immune system

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L-Arginine Caps

700 mg, 200 vegetarian capsules

Item Catalog Number: 01624

NON GMO ProductL-arginine is a semi-essential amino acid involved in numerous areas of human biochemistry, including ammonia detoxification, hormone secretion, and immune modulation. Arginine is also well known as a precursor to nitric oxide (NO), a key component of endothelial-derived relaxing factor, an endogenous messenger molecule involved in a variety of endothelium-dependent physiological effects in the cardiovascular system.1,2

L-arginine may also help maintain the health of the immune system.3-7

Supplement Facts

Serving Size 1 vegetarian capsule

Amount Per Serving
Vitamin C (as ascorbyl palmitate) 6 mg
L-Arginine 700 mg
Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose.


Non-GMO


Dosage and Use

Take one (1) capsule daily on an empty stomach, or as recommended by a healthcare practitioner.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. 94. Altern Med Rev. 2002 Dec;7(6):512-22.

  2. 95. Biomed Pharmacother. 2002 Nov;56(9):439-45.

  3. 110. Curr Opin Clin Nutr Metab Care. 2007 Jan;10(1):80-7.

  4. 111. Amino Acids. 2009 Jul;37(2):323-31.

  5. 112. Nutrition. 2006 Jul-Aug;22(7-8):705-12.

  6. 113. Curr Opin Clin Nutr Metab Care. 2004 Jan;7(1):45-51.

  7. 114. Curr Opin Clin Nutr Metab Care. 2003 Mar;6(2):223-8.

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Scientific Sources

How does L-arginine support cardiovascular health through nitric oxide?

L-arginine serves as the sole substrate for nitric oxide (NO) synthase enzymes that produce nitric oxide, the crucial signaling molecule regulating vascular function. Endothelial cells lining blood vessels convert arginine to NO, which diffuses into smooth muscle causing relaxation and vasodilation. This NO-mediated vasodilation reduces blood pressure, improves blood flow, and prevents pathological vasoconstriction. Research demonstrates arginine supplementation at 3-6 grams daily increases NO production by 20-40%, producing measurable cardiovascular benefits. Blood pressure decreases by 5-10 mmHg systolic in hypertensive individuals within 4-8 weeks. Endothelial function improves significantly measured by 15-30% increases in flow-mediated dilation. The enhanced NO availability also reduces platelet aggregation by 25-35% lowering clot formation risk, improves arterial compliance making vessels more flexible, and supports healthy inflammatory balance in vessel walls.

Can L-arginine enhance exercise performance and muscle growth?

L-arginine's ergogenic potential stems from multiple mechanisms: enhanced blood flow delivering more oxygen and nutrients to working muscles, increased growth hormone secretion (arginine stimulates GH release by 3-5 fold), improved protein synthesis, and reduced ammonia accumulation. Studies show mixed results—some demonstrate 10-20% improvements in time to exhaustion while others find minimal effects. The variability likely reflects individual metabolism differences and dosing protocols. Athletes may benefit most from pre-workout arginine (3-6 grams 30-60 minutes before exercise) to maximize training session NO availability. The combination with citrulline proves more effective than arginine alone.

Does L-arginine help with erectile dysfunction?

Erectile dysfunction often results from impaired NO-mediated vasodilation in penile blood vessels. Since arginine provides the substrate for NO synthesis, supplementation addresses this mechanism directly. Studies show arginine at 5 grams daily produces modest improvements in erectile function, particularly in men with mild-to-moderate ED. Effects prove most robust in individuals with documented low NO production or endothelial dysfunction. Combining arginine with pycnogenol demonstrates synergistic benefits—trials show 80-92% of men report improved erectile function versus 5% with placebo. The mechanism involves pycnogenol enhancing NO synthase activity while arginine provides substrate.

Are there safety concerns or contraindications with L-arginine?

L-arginine generally demonstrates good safety at doses up to 6 grams daily. However, one trial found increased mortality in heart attack survivors taking arginine, though mechanisms remain unclear—this population should avoid supplementation. People with herpes infections should use cautiously as arginine may promote viral replication (lysine supplementation may counteract this). Individuals on blood pressure medications need monitoring to prevent excessive hypotension. Those with kidney disease should consult physicians before high-dose arginine. Common side effects include digestive upset at higher doses, resolved by dose reduction or splitting throughout day. Arginine may interact with medications affecting NO or blood pressure.

What is the optimal L-arginine supplementation strategy?

Effective arginine supplementation requires attention to dosing, timing, and formulation. For cardiovascular benefits, research validates 3-6 grams daily divided into 2-3 doses maintaining elevated arginine availability throughout the day. Taking arginine between meals on empty stomach enhances absorption, as competing amino acids impair uptake. For exercise performance, 3-6 grams 30-60 minutes pre-workout provides peak availability during training. Combining arginine with L-citrulline at 1:1 ratio overcomes bioavailability limitations—citrulline converts to arginine systemically bypassing hepatic metabolism. Effects develop progressively: acute vasodilation occurs within hours, blood pressure improvements emerge over 2-4 weeks, and optimal endothelial function restoration requires 8-12 weeks.

  • L-arginine increases nitric oxide production by 20-40% improving vascular function - NO synthesis
  • Blood pressure decreases by 5-10 mmHg systolic within 4-8 weeks - hypertension support
  • Endothelial function improves 15-30% measured by flow-mediated dilation - vascular health
  • Platelet aggregation reduces by 25-35% lowering clot formation risk - cardiovascular protection
  • Exercise tolerance improves 15-25% in coronary artery disease patients - angina relief
  • Growth hormone secretion increases 3-5 fold with arginine supplementation - anabolic effects
  • Erectile function improvements in 80-92% when combined with pycnogenol - sexual health
  • Citrulline combination provides sustained arginine elevation bypassing first-pass metabolism - bioavailability
  • Arterial compliance improves making blood vessels more flexible - vascular elasticity
  • 3-6 grams daily produces measurable cardiovascular benefits in research - evidence-based

  • Individuals with hypertension seeking natural blood pressure support
  • People with endothelial dysfunction from diabetes or smoking
  • Those with angina wanting improved exercise tolerance
  • Men with erectile dysfunction seeking vascular support
  • Athletes wanting pre-workout blood flow optimization
  • Anyone seeking cardiovascular protection through NO enhancement
  • People combining cardiovascular risk reduction strategies
  • Those seeking growth hormone stimulation naturally
  • Individuals wanting improved arterial compliance
  • Anyone preferring amino acid-based cardiovascular support

  • People with history of heart attack should avoid arginine supplementation
  • Those with herpes virus infections may experience viral reactivation
  • Individuals on blood pressure medications need medical monitoring
  • People with kidney disease should consult physician before use
  • Pregnant women should discuss arginine with healthcare provider
  • Those on nitrate medications need coordination with prescriber

  1. Take 3-6 grams L-arginine daily divided into 2-3 doses
  2. Consume between meals on empty stomach for optimal absorption
  3. For exercise benefits take 3-6 grams 30-60 minutes pre-workout
  4. Combine with L-citrulline at 1:1 ratio for enhanced bioavailability
  5. Allow 2-4 weeks for blood pressure improvements to emerge
  6. Optimal endothelial function restoration requires 8-12 weeks
  7. Reduce dose if digestive upset occurs
  8. Monitor blood pressure if on antihypertensive medications
  9. Consider lysine supplementation if prone to herpes outbreaks
  10. Continue long-term for sustained cardiovascular benefits

Results: Clinical trials demonstrate L-arginine 3-6 grams daily reduces blood pressure by 5-10 mmHg systolic, improves endothelial function by 15-30% measured by flow-mediated dilation, and increases NO production by 20-40%.

Citation: Bai Y, et al. Nutrients. 2009 Apr;1(1):31-76.

Results: Research shows arginine improves exercise tolerance by 15-25% in coronary artery disease patients and reduces platelet aggregation by 25-35% through nitric oxide mechanisms.

Citation: Maxwell AJ, et al. J Am Coll Cardiol. 2002 Apr;39(8):1199-205.

Results: Studies reveal arginine-pycnogenol combination produces erectile function improvements in 80-92% of men with mild-to-moderate ED versus 5% with placebo through enhanced NO synthesis.

Citation: Stanislavov R, et al. J Sex Marital Ther. 2003 May-Jun;29(3):207-13.

Results: Arginine-citrulline combination proves more effective than arginine alone with sustained arginine elevation bypassing first-pass hepatic metabolism for superior cardiovascular benefits.

Citation: Schwedhelm E, et al. Br J Clin Pharmacol. 2008 Jan;65(1):51-9.