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Optimized Chromium with Crominex® 3+

Category: Blood sugar

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Maintain healthy glucose metabolism

  • Normal cellular glucose absorption

  • Healthy endothelial function

  • Healthy lipid and triglyceride levels

  • Normal cellular energy production

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Optimized Chromium with Crominex® 3+

500 mcg, 60 vegetarian capsules

Item Catalog Number: 01504

Chromium is a critical micronutrient recognized for its vital role in maintaining healthy glucose metabolism. This most advanced chromium complex has been optimized with a standardized extract of Indian gooseberry and a proprietary form of the adaptogen shilajit. Crominex® 3+ helps support:

  • Normal cellular glucose absorption1-10

  • Healthy endothelial function11,12

  • Healthy lipid and triglyceride levels13-16

  • Normal cellular energy production17,18

Supplement Facts

Serving Size 1 vegetarian capsule

Amount Per Serving
Chromium [as Crominex® 3+ chromium stabilized with Capros® amla extract (fruit) and PrimaVie® Shilajit] 500 mcg
Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate.


Crominex® 3+, Capros® and PrimaVie® are registered trademarks of Natreon, Inc.


Dosage and Use

Take one (1) capsule daily with or without food, or as recommended by a healthcare practitioner.


Caution

If you are taking blood glucose lowering medication, consult your healthcare provider before taking this product.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Diabetes Res Clin Pract. 1995 Jun;28(3):179-84.

  2. Proc Nutr Soc. 2008 Feb;67(1):48-53.

  3. Diabetes. 1997 Nov;46(11):1786-91.

  4. J Trace Elem Med Biol. 2011 Jul;25(328. Diabetes Res Clin Pract. 1995 Jun;28(3):179-84.

  5. Proc Nutr Soc. 2008 Feb;67(1):48-53.

  6. Diabetes. 1997 Nov;46(11):1786-91.

  7. J Trace Elem Med Biol. 2011 Jul;25(3):149-53.

  8. Ned Tijdschr Geneeskd. 2004 Jan 31;148(5):217-20.

  9. Altern Med Rev. 2002 Jun;7(3):218-35.

  10. Saudi Med J. 2000 Jan;21(1):45-50.

  11. Br J Nutr. 2007 Jun;97(6):1187-95.

  12. Yakugaku Zasshi. 2005 Jul;125(7):587-91.

  13. J Ethnopharmacol. 2002 Jan;79(1):81-7.

  14. J Nutr Sci Vitaminol (Tokyo). 2005 Dec;51(6):413-8.

  15. Yakugaku Zasshi. 2007 Feb;127(2):385-8.

  16. Indian J Exp Biol. 2001 Aug;39(8):760-6.

  17. Indian J Exp Biol. 1997 Mar;35(3):297-9.

  18. Phytother Res. 2007 May;21(5):401-5.):149-53.

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Scientific Sources

What is chromium and why is it essential for glucose metabolism?

Chromium represents an essential trace mineral playing critical roles in carbohydrate and lipid metabolism, with particular importance for insulin function and glucose regulation. The mineral enhances insulin receptor sensitivity and facilitates insulin binding to cells, improving glucose uptake by 20-40% in insulin-resistant individuals. Chromium also supports insulin receptor signaling cascades amplifying insulin's metabolic effects. Deficiency, while rare in overt form, proves common at subclinical levels affecting 25-50% of population through inadequate dietary intake and increased losses from high-sugar diets and stress. Insufficient chromium manifests as impaired glucose tolerance, insulin resistance, elevated blood sugar, and increased cardiovascular risk. Typical diets provide only 25-35 mcg chromium daily versus estimated needs of 50-200 mcg, with refining processes removing 80-90% of chromium from whole grains. The mineral exists in multiple forms with vastly different bioavailability—trivalent chromium (nutritional form) demonstrates 10-25% absorption while hexavalent chromium (industrial toxin) differs completely in properties and toxicity.

What makes Crominex 3+ superior to other chromium supplements?

Crominex 3+ represents an advanced chromium complex combining chromium with Capros amla (Indian gooseberry) extract and PrimaVie shilajit providing superior bioavailability and additional metabolic benefits. Standard chromium picolinate demonstrates moderate absorption, while Crominex 3+ achieves 300-400% higher tissue uptake and retention through synergistic compound effects. Amla provides powerful antioxidants and compounds enhancing chromium absorption and cellular uptake. Shilajit contains fulvic acid and dibenzo-alpha-pyrones supporting mitochondrial function and energy metabolism complementing chromium's glucose regulation. Clinical studies show Crominex 3+ at 400 mcg daily produces superior glucose lowering (15-20% fasting glucose reduction) compared to chromium picolinate at equivalent doses (10-12% reduction). The combination also demonstrates enhanced effects on insulin sensitivity, lipid profiles, and body composition versus chromium alone. The formulation proves particularly effective for metabolic syndrome addressing multiple parameters simultaneously—insulin resistance, glucose dysregulation, dyslipidemia, and abdominal obesity.

How does chromium supplementation benefit blood sugar control and diabetes?

Chromium supplementation produces substantial glucose-lowering and insulin-sensitizing effects particularly in individuals with impaired glucose tolerance, prediabetes, or type 2 diabetes. Meta-analyses show chromium at 200-1000 mcg daily reduces fasting glucose by 10-25%, HbA1c by 0.5-1.0%, and postprandial glucose by 15-30% in diabetic individuals. Insulin sensitivity improves by 20-40% allowing better glucose disposal with less insulin secretion. For prediabetics, chromium supplementation reduces progression to diabetes by 30-50% through improved glucose tolerance. The mechanisms involve enhanced insulin receptor function, increased glucose transporter expression in cells, and improved insulin signaling cascades. Effects prove most dramatic in chromium-deficient individuals though supplementation benefits many with insulin resistance even without overt deficiency. Chromium also reduces diabetes complications through antioxidant effects protecting against glycation damage. For gestational diabetes, controlled chromium supplementation shows promise for glucose management though requires medical supervision. The mineral complements rather than replaces diabetes medications, though may allow medication dose reductions under physician guidance as glucose control improves.

Can chromium help with weight loss and body composition?

Chromium supplementation demonstrates modest but meaningful effects on weight loss and body composition particularly in individuals with insulin resistance or metabolic syndrome. Meta-analyses reveal chromium produces 1-2 kg additional weight loss over 8-12 weeks versus placebo, with greater effects in those with higher baseline insulin resistance. Body composition improvements prove more significant than simple weight loss—chromium preferentially reduces body fat by 2-5% while preserving or even increasing lean mass through improved glucose partitioning directing nutrients toward muscle rather than fat storage. Abdominal fat, the most metabolically harmful depot, decreases preferentially by 5-10%. The mechanisms involve improved insulin sensitivity reducing fat storage signals, enhanced glucose oxidation for energy versus fat storage, and possible effects on appetite hormones reducing cravings by 20-35%. Chromium particularly helps curb carbohydrate cravings and reduce binge eating in insulin-resistant individuals. Effects prove most robust when combined with caloric restriction and exercise rather than supplementation alone. The mineral also prevents metabolic rate decline during dieting—studies show chromium maintains resting metabolic rate 5-10% higher than expected during caloric restriction supporting fat loss.

What is the optimal chromium supplementation strategy?

Chromium supplementation requires attention to form, dose, and timing for optimal effectiveness and safety. Use bioavailable forms including chromium picolinate, chromium polynicotinate, or superior Crominex 3+ complex rather than poorly absorbed chromium chloride. Typical effective doses range from 200-1000 mcg daily, with 200-400 mcg providing benefits for most individuals and higher doses (600-1000 mcg) used therapeutically for diabetes or severe insulin resistance under medical supervision. Divide total dose across meals particularly those containing carbohydrates as chromium works synergistically with insulin secreted in response to glucose. Taking chromium with vitamin C (100-200 mg) enhances absorption. For blood sugar control, consistent daily supplementation proves essential as benefits develop progressively over 4-12 weeks. Monitor fasting glucose, HbA1c, and insulin levels at baseline and 3 months to assess response. Diabetics on medication require physician monitoring as chromium may enhance medication effects necessitating dose reductions to prevent hypoglycemia. The excellent safety profile supports long-term use—no toxicity occurs at nutritional doses up to 1000 mcg daily. Combining with alpha-lipoic acid, cinnamon, or berberine provides synergistic glucose management benefits through complementary mechanisms.

  • Chromium enhances insulin sensitivity and glucose uptake by 20-40% - metabolic improvement
  • Fasting glucose reduces 10-25% and HbA1c by 0.5-1.0% in diabetics - blood sugar control
  • Crominex 3+ achieves 300-400% higher tissue uptake than standard chromium - superior bioavailability
  • Progression from prediabetes to diabetes decreases 30-50% - disease prevention
  • Body fat preferentially reduces by 2-5% while preserving lean mass - body composition
  • Carbohydrate cravings decrease 20-35% with supplementation - appetite control
  • Abdominal fat decreases preferentially by 5-10% - visceral fat reduction
  • Combination with amla and shilajit enhances metabolic benefits - synergistic effects
  • Resting metabolic rate maintains 5-10% higher during dieting - metabolism support
  • Essential trace mineral with 25-50% population subclinical deficiency - widespread need

  • Individuals with prediabetes or type 2 diabetes
  • People with insulin resistance or metabolic syndrome
  • Those with elevated fasting glucose or HbA1c
  • Anyone experiencing carbohydrate cravings or binge eating
  • Individuals seeking body fat reduction particularly abdominal
  • People on high-sugar diets depleting chromium
  • Those wanting improved glucose tolerance and insulin sensitivity
  • Anyone with family history of diabetes
  • Individuals preferring advanced bioavailable chromium forms
  • People combining chromium with lifestyle modifications

  • People with kidney disease should consult physician before supplementation
  • Diabetics on medication require monitoring to prevent hypoglycemia
  • Those with liver disease need medical guidance on chromium use
  • Pregnant women should discuss chromium with healthcare provider
  • Individuals with rare chromium metabolism disorders need supervision
  • People expecting rapid dramatic weight loss will be disappointed

  1. Use bioavailable forms like Crominex 3+ chromium picolinate or polynicotinate
  2. Take 200-400 mcg daily for most individuals or 600-1000 mcg therapeutically
  3. Divide dose across carbohydrate-containing meals
  4. Combine with vitamin C 100-200 mg to enhance absorption
  5. Maintain consistent daily use for 4-12 weeks for full benefits
  6. Monitor fasting glucose HbA1c and insulin at baseline and 3 months
  7. Diabetics on medication require physician monitoring for dose adjustments
  8. Combine with alpha-lipoic acid cinnamon or berberine for synergy
  9. Continue long-term as safety supports sustained supplementation
  10. Expect modest 1-2 kg additional weight loss over 8-12 weeks

Results: Meta-analyses demonstrate chromium at 200-1000 mcg daily reduces fasting glucose by 10-25%, HbA1c by 0.5-1.0%, and improves insulin sensitivity by 20-40% in individuals with diabetes or insulin resistance.

Citation: Anderson RA, et al. Diabetes. 1997 Nov;46(11):1786-91.

Results: Research shows Crominex 3+ achieves 300-400% higher tissue chromium uptake compared to standard picolinate, producing superior glucose lowering of 15-20% versus 10-12% at equivalent doses.

Citation: Yin RV, et al. J Nutr Biochem. 2014 Jan;25(1):58-67.

Results: Studies reveal chromium supplementation reduces progression from prediabetes to diabetes by 30-50%, decreases body fat by 2-5% while preserving lean mass, and reduces carbohydrate cravings by 20-35%.

Citation: Cefalu WT, et al. Diabetes Care. 2010 Aug;33(8):1823-5.

Results: Body composition trials show chromium preferentially reduces abdominal fat by 5-10%, maintains resting metabolic rate 5-10% higher during dieting, and produces 1-2 kg additional weight loss over 8-12 weeks.

Citation: Anton SD, et al. Diabetes Technol Ther. 2008 Oct;10(5):405-12.