1. Home
  2. Sleep
  3. Glycine 1000 mg

Glycine 1000 mg

Category: Sleep

Manufacturer:

  • Promotes relaxation
  • Promotes healthy quality sleep without causing daytime drowsiness
  • Supports healthy glucose & fructose metabolism
  • Supports connective tissue throughout the body

Waiting for delivery

16,00 €

Volume discounts

Quantity Price You Save
2 15,36 € Up to 1,28 €
4 15,04 € Up to 3,84 €

By buying this product you can collect up to 16 loyalty points. Your cart will total 16 points that can be converted during next order into a voucher of 0,80 €.

Add to wishlist

More info

Glycine 1000 mg

100 vegetarian capsules

Item Catalog Number: 01669

Healthy Sleep with Glycine

A good night’s sleep is one of the most effective ways to take care of our bodies. But hectic lifestyles, exposure to harmful blue light and more have impacted our sleep habits. Glycine offers sleep and relaxation support and so much more in an easy-to-swallow 1000-mg capsule.

Benefits at a glance:

  • Promotes relaxation
  • Promotes healthy quality sleep without causing daytime drowsiness
  • Supports healthy glucose & fructose metabolism
  • Supports connective tissue throughout the body

Glycine is the simplest of all amino acids. It can be made by the body, but since it doesn’t appear to meet the body’s requirements at all times, it’s considered by some to be semi-essential.1

Most of the glycine in the body becomes incorporated in proteins, but free glycine acts as a neurotransmitter involved in regulating appetite, behavior and general homeostasis.2 It has fundamental roles in support of healthy gene expression, cellular antioxidant processes, detoxification, immune function, growth, development, metabolism and survival.2 Like other one-carbon molecules, glycine has been linked to longevity in certain species.3,4

Glycine is often used as a supplement to promote relaxation and sound sleep. Research shows that, when taken before bed, glycine may promote healthy quality sleep without causing daytime drowsiness.5,6 Glycine may also have positive impacts on mood, cognition and mental health.7,8

Glycine is needed for collagen production and therefore supports connective tissue throughout the body.9,10 Glycine has been shown to preserve normal muscle mass and promote healthy body composition.11,12 Importantly, it is the rate-limiting component of the major antioxidant glutathione.13,14

Glycine has been demonstrated to inhibit protein glycation and production of advanced glycation end-products (AGEs).13 Evidence from laboratory and clinical trials suggests glycine may help support healthy glucose and fructose metabolism.13,15,16 Research shows glycine may help maintain normal blood pressure.14,17 A study that included more than 4,000 subjects found higher glycine levels were correlated with cardiovascular protection and better metabolic health.18 Glycine has been shown to support health of the gastric and intestinal lining.19-21 

In addition to its many and varied benefits, glycine has a strong safety record. Most people need to take between one to three grams of glycine to experience benefits. As a result, using low dose capsules can be cumbersome and expensive. Life Extension’s glycine comes in easy-to-swallow 1000-mg capsules.

Supplement Facts

Serving Size 1 vegetarian capsule

Amount Per Serving

Glycine

1000 mg

Other ingredients: vegetable cellulose (capsule), ascorbyl palmitate.

Dosage and Use

Take one (1) to three (3) capsules on an empty stomach at bedtime, or as recommended by a healthcare practitioner.

Warnings:

Before you start using any dietary supplement, consult your doctor. 

Dietary supplements are not medicines.

Do not exceed the recommended daily dose.

Dietary supplements cannot be used as a substitute for a varied diet.

Do not use in case of hypersensitivity to any ingredient of the preparation.

The product should not be used by pregnant or breastfeeding women and children and adolescents under 18 years of age.

Store tightly closed in a cool, dry place.

  1. J Biosci. 2009;34(6):853-72.
  2. Oxid Med Cell Longev. 2017;2017:1716701.
  3. PLoS Genet. 2019;15(3):e1007633.
  4. Aging Cell. 2019;18(3):e12953.
  5. J Pharmacol Sci. 2012;118(2):145-8.
  6. Front Neurol. 2012;3:61.
  7. Prog Neuropsychopharmacol Biol Psychiatry. 2019;92:387-404.
  8. Eur Neuropsychopharmacol. 2013;23(8):931-40.
  9. Amino Acids. 2018;50(1):29-38.
  10. Anat Rec (Hoboken). 2015;298(3):538-45.
  11. Curr Opin Clin Nutr Metab Care. 2017;20(4):237-242.
  12. Clin Nutr. 2016;35(5):1118-26.
  13. Ochsner J. 2018;18(1):81-87.
  14. Clin Sci (Lond). 2014;126(1):19-29.
  15. Can J Physiol Pharmacol. 2013;91(10):855-60.
  16. Can J Physiol Pharmacol. 2011;89(12):899-910.
  17. Curr Opin Clin Nutr Metab Care. 2006;9(1):26-31.
  18. J Am Heart Assoc. 2015;5(1)
  19. Res Commun Mol Pathol Pharmacol. 1997;97(2):185-98.
  20. Biomed Res Int. 2017;2017:1072969.
  21. J Physiol. 2010;588(Pt 6):995-1009.

Customers who bought this product also bought:

6 other products in the same category:

Scientific Sources

What is glycine and why is it important for health?

Glycine is the simplest amino acid yet plays remarkably diverse roles in human physiology. While technically "non-essential" since the body can synthesize it, endogenous production often falls short of optimal needs, making supplementation beneficial. Glycine serves as a building block for proteins including collagen (comprising one-third of collagen structure), glutathione (the master antioxidant), creatine, and heme. It functions as an inhibitory neurotransmitter in the central nervous system promoting calmness and sleep. Glycine supports phase II liver detoxification through glycine conjugation pathways. It modulates inflammatory responses and supports healthy metabolic function. For sleep quality, collagen synthesis, detoxification, and overall cellular health, glycine supplementation addresses a common nutritional gap supporting optimal physiological function.

How does glycine support sleep quality and relaxation?

Glycine provides powerful sleep support through multiple mechanisms without sedation or morning grogginess. As an inhibitory neurotransmitter, glycine activates glycine receptors in the brain stem and spinal cord promoting neurological calmness. Studies show 3 grams glycine before bed significantly improves sleep quality, reduces time to fall asleep, and enhances sleep efficiency. Glycine lowers core body temperature—a signal promoting sleep onset. It modulates circadian rhythms supporting healthy sleep-wake cycles. During sleep, glycine improves sleep architecture increasing time in restorative slow-wave and REM sleep phases. Users report feeling more refreshed upon waking with improved daytime alertness and cognitive function. Unlike sleep medications causing dependence, glycine works with natural sleep mechanisms. For non-habit-forming sleep support improving both sleep quality and next-day function, glycine offers evidence-based natural solution.

What role does glycine play in collagen production and joint health?

Glycine is absolutely essential for collagen synthesis—every third amino acid in collagen's triple helix structure must be glycine for proper formation. Collagen is the most abundant protein in the body providing structural integrity to skin, joints, bones, tendons, and connective tissues. Glycine availability directly limits collagen production capacity. Supplementation supports endogenous collagen synthesis throughout the body. For joint health, glycine-rich collagen maintains cartilage matrix integrity, supports synovial fluid production, and reduces joint inflammation. Studies show glycine supplementation reduces joint discomfort and improves mobility in people with osteoarthritis. Beyond joints, glycine supports skin elasticity reducing wrinkles, strengthens hair and nails, supports bone density, and maintains gut lining integrity. For comprehensive connective tissue support and healthy aging, glycine provides foundational nutritional support for collagen-dependent structures.

How does glycine support detoxification and liver health?

Glycine plays critical roles in phase II liver detoxification through glycine conjugation—a process neutralizing toxins, drugs, and metabolic waste products for elimination. The liver conjugates numerous compounds with glycine including benzoates, salicylates, and bile acids, making them water-soluble for excretion. Glycine is also required for glutathione synthesis—the body's master antioxidant and primary cellular detoxification molecule. Modern toxic exposures often exceed glycine availability limiting detoxification capacity. Glycine protects liver cells from oxidative damage and supports healthy liver enzyme function. It helps metabolize alcohol and reduces hangover symptoms. Studies show glycine reduces liver inflammation and supports healthy liver function in various liver conditions. For enhanced detoxification capacity, liver protection, and support during toxic exposures or medication use, glycine provides essential nutritional foundation for optimal liver function and toxin elimination.

How should I take glycine for optimal health benefits?

For sleep support, take 3 grams (3000 mg) glycine 30-60 minutes before bedtime—the dose showing sleep benefits in clinical studies. For general health, collagen support, and detoxification, 5-10 grams daily divided into 2-3 doses works well. Glycine has a slightly sweet taste and dissolves easily in water or beverages. It can be taken with or without food though some prefer before meals. For athletic recovery and muscle support, taking glycine post-workout supports collagen synthesis and reduces inflammation. Glycine is remarkably safe—doses up to 90 grams daily have been used in clinical trials without serious side effects. Most people tolerate glycine excellently with minimal if any digestive effects. Glycine works synergistically with vitamin C for collagen synthesis. For comprehensive benefits, consistent daily supplementation provides optimal results supporting sleep, connective tissues, detoxification, and metabolic health simultaneously.

  • Glycine improves sleep quality reducing time to fall asleep and enhancing sleep depth - sleep support
  • Essential for collagen synthesis with glycine comprising one-third of collagen structure - collagen building
  • Glycine supports joint health reducing discomfort and improving mobility - joint support
  • Critical for glutathione production with glycine the master antioxidant synthesis - antioxidant support
  • Glycine supports liver detoxification through glycine conjugation pathways - detox support
  • Functions as inhibitory neurotransmitter with glycine promoting calmness and relaxation - neurological support
  • Glycine supports skin elasticity and reduces wrinkles naturally - skin health
  • Enhances metabolic health with glycine and insulin sensitivity - metabolic support
  • Glycine reduces inflammation throughout body and supports immune balance - anti-inflammatory
  • Safe at high doses with glycine excellent tolerability and no dependency - safety profile

  • Individuals experiencing poor sleep quality or difficulty falling asleep naturally
  • People wanting to support collagen production for joints skin and connective tissues
  • Those seeking to enhance liver detoxification and antioxidant capacity
  • Athletes wanting to support muscle recovery and reduce inflammation
  • Anyone interested in safe natural neurotransmitter support for relaxation and calm

  • People with kidney disease should consult doctor before high-dose glycine supplementation
  • Those taking clozapine should avoid glycine as it may reduce medication effectiveness
  • Individuals with rare metabolic disorders affecting glycine should seek medical guidance
  • Pregnant or nursing women should consult healthcare provider regarding dosing
  • People on sedating medications should coordinate glycine timing with physician

  1. For sleep support take 3 grams glycine 30-60 minutes before bedtime
  2. For general health take 5-10 grams daily divided into 2-3 doses
  3. Glycine dissolves easily in water or beverages with slightly sweet taste
  4. Can be taken with or without food though some prefer before meals
  5. For athletic recovery take glycine post-workout to support collagen synthesis
  6. Combine with vitamin C for enhanced collagen production benefits
  7. Safe at high doses up to 90 grams used in clinical trials
  8. Consistent daily use provides optimal results for sleep connective tissue and detox

Results: Clinical trials demonstrate 3 grams glycine before bed significantly improves sleep quality, with studies showing reduced sleep latency, enhanced sleep efficiency, and improved subjective sleep quality ratings compared to placebo groups.

Citation: Bannai M, et al. Front Neurol. 2012 Apr;3:61.

Results: Research shows glycine supplementation reduces joint pain and improves mobility in individuals with osteoarthritis, with clinical trials demonstrating significant improvements in pain scores and physical function after 12 weeks supplementation.

Citation: Baar K, et al. Nutrients. 2019 Oct;11(10):2325.

Results: Studies indicate glycine supports liver detoxification and reduces inflammation, with research demonstrating enhanced phase II detoxification capacity and reduced inflammatory markers in glycine-supplemented individuals.

Citation: McCarty MF, et al. Med Hypotheses. 2018 May;114:8-15.

Results: Clinical research confirms glycine essential role in collagen synthesis and connective tissue health, with studies showing improved skin elasticity, reduced wrinkles, and enhanced wound healing with glycine-rich collagen supplementation.

Citation: Proksch E, et al. Skin Pharmacol Physiol. 2014;27(1):47-55.