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Science-based food supplements
Manufacturer: Life Extension
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Super Vitamin E
Item Catalog Number: 01863EU
268 mg (400 IU), 90 softgels
Vitamin E is essential for overall health. It offers antioxidant protection and promotes a healthy whole-body inflammatory response, which can promote heart, brain and immune health. And with our Super Vitamin E, you get a non-synthetic form that is more bioavailable than synthetic vitamin E.
Benefits at a Glance :
Vitamin E is essential for overall health. Our Super Vitamin E is more bioavailable than synthetic forms of vitamin E. It contains a non-synthetic form of alpha-tocopherol that is distributed throughout the body more efficiently.
The non-synthetic form of alpha-tocopherol in our Super Vitamin E is distributed throughout the body more efficiently than the synthetic version. Specific carrier proteins in the liver selectively bind to the more absorbable form of vitamin E (non-synthetic), transporting it through the blood to your cells. These carrier proteins only recognize a portion of synthetic vitamin E, ignoring the rest.1-4
Japanese researchers compared the synthetic and non-synthetic forms of vitamin E by supplementing young women with either form for one month and measuring vitamin E levels in their blood. It took only 100 mg of the natural form to produce the same blood levels as 300 mg of synthetic vitamin E.5
Serving Size 1 softgel
| Amount per day (1 softgel) | |
| Vitamin E (as d-alpha tocopherol from sunflower oil) | 268 mg |
|
Ingredients: Mixed tocopherols (vitamin E), capsule (gelatin, humectant: glycerol, water) |
|
Non - GMO
If you are taking anticoagulant or antiplatelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.
Super Vitamin E provides natural mixed tocopherols rather than just alpha-tocopherol found in standard vitamin E supplements. Natural vitamin E consists of four tocopherols (alpha, beta, gamma, and delta) and four tocotrienols, each with distinct health benefits. While alpha-tocopherol is important, gamma-tocopherol and other forms offer unique antioxidant properties and health benefits that alpha alone cannot provide. Natural mixed tocopherols provide broader antioxidant protection throughout the body. The 268 mg (400 IU) dose provides substantial antioxidant support while the natural form ensures better bioavailability and utilization compared to synthetic dl-alpha-tocopherol commonly found in cheaper supplements.
Vitamin E is the body's primary fat-soluble antioxidant, protecting cell membranes and lipid-rich tissues from oxidative damage. It works by donating electrons to neutralize free radicals—unstable molecules that damage cells through oxidation. Once vitamin E neutralizes a free radical, it becomes oxidized itself but can be regenerated by vitamin C and other antioxidants, creating a protective antioxidant network. Vitamin E is particularly effective at preventing lipid peroxidation—the oxidation of fats in cell membranes that can trigger cell damage and inflammation. This protection is crucial for maintaining healthy cardiovascular, immune, skin, and neurological function throughout life.
Vitamin E offers comprehensive health benefits through its antioxidant and anti-inflammatory properties. It supports cardiovascular health by protecting LDL cholesterol from oxidation, supporting healthy blood vessel function, and promoting proper blood flow. Vitamin E supports immune function, enhancing both innate and adaptive immunity, particularly important as people age. It promotes skin health by protecting against UV damage and supporting skin moisture and elasticity. Vitamin E supports cognitive function and may help maintain brain health with aging. It supports eye health by protecting retinal tissues from oxidative damage. The vitamin also supports muscle health, reduces exercise-induced oxidative stress, and promotes healthy inflammatory responses throughout the body.
The 400 IU (268 mg) dose is well within safe limits and has been extensively studied. The recommended dietary allowance for vitamin E is 15 mg (22 IU) daily, but many experts believe higher doses provide optimal antioxidant protection, particularly for older adults or those with increased oxidative stress. The tolerable upper intake level is 1,000 mg (1,500 IU) daily for adults. Clinical studies have used doses ranging from 200-800 IU daily safely for extended periods. However, people taking blood-thinning medications should consult physicians before using high-dose vitamin E as it can enhance anticoagulant effects. For most healthy adults, 400 IU daily is safe and provides substantial antioxidant benefits.
For best absorption, take vitamin E with a meal containing dietary fat, as it is fat-soluble and requires fat for proper absorption. Taking with your largest meal of the day ensures adequate fat intake. Consistency matters—take vitamin E at the same time daily to maintain steady antioxidant protection. The effects are cumulative, with maximum benefits appearing after several months as vitamin E accumulates in tissues. Avoid taking vitamin E simultaneously with iron supplements as they can interfere with each other; space them by several hours. Vitamin E works synergistically with vitamin C and other antioxidants, so comprehensive antioxidant supplementation provides optimal protection. Store in a cool place to prevent oxidation of the oil.
Results: Clinical studies demonstrate vitamin E supplementation significantly reduces markers of oxidative stress and lipid peroxidation, with doses of 400-800 IU daily showing substantial improvements in antioxidant status and cellular protection in multiple trials.
Citation: Meydani M, et al. Am J Clin Nutr. 1998 Aug;68(2):311-8.
Results: Research shows vitamin E supports cardiovascular health by inhibiting LDL oxidation, with studies demonstrating 30-40% reductions in oxidized LDL levels in supplemented individuals, potentially reducing cardiovascular risk associated with oxidized cholesterol particles.
Citation: Jialal I, et al. Circulation. 1996 Nov;94(10):2434-40.
Results: Studies indicate vitamin E enhances immune function particularly in older adults, with supplementation improving T-cell function, antibody responses, and resistance to infections in elderly populations experiencing age-related immune decline.
Citation: Meydani SN, et al. JAMA. 2004 Aug;292(7):828-36.
Results: Clinical trials confirm mixed tocopherol supplements provide superior antioxidant protection compared to alpha-tocopherol alone, with gamma-tocopherol offering unique benefits for trapping reactive nitrogen species and supporting healthy inflammatory responses.
Citation: Jiang Q, et al. Am J Clin Nutr. 2001 Oct;74(4):714-22.