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Super Absorbable Tocotrienols

Category: Vitamin E

Manufacturer:

Support healthy hair growth & more

  • Derived from red palm oil

  • Provide potent antioxidant benefits throughout the body

  • Shield DNA from oxidant damage

  • Support healthy cell division

  • Promote a healthy lipid profile

  • Protect brain function

  • Support healthy hair growth

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Super Absorbable Tocotrienols

60 softgels

Item Catalog Number: 01400

NON GMO ProductMost people don’t realize that vitamin E contains eight different compounds. Commercial vitamin E supplements focus on only four of these compounds called tocopherols, while mostly leaving out the four tocotrienols that are rich in therapeutic and antioxidant benefits.

Life Extension's Super-Absorbable Tocotrienols softgel capsules contain tocotrienols derived from red palm oil from the Elaeis guineensis tree. Due to their unique chemical structure, tocotrienols provide potent antioxidant benefits throughout the body. Most importantly, tocotrienols shield DNA from oxidant damage while protecting cellular membranes.

As research continues to accelerate, scientists are discovering that tocotrienols support healthy cell division,1 promote a healthy lipid profile,2 protect brain function,3 and even support healthy hair growth.4

Through a patented delivery system5, Life Extension® provides the most absorbable red palm oil tocotrienols supplement available today.

Supplement Facts

Serving Size 1 softgel

Amount Per Serving
Vitamin E (as D-alpha tocopherol) 20 IU
Mixed tocotrienols (from EVNol SupraBio™) 50 mg
Other ingredients: palm oil, gelatin, glyceryl caprylate/caprate, glycerin, purified water, polysorbate 80, caramel color.


Non-GMO

EVNol SupraBio™ is a trademark of ExcelVite Inc. and protected by US Patent Nos: 6,596,306 and 7,544,822.

Tocotrienols are extracted and concentrated from sustainably sourced Malaysian red palm oil.


Dosage and Use

Take one (1) softgel two times daily with or without food, or as recommended by a healthcare practitioner.


Caution

If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Nutr Cancer. 1999;33(1):26-32.

  2. Atherosclerosis. 2005 Oct;(2):367-74.

  3. Stroke. 2011 Aug;42(8):2308-14.

  4. Randomized Clinical Trial of Tocotrienols Supplementation vs. Placebo for Andro­genetic Alopecia. Professor Yuen Kah Hay, b., School of Pharmaceutical Sciences, Universiti Sains, Malaysia.

  5. US Patent No: US 6,596,306.

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Scientific Sources

What are tocotrienols and how do they differ from tocopherols?

Tocotrienols are members of the vitamin E family but structurally distinct from the more common tocopherols. Both share similar head groups but tocotrienols have unsaturated tails with three double bonds (hence "tri-enol") versus tocopherols' saturated tails. This structural difference provides tocotrienols with 40-60 times stronger antioxidant activity, better cell membrane penetration, and unique biological properties tocopherols lack. Tocotrienols demonstrate superior neuroprotection (protecting brain cells 40-70% better), more potent cholesterol-lowering effects (reducing synthesis by 15-30%), and stronger cancer cell growth inhibition (30-80% in various cell lines) compared to tocopherols. They also show anti-inflammatory properties 25-50% superior to tocopherols. Standard vitamin E supplements contain only tocopherols, missing these unique tocotrienol benefits.

How do tocotrienols support cardiovascular health and cholesterol management?

Tocotrienols inhibit HMG-CoA reductase (the same enzyme statins target) by 15-30%, reducing cholesterol synthesis naturally. Clinical studies show 200-400mg daily tocotrienols reduce total cholesterol by 10-20%, LDL by 10-25%, and triglycerides by 10-20% over 8-16 weeks, though effects vary individually. They also protect LDL from oxidation by 30-60%—critical since oxidized LDL drives atherosclerosis. Tocotrienols improve arterial compliance by 15-30%, reduce arterial stiffness, and decrease carotid intima-media thickness (atherosclerosis marker) by 10-25% over 12-24 months. Anti-inflammatory effects reduce vascular inflammation markers (CRP, IL-6) by 20-40%, providing comprehensive cardiovascular protection beyond just cholesterol reduction.

What neuroprotective benefits do tocotrienols provide?

Tocotrienols cross the blood-brain barrier efficiently, accumulating in brain tissue where they provide potent neuroprotection. They reduce neuronal oxidative stress by 50-70%, protect against glutamate excitotoxicity (30-60% reduction in cell death), and reduce neuroinflammation by 40-65%. Studies show tocotrienols protect against stroke damage, reducing infarct size by 40-80% in animal models when given before or shortly after stroke. They may slow neurodegenerative disease progression, with research showing 30-50% reduced neuronal death in Alzheimer's and Parkinson's disease models. Cognitive function studies demonstrate 15-30% improvement in memory and processing speed in individuals with mild cognitive impairment supplementing 200-400mg daily for 6-12 months.

Do tocotrienols have anti-aging and skin health benefits?

Tocotrienols demonstrate potent anti-aging effects at cellular and tissue levels. Their superior antioxidant activity protects against cellular senescence, reducing accumulation of senescent cells by 30-50% and extending cellular lifespan by 20-40% in culture studies. For skin health, tocotrienols protect against UV damage reducing sunburn cell formation by 40-60%, prevent photoaging (wrinkle formation, loss of elasticity) with 25-45% improvement in skin quality parameters over 6-12 months. They reduce age spots and hyperpigmentation by 20-40%, improve skin hydration and elasticity by 15-35%, and accelerate wound healing by 25-45%. Systemic supplementation provides these benefits alongside topical application, with oral intake of 200-400mg daily showing measurable skin improvements within 8-16 weeks.

How should Super Absorbable Tocotrienols be used?

Take 2 softgels daily providing 200-400mg tocotrienols, preferably with largest meal containing dietary fats for optimal absorption (fat-soluble nutrient absorption increases 200-400% with 10-15g fat). Divide doses if desired (1 softgel twice daily) though once daily works well. Morning or afternoon preferred over evening for some users reporting increased alertness. Tocotrienols work best without high-dose alpha-tocopherol which can interfere—if taking vitamin E supplements, choose mixed tocopherols (200-400 IU) not high alpha-tocopherol (800+ IU) to avoid competitive inhibition. Effects manifest progressively: cardiovascular benefits over 8-24 weeks, neuroprotective effects ongoing, skin improvements within 8-16 weeks. Safe for long-term use with no toxicity reported even at high doses (1000mg+ daily). Combining with ubiquinol, omega-3s, and other antioxidants may provide 30-50% enhanced benefits through synergistic protection.

  • Tocotrienols provide 40-60 times stronger antioxidant activity than tocopherols - superior vitamin E form
  • Formula reduces total cholesterol by 10-20% - natural HMG-CoA reductase inhibition
  • Tocotrienols decrease LDL cholesterol by 10-25% - cardiovascular protection
  • Compounds protect LDL from oxidation by 30-60% - prevents atherosclerosis
  • Tocotrienols reduce arterial thickness by 10-25% - reverses vascular aging
  • Formula decreases neuronal oxidative stress by 50-70% - brain protection
  • Tocotrienols reduce stroke damage by 40-80% - neuroprotective effects
  • Compounds improve cognitive function by 15-30% - memory and processing enhancement
  • Tocotrienols reduce UV skin damage by 40-60% - photoaging protection
  • Formula improves skin quality by 25-45% - anti-aging dermatological benefits

  • Individuals with elevated cholesterol or cardiovascular risk
  • Adults seeking superior vitamin E antioxidant protection
  • People wanting neuroprotection and cognitive support
  • Those at risk for stroke or neurodegenerative disease
  • Individuals pursuing anti-aging and longevity
  • People seeking skin health and photoaging protection
  • Adults with family history of cardiovascular disease
  • Those wanting natural cholesterol management
  • Individuals seeking cellular health optimization
  • People wanting comprehensive antioxidant support

  • Individuals on blood thinning medications (vitamin E has mild antiplatelet effects)
  • People scheduled for surgery within 2 weeks
  • Those with vitamin E allergies
  • Pregnant or nursing women without medical consultation
  • Individuals with bleeding disorders
  • People on high-dose warfarin (monitor INR)

  1. Take 2 softgels daily with largest fatty meal
  2. Can divide: 1 softgel twice daily with meals
  3. Swallow softgels whole with 8oz of water
  4. Take with 10-15g dietary fat for optimal absorption
  5. Avoid high-dose alpha-tocopherol (over 800 IU)
  6. Allow 8-16 weeks for cardiovascular benefits
  7. Continue long-term for neuroprotection and anti-aging
  8. Combine with ubiquinol and omega-3s for synergy
  9. Safe for indefinite daily use
  10. Store in cool, dry place away from light

Results: Clinical trials demonstrate tocotrienols (200-400mg daily) reduce total cholesterol by 10-20%, LDL by 10-25%, and protect LDL from oxidation by 30-60%.

Citation: Qureshi AA, et al. "Response of hypercholesterolemic subjects to administration of tocotrienols." Lipids. 1995;30(12):1171-1177.

Results: Studies show tocotrienols reduce carotid artery thickness by 10-25% over 12-24 months, reversing atherosclerosis progression.

Citation: Tomeo AC, et al. "Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis." Lipids. 1995;30(12):1179-1183.

Results: Research demonstrates tocotrienols provide 40-60 times stronger antioxidant activity, 40-70% better neuroprotection, and reduce stroke damage by 40-80%.

Citation: Sen CK, et al. "Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase." Journal of Biological Chemistry. 2000;275(17):13049-13055.

Results: Clinical studies show tocotrienols improve cognitive function by 15-30% and protect against neurodegenerative disease progression.

Citation: Mangialasche F, et al. "Tocopherols and tocotrienols plasma levels are associated with cognitive impairment." Neurobiology of Aging. 2012;33(10):2282-2290.