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Food Sensitivity Relief with Diamine Oxidase (DAO)

Category: Histamine and DAO

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  • Helps alleviate occasional gas and stomach upset, as well as other gastrointestinal discomforts
  • Supports histamine metabolism for digestive comfort
  • Provides support for when you snack on histamine-rich foods and drinks like cured meats, cheeses, wine

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Food Sensitivity Relief with Diamine Oxidase (DAO)

60 delayed release vegetarian capsules

Item Catalog Number: 02533

Cheers to digestive comfort! If you experience occasional gas and stomach upset, as well as other gastrointestinal discomforts when enjoying wine, cured meats, cheese, fermented foods or citrus, you may have a sensitivity to dietary histamine. (Note: this is not the same as a food allergy.) Our formula helps you make friends with your food again by supporting the healthy breakdown of intestinal histamine to encourage gastrointestinal comfort.

What is Food Sensitivity Relief* with Diamine Oxidase (DAO)?

Digestive comfort may not always be on the menu when we pair a glass of wine (or beer) with snacks like cured meats, cheeses, citrus and fermented foods. Food Sensitivity Relief with Diamine Oxidase is formulated to help relieve occasional non-allergy digestive discomfort associated with dietary histamine sensitivity.

Benefits at a glance:

  • Helps alleviate occasional gas and stomach upset, as well as other gastrointestinal discomforts
  • Supports histamine metabolism for digestive comfort
  • Provides support for when you snack on histamine-rich foods and drinks like cured meats, cheeses, wine

How to Stay Comfortable After You Eat

Cured meats, cheeses, wine, and other histamine-rich foods make for a delicious charcuterie board, but not everyone can digest these treats comfortably. Our plant-based DAO formula helps relieve occasional non-allergy digestive discomfort associated with intestinal dietary histamine sensitivity. One more thing: many DAO formulas utilize enzymes derived from animals—usually pork. But our formula uses diamine oxidase from pea sprouts. It’s got the same capacity to break down histamine as animal-based DAO…no pork bellies required.

What is a food sensitivity?

Short answer: a food sensitivity is when the body responds to compounds in the food you eat. A food sensitivity (sometimes referred to as a food intolerance) can cause occasional gastrointestinal discomfort, and is often difficult to identify. A food sensitivity is not an allergic reaction.

That said, non-allergy food sensitivities are more common than you think: currently, almost 20% of the Westernized world’s population experience some type of food intolerance.1 Histamine is a compound found in many foods and drinks that has been associated with food sensitivity.

Histamine is a compound found in many foods and drinks that has been associated with food sensitivity such as occasional gas, stomach upset, as well as other gastrointestinal discomforts.

Diamine oxidase in clinical studies

Diamine oxidase (DAO) is the main enzyme that supports the healthy breakdown of intestinal histamine and encourages gastrointestinal comfort.

In a randomized clinical trial, participants who took dietary DAO supplementation 20 minutes before a main meal for eight weeks reported relief from occasional gastrointestinal discomfort.2

Research also points to the effectiveness of DAO supplements in inhibiting the incidence and intensity of discomfort due to occasional food sensitivity associated with intestinal dietary histamine sensitivity.3,4

Plant-derived DAO

Many sources of supplementary DAO are derived from pig kidneys. But our formula provides pea sprouts derived DAO with equivalent capacity to break down histamine as used in clinical studies.

Make friends with your favorite foods again with Food Sensitivity Relief with Diamine Oxidase (DAO)!

More informations and frequently asked questions:

  • What is histamine? Histamine is a compound that plays a role in the body’s immune response. It is released in the body and can be produced by gut bacteria. Histamine can also be found in or increased by many foods and drinks. Excessive levels of histamine in the gut can cause occasional gastrointestinal-related discomfort including gas and bloating. The body has several enzymes that help break down this compound.
  • What types of foods are considered histamine-rich? Histamine-rich foods and drinks are very common. Some of these include cured and deli meats, different types of cheese, alcoholic beverages like wine and beer, oily fish and even certain fruits and vegetables like citrus, tomatoes and strawberries.
  • Is histamine sensitivity considered an allergy? No, histamine sensitivities are considered a sensitivity to histamine ingested from foods. Food sensitivities are the body’s response to compounds in the food you eat, sometimes referred to as food intolerances. Sensitivities are not considered to be the same as an allergic reaction. They may manifest in the form of occasional gastrointestinal discomforts.
  • Does this product break down whole-body histamine? No, this product is only intended to help support the breakdown of intestinal histamine associated with non-allergy histamine-food sensitivity.
  • What is diamine oxidase (DAO)? Diamine oxidase (DAO) is an enzyme produced by the body that breaks down histamine and is the primary way the body metabolizes histamine in the GI tract. Its activity is measured in HDU, or histamine degrading units. It can be more difficult for people with low levels of DAO to maintain a healthy balance of histamine.
  • What is in Food Sensitivity Relief with Diamine Oxidase (DAO)? Food Sensitivity Relief with Diamine Oxidase contains 20,000 HDU of the enzyme diamine oxidase (DAO), derived from pea sprouts. HDU stands for histamine degrading units and is a measure of enzyme activity.
  • Who is Food Sensitivity Relief with Diamine Oxidase intended for? Food Sensitivity Relief with Diamine Oxidase is intended for those who need help breaking down and metabolizing histamine in the gut and alleviating occasional discomforts associated with dietary histamine sensitivity.
  • When can I expect an effect? In a study of people who took DAO immediately after eating histamine-rich foods, benefits were seen immediately. More long-term effects were observed after taking DAO daily for 4-8 weeks. Everybody is unique, however, so the time it takes to notice benefits can vary from person to person. We suggest following the study duration to determine product efficacy.
  • When is the best time to take Food Sensitivity Relief with Diamine Oxidase? Should it be taken with food or on an empty stomach? We suggest taking one capsule before your heaviest meals, up to three times daily.
  • Will this supplement interact with my medication? There is no indication that the nutrient in this formula would negatively interact with prescription medications. However, we always suggest that you inform your physician of any supplements you are taking.
  • Are there any cautions associated with this product? Food Sensitivity Relief with Diamine Oxidase contains the following caution: This product breaks down histamine but won’t prevent severe allergic or gluten-related (celiac) reactions. Do not knowingly ingest food you are allergic to.
  • Has this product been tested for heavy metals, contaminants and potency? All our raw materials and finished products go through stringent testing to meet our high-quality standards. Testing is performed for heavy metals, microbes, disintegration, potency, and quantity of active ingredients in the finished product. Only when finished products meet Life Extension’s specifications are they released for production. A finished product Certificate of Analysis (COA) can be provided upon request for all our products.
  • Are there any major allergens in this product? Food Sensitivity Relief with Diamine Oxidase does not contain any of the 9 major allergens required on the label under the Food Allergy Safety, Treatment, Education, and Research (FASTER) Act. This means it is free of milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, sesame and soybeans.
  • Where is this product manufactured? Food Sensitivity Relief with Diamine Oxidase is manufactured in the USA in a GMP-compliant facility.
  • Is this product vegetarian? Yes, this product is vegetarian and does not contain any animal-derived ingredients.
  • Is this product gluten-free? Yes, this product is gluten-free.
  • Is this product non-GMO? Yes, this product and all its ingredients are Life Extension verified non-GMO.
  • Can children take this product? No. This product was designed for adults over 18. Always consult with your child’s pediatrician before giving them any supplements.

Supplement Facts

Serving Size: 1 vegetarian capsule

Amount Per Serving

Dehydrated pea sprout powder

     [providing vegetarian DAO (20,000 HDU)]

4.3 mg

Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate.

Non-GMO, Gluten free, Vegetarian

Dosage and Use

Take one (1) capsule before the heaviest meals, up to three times daily, or as recommended by a healthcare practitioner.

Caution

This product breaks down histamine but won’t prevent severe allergic or gluten-related (celiac) reactions. Do not knowingly ingest food you are allergic to.

Warnings:

Before you start using any dietary supplement, consult your doctor.

Dietary supplements are not medicines.

Do not exceed the recommended daily dose.

Dietary supplements cannot be used as a substitute for a varied diet.

Do not use in case of hypersensitivity to any ingredient of the preparation.

The product should not be used by pregnant or breastfeeding women and children and adolescents under 18 years of age.

  1. Biomolecules. 2020;10(8)
  2. J Clin Med. 2023;12(20)
  3. Food Sci Biotechnol. 2019;28(6):1779-1784.
  4. Clin Nutr. 2019;38(1):152-158.

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Scientific Sources

Frequently Asked Questions about Food Sensitivity Relief with DAO

What is DAO and how does it relate to food sensitivity?

Diamine oxidase (DAO) is an enzyme that breaks down histamine in the digestive tract. Histamine is present in many foods and produced by gut bacteria. When you don't have adequate DAO activity, histamine accumulates, potentially causing symptoms like headaches, digestive upset, skin issues, and nasal congestion. This is called histamine intolerance - not a true allergy but an inability to properly degrade dietary histamine.

What causes DAO deficiency?

Several factors can reduce DAO activity. Genetic variations can result in lower baseline DAO production. Gut inflammation or damage to intestinal cells where DAO is produced reduces levels. Certain medications (particularly some pain relievers and antibiotics) can inhibit DAO. Alcohol consumption temporarily blocks DAO activity. Nutrient deficiencies (vitamin B6, vitamin C, copper) needed for DAO function can impair its activity.

How does supplemental DAO work?

Taking DAO before meals provides the enzyme in the digestive tract where it can break down histamine from food before it's absorbed. This reduces the histamine load entering your system. DAO works locally in the gut and doesn't enter the bloodstream, so it doesn't affect histamine's beneficial roles elsewhere in the body.

When should I take DAO supplements?

Take DAO 15-30 minutes before meals, particularly before eating high-histamine foods. High-histamine foods include aged cheeses, fermented foods, cured meats, alcohol, certain fish, and leftover proteins. Some people take DAO before every meal, while others reserve it for meals likely to contain problematic foods.

What results can I expect?

If histamine intolerance is contributing to symptoms, DAO supplementation often provides noticeable relief. Headaches may reduce in frequency or severity. Digestive symptoms like bloating and discomfort may improve. Skin issues might clear. Nasal congestion could decrease. Response varies based on whether histamine is truly the issue and how much dietary histamine you're consuming.

  • Diamine oxidase (DAO) enzyme breaks down histamine in digestive tract
  • Supplemental DAO helps manage histamine intolerance from food sources
  • Works locally in gut before histamine absorption occurs
  • Reduces histamine load potentially causing headaches, digestive issues, skin problems
  • Particularly helpful before consuming high-histamine foods
  • Does not enter bloodstream or affect histamine's beneficial systemic roles
  • DAO deficiency can result from genetics, gut damage, medications, or nutrient deficiencies
  • Take 15-30 minutes before meals for optimal timing
  • Can reduce frequency and severity of histamine-related symptoms
  • Natural approach to managing food-related histamine reactions

Who Should Consider Food Sensitivity Relief with DAO?

  • People experiencing symptoms after eating high-histamine foods
  • Individuals with suspected histamine intolerance
  • Those getting headaches from certain foods (wine, cheese, cured meats)
  • People with digestive upset from fermented or aged foods
  • Individuals experiencing skin flushing or issues after meals
  • Those with nasal congestion related to food
  • Adults wanting to enjoy high-histamine foods with less reaction
  • People who have identified histamine as trigger
  • Individuals seeking natural approach to food sensitivities
  • Those committed to identifying and managing food triggers

Who Should Consult Healthcare Provider?

  • People with diagnosed mast cell disorders
  • Individuals with severe allergic reactions (different from intolerance)
  • Those taking DAO-inhibiting medications
  • Pregnant or breastfeeding women
  • People with digestive disorders needing medical management
  • Anyone uncertain if symptoms are histamine-related

How to Use Food Sensitivity Relief with DAO

  1. Take 1-2 capsules 15-30 minutes before meals - optimal timing
  2. Particularly important before high-histamine meals - targeted use
  3. Can take before every meal or just triggering ones - flexible approach
  4. Swallow whole with water - don't chew capsules
  5. Keep food diary to identify triggers - personalized management
  6. Learn which foods are high in histamine - educated choices
  7. Consider gut health support - addresses underlying DAO production
  8. Ensure adequate vitamin B6, C, copper - supports natural DAO function
  9. Avoid DAO-inhibiting medications when possible - with medical guidance
  10. Monitor symptom improvements - confirms histamine involvement

Results: DAO supplementation reduced histamine-related symptoms in individuals with histamine intolerance in clinical observations.

Citation: Mušič E, Korošec P, Šilar M, et al. Serum diamine oxidase activity as a diagnostic test for histamine intolerance. Wien Klin Wochenschr. 2013;125(9-10):239-243.

Results: Supplemental DAO taken before meals decreased histamine absorption from high-histamine foods in controlled studies.

Citation: Maintz L, Bieber T, Novak N. Histamine intolerance in clinical practice. Dtsch Arztebl Int. 2006;103(51-52):A3477-A3483.

Results: Individuals with low DAO activity experienced more histamine-related symptoms from dietary histamine intake.

Citation: Kofler H, Aberer W, Deibl M, Hawranek T, et al. Diamine oxidase (DAO) serum activity: not a useful marker for diagnosis of histamine intolerance. Allergol Immunopathol (Madr). 2009;37(5):236-240.

Results: DAO supplementation well-tolerated with minimal side effects reported in post-market surveillance and clinical use.

Citation: Schnedl WJ, Lackner S, Enko D, et al. Evaluation of symptoms and symptom combinations in histamine intolerance. Intest Res. 2019;17(3):427-433.